Results 21 to 30 of about 387,249 (358)

The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes. [PDF]

PLoS ONE, 2009
Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
Veruska Cavalcanti Barros, Jéssica Góes Assumpção, André Miranda Cadete, Vânia Cristina Santos, Reginaldo Roris Cavalcante, Ricardo Nascimento Araújo, Marcos Horácio Pereira, Nelder Figueiredo Gontijo   +7 more
doaj   +5 more sources

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy. [PDF]

Acta Neuropathol Commun, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
McGonigal R, Cunningham ME, Yao D, Barrie JA, Sankaranarayanan S, Fewou SN, Furukawa K, Yednock TA, Willison HJ.   +8 more
europepmc   +4 more sources

Human pentraxin 3 binds to the complement regulator c4b-binding protein. [PDF]

PLoS ONE, 2011
The long pentraxin 3 (PTX3) is a soluble recognition molecule with multiple functions including innate immune defense against certain microbes and the clearance of apoptotic cells.
Anne Braunschweig, Mihály Józsi
doaj   +6 more sources

First-in-human study with SAR445088: A novel selective classical complement pathway inhibitor. [PDF]

Clin Transl Sci, 2023
Chow T, Shamszad P, Vinnard C, Yoon E, Belinski J, Karpenko I, Perrin L, Auwarter K, Storek M, Surks H, Wong N, Cohen YZ.   +11 more
europepmc   +3 more sources

Classical Complement Pathway Inhibition in a "Human-On-A-Chip" Model of Autoimmune Demyelinating Neuropathies. [PDF]

Adv Ther (Weinh), 2022
Rumsey JW, Lorance C, Jackson M, Sasserath T, McAleer CW, Long CJ, Goswami A, Russo MA, Raja SM, Gable KL, Emmett D, Hobson-Webb LD, Chopra M, Howard JF, Guptill JT, Storek MJ, Alonso-Alonso M, Atassi N, Panicker S, Parry G, Hammond T, Hickman JJ.   +21 more
europepmc   +3 more sources

A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway. [PDF]

Virulence, 2023
Bergmann R, Schroedl W, Müller U, Baums CG.   +3 more
europepmc   +3 more sources

Therapeutic Hypothermia Inhibits the Classical Complement Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy. [PDF]

Front Neurosci, 2021
Shah TA, Pallera HK, Kaszowski CL, Bass WT, Lattanzio FA.   +4 more
europepmc   +3 more sources

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

Frontiers in Immunology, 2020
The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies.
Nick S. Laursen, Dennis V. Pedersen, Heidi Gytz, Alessandra Zarantonello, Jens Magnus Bernth Jensen, Annette G. Hansen, Steffen Thiel, Gregers R. Andersen   +7 more
doaj   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

Transcriptional factor PU.1 regulates decidual C1q expression in early pregnancy in human [PDF]

, 2015
"Copyright: © 2015 Madhukaran, Kishore, Jamil, Teo, Choolani and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Choolani, M, Jamil, K, Kishore, U, Lu, J, Madhukaran, SP, Teo, BHD   +5 more
core   +7 more sources