Results 301 to 310 of about 387,249 (358)

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

Current Understanding of the Pathogenesis of ANCA-Associated Vasculitis and Novel Treatment Options Targeting Complement Activation. [PDF]

Life (Basel)
Drouzas K, Kalogeropoulos P, Liapis G, Lionaki S.   +3 more
europepmc   +1 more source

Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During Pulmonary Hypertension

Advanced Science, EarlyView.
This study investigates the critical mechanisms underlying pulmonary hypertension progression, with a focus on the novel role of neutrophil‐derived S100A9 in endothelial dysfunction‐mediated pulmonary vascular remodeling. By integrating human lung samples, multi‐omics analyses, animal models, and mechanistic in vitro studies, it is revealed that how ...
Yu Guo, Zhengqiang Gao, Ruoyang Zhang, Huanyu Long, Muzhi Zhang, Lin Liu, Zhe An, Yuezhe Shi, Ye Cui, Yufeng Jia, Lei Wang, Ying Sun, Jie Liu, Wei Wang   +13 more
wiley   +1 more source

Inflammation-Driven Plaque Erosion in Atherosclerosis: A Focus on Complement System Pathways. [PDF]

Curr Atheroscler Rep
Ramoni D, Carbone F, Kraler S, Di Vece D, Montecucco F, Liberale L.   +5 more
europepmc   +1 more source

The complement system and kidney cancer: pathogenesis to clinical applications. [PDF]

J Clin Invest
Aalinkeel R, Quigg RJ, Alexander J.
europepmc   +1 more source

Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients. [PDF]

Front Immunol
Ferraz-Amaro I, Santos-Concepción S, Castro-Hernández J, Hernández-Hernández MV, Tejera Segura B, Luna C, Delgado-Frias E, Díaz-González F.   +7 more
europepmc   +1 more source

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation. [PDF]

Respir Res
Shivshankar P, Mueller-Ortiz SL, Domozhirov AY, Bi W, Collum SD, Doursout MF, Patel M, LeFebvre IN, Akkanti B, Yau S, Huang HJ, Hussain R, Karmouty-Quintana H.   +12 more
europepmc   +1 more source

Complement Factor B Deficiency Is Dispensable for Female Fertility but Affects Microbiome Diversity and Complement Activity. [PDF]

Int J Mol Sci
Sunamoto M, Morohoshi K, Sato B, Mihashi R, Inui M, Yamada M, Miyado K, Kawano N.   +7 more
europepmc   +1 more source

Complement biosynthesis in human brain: Insights from single-nucleus transcriptomics of hippocampus

Nguyen VD, Bright M, Zhou Y, Morgan BP, Zelek WM.   +4 more
europepmc   +1 more source

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Classical complement pathway factor alterations in narcolepsy

Acta Neuropsychiatrica, 2022
AbstractObjective:Narcolepsy is a chronic sleep disorder long hypothesised to be an autoimmune disease. Complement-mediated immune mechanisms have not been investigated in detail in narcolepsy. Our aim was to establish the significance of classical pathway activation in narcolepsy.Methods:Sera of 42 narcolepsy patients and 26 healthy controls were ...
Hande Yüceer, Duygu Gezen Ak, Gülçin Benbir Şenel, Erdinç Dursun, Vuslat Yılmaz, Derya Karadeniz, Erdem Tüzün, Cem İsmail Küçükali   +7 more
openaire   +2 more sources