Results 21 to 30 of about 61,585 (301)

Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential

Frontiers in Immunology, 2014
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp, Pamela H. Whitley, Kenji M. Cunnion, Kenji M. Cunnion, Neel Kumar Krishna, Neel Kumar Krishna   +5 more
doaj   +1 more source

Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis

Renal Failure, 2022
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima, Dan Inoue, Takeaki Wajima, Takahiro Uchida, Muneharu Yamada, Isao Ohsawa, Takashi Oda   +6 more
doaj   +1 more source

FUNCTIONAL ACTIVITY OF COMPLEMENT CLASSIC WAY ACTIVATION COMPONENTS AND ART1CULAS DAMAGE IN RHEUMATOID ARTRITIS

Научно-практическая ревматология, 2000
A relationship between X - ray joints changes and functional activity of classical pathway complement components in R4 was investigated. 31 patients with the moderate activity ofRA (ARA 1987) have been examined. Disease duration was 4,5lyear±3,84 (SD). X-
D. L. Goryachev, T. V. Lebedeva
doaj   +1 more source

Classical and alternative complement pathway activation by pneumococci [PDF]

Infection and Immunity, 1977
Sixty-two strains of Streptococcus pneumoniae were studied for their abilities to consume selected components of classical and alternative complement pathways in human sera. The classical pathway was blocked by chelating calcium with ethyleneglycol-bios (beta-aminoethyl ether)-N,N-tetraacetic acid and by removing C4. The alternative pathway was blocked
W P Reed, C G Stephens, Ralph C. Williams   +2 more
openaire   +2 more sources

Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals

Frontiers in Immunology, 2021
To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccinated ...
Lukas Muri, Lukas Muri, Emma Ispasanie, Emma Ispasanie, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke   +10 more
doaj   +1 more source

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus

Frontiers in Immunology, 2016
Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear.
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Mikkel-Ole Skjoedt, Gregory L Stahl, Peter Garred   +5 more
doaj   +1 more source

Early complementopathy predicts the outcomes of patients with trauma

Trauma Surgery & Acute Care Open, 2019
Background Complementopathy (rapid complement activation and consumption after trauma) has been reported in trauma patients, but the underlying mechanism of these phenomena and their clinical significance remain unclear. This study aimed to determine the
Bin Liu, Yansong Li, Qingwei Zhao, Alexander Dixon, Leopoldo Cancio, Michael Dubick, Jurandir Dalle Lucca   +6 more
doaj   +1 more source

Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (Cyprinus carpio)

Journal of Marine Science and Engineering, 2023
In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah, Akira Yamamoto, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao   +4 more
doaj   +1 more source

Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions

Frontiers in Immunology, 2022
Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host innate immune system, including the complement cascade. The Lyme disease spirochete, Borreliella burgdorferi, has evolved numerous outer membrane lipoproteins ...
Charles E. Booth, Alexandra D. Powell-Pierce, Jon T. Skare, Brandon L. Garcia   +3 more
doaj   +1 more source

Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides

Acta Pharmaceutica Sinica B, 2015
Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall ...
Mulu Wu, Hong Li, Yunyi Zhang, Daofeng Chen   +3 more
doaj   +1 more source