Results 21 to 30 of about 277,934 (283)
Solvent reaction coordinate for an S$_N$2 reaction [PDF]
J. Chem. Phys. 153, 024103 (2020), 2020 We study the prototypical SN2 reaction Cl$^-$ + CH$_3$Cl $\to$ CH$_3$Cl + Cl$^-$ in water using quantum mechanics / molecular mechanics (QM/MM) computer simulations with transition path sampling and inertial likelihood maximization. We have identified a new solvent coordinate to complement the original atom-exchange coordinate used in the classic ...
arxiv +1 more source
Научно-практическая ревматология, 2000 A relationship between X - ray joints changes and functional activity of classical pathway complement components in R4 was investigated. 31 patients with the moderate activity ofRA (ARA 1987) have been examined. Disease duration was 4,5lyear±3,84 (SD). X-
D. L. Goryachev, T. V. Lebedeva
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Frontiers in Immunology, 2021 To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccinated ...
Lukas Muri +10 more
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Frontiers in Immunology, 2016 Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear.
Anne Rosbjerg +5 more
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Early complementopathy predicts the outcomes of patients with trauma
Trauma Surgery & Acute Care Open, 2019 Background Complementopathy (rapid complement activation and consumption after trauma) has been reported in trauma patients, but the underlying mechanism of these phenomena and their clinical significance remain unclear. This study aimed to determine the
Bin Liu +6 more
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Nucleation pathway of calcium sulfate hemihydrate (bassanite) from solution: implications for calcium sulfates on Mars [PDF]
J. Phys. Chem. C 2020, 2020 CaSO4 minerals (i.e. gypsum, anhydrite and bassanite) are widespread in natural and industrial environments. During the last several years, a number of studies have revealed that nucleation in the CaSO4-H2O system is non-classical, where the formation of crystalline phases involves several steps.
arxiv +1 more source
Frontiers in Immunology, 2022 Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host innate immune system, including the complement cascade. The Lyme disease spirochete, Borreliella burgdorferi, has evolved numerous outer membrane lipoproteins ...
Charles E. Booth +3 more
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Acta Pharmaceutica Sinica B, 2015 Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall ...
Mulu Wu +3 more
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The classical pathway triggers pathogenic complement activation in membranous nephropathy
Nature Communications, 2023 It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and ...
Larissa Seifert +23 more
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Frontiers in Immunology, 2018 The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz +6 more
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