Results 281 to 290 of about 248,487 (359)

Sialylation as a checkpoint for inflammatory and complement-related retinal diseases. [PDF]

Front Cell Neurosci
Min Y, Cuevas-Rios G, Langmann T, Neumann H.   +3 more
europepmc   +1 more source

Exploring Phonon Interference: Insights From a Nano‐Scale Silicon Double Slit Atomistic Simulation

Advanced Theory and Simulations, EarlyView.
Classical Waves at the Atomic Scale: Molecular Dynamics Reveal Phonon Interference in Silicon Nanostructures. Abstract In this study, the classic double‐slit experiment, originally developed for light waves is successfully adapted, to investigate the behavior of phonons in crystalline silicon.
Efstratios Nikidis, Paul Desmarchelier, Yoshiaki Nakamura, Anne Tanguy, Konstantinos Termentzidis, Joseph Kioseoglou   +5 more
wiley   +1 more source

Exploring the intersection of atherosclerosis and Alzheimer's disease: the role of inflammation and complement activation. [PDF]

Inflamm Res
Vataja E, Ratti G, Safa A, Pagano M, Ferrante L, Meri S, Haapasalo K.   +6 more
europepmc   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Model-Informed Precision Dosing of Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria. [PDF]

Clin Pharmacokinet
Ter Avest M, Langemeijer SMC, van den Heuvel LPWJ, Baas LM, van de Kar NCAJ, Ter Heine R.   +5 more
europepmc   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Therapeutic strategies targeting complement in myasthenia gravis patients. [PDF]

J Neurol
Wang Y, Nao J, Duan Y, Li Z, Feng J.
europepmc   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem. [PDF]

Sci Rep
Bierer JD, Stanzel R, Henderson M, El-Rabahi T, Sapp J, Andreou P, Marshall JS, Conrad D, Horne D.   +8 more
europepmc   +1 more source

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

Advanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou   +15 more
wiley   +1 more source