Results 21 to 30 of about 265,122 (221)

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway. [PDF]

Eur J Immunol, 2014
Post‐translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory conditions through myeloperoxidase ...
Koro C, Bielecka E, Dahl-Knudsen A, Enghild JJ, Scavenius C, Brun JG, Binder V, Hellvard A, Bergum B, Jonsson R, Potempa J, Blom AM, Mydel P.   +12 more
europepmc   +2 more sources

Heme Interacts with C1q and Inhibits the Classical Complement Pathway [PDF]

Journal of Biological Chemistry, 2011
C1q is the recognition subunit of the first component of the classical complement pathway. It participates in clearance of immune complexes and apoptotic cells as well as in defense against pathogens. Inappropriate activation of the complement contributes to cellular and tissue damage in different pathologies, urging the need for the development of ...
Lubka T, Roumenina, Maria, Radanova, Boris P, Atanasov, Krastio T, Popov, Srinivas V, Kaveri, Sébastien, Lacroix-Desmazes, Véronique, Frémeaux-Bacchi, Jordan D, Dimitrov   +7 more
openaire   +3 more sources

Continual Low-Level Activation of the Classical Complement Pathway [PDF]

The Journal of Experimental Medicine, 2001
There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation. Analysis of freshly collected mouse and human plasma revealed that spontaneous C3 activation rapidly occurred with ...
Manderson, A, Pickering, Mark, Botto, Marina, Walport, Mark J, Parish, Christopher   +4 more
openaire   +5 more sources

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]

Nature Communications, 2016
C1q is known to initiate the activation of the complement classical pathway. Here, the authors show the C1q is expressed in the tumour microenvironment and can promote cancer cell migration and adhesion in a complement activation-independent manner.
Roberta Bulla, Claudio Tripodo, Damiano Rami, Guang Sheng Ling, Chiara Agostinis, Carla Guarnotta, Sonia Zorzet, Paolo Durigutto, Marina Botto, Francesco Tedesco   +9 more
doaj   +4 more sources

Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis. [PDF]

J Allergy Clin Immunol, 2017
Van Roey GA, Vanison CC, Wu J, Huang JH, Suh LA, Carter RG, Norton JE, Shintani-Smith S, Conley DB, Welch KC, Peters AT, Grammer LC, Harris KE, Hulse KE, Kato A, Stevens WW, Kern RC, Schleimer RP, Tan BK.   +18 more
europepmc   +2 more sources

Classical complement pathway activation in immune thrombocytopenia purpura: inhibition by a novel C1s inhibitor. [PDF]

Br J Haematol, 2016
Peerschke EI, Panicker S, Bussel J.
europepmc   +2 more sources

Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia. [PDF]

Hypertension, 2015
Penning M, Chua JS, van Kooten C, Zandbergen M, Buurma A, Schutte J, Bruijn JA, Khankin EV, Bloemenkamp K, Karumanchi SA, Baelde H.   +10 more
europepmc   +2 more sources

Activation of the classical complement pathway in myasthenia gravis with acetylcholine receptor antibodies

Muscle and Nerve, 2023
Myasthenia gravis (MG) is an autoimmune disease affecting the neuromuscular junction (NMJ) of skeletal muscle. Complement activation is one of the mechanisms by which anti–acetylcholine receptor (anti‐AChR) autoantibodies reduce synaptic transmission at ...
Y. Ozawa, A. Uzawa, Yosuke Onishi, M. Yasuda, Yuta Kojima, Satoshi Kuwabara   +5 more
semanticscholar   +1 more source

Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein

Frontiers in Immunology, 2021
The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Aleksandra Urban, Daria Kowalska, Grzegorz Stasiłojć, Alicja Kuźniewska, Anna Skrobińska, Emilia Arjona, Eugenia Castellote Alonso, María Ángeles Fenollosa Segarra, Ilse Jongerius, Ilse Jongerius, Robbert Spaapen, Simon Satchell, Marcel Thiel, Stanisław Ołdziej, Santiago Rodriguez de Córdoba, Marcin Okrój   +15 more
doaj   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source