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The non-classical functions of the classical complement pathway recognition subcomponent C1q
Immunology Letters, 2010C1q, the ligand recognition subcomponent of the classical complement pathway has steadily been gaining recognition as a bridge between innate and adaptive immunity. C1q has been shown to be involved in the modulation of various immune cells (such as dendritic cells, platelets, microglia cells and lymphocytes), clearance of apoptotic cells, a range of ...
Uday Kishore +3 more
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Classical pathway complement activity in Familial Mediterranean fever
Clinical Biochemistry, 2006The present study emphasizes the important role of the immune reactions in the pathogenesis of Familial Mediterranean fever. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3, and C4, were determined in the blood serum of 32 patients with FMF and 28 healthy subjects ...
A.A. Ayvazyan . +3 more
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Alternate and Classical Pathway Components of Complement in the Normal Cornea
Archives of Ophthalmology, 1980Activation of complement by either the classical or alternate pathway may be involved in corneal inflammation. This study was undertaken to determine whether the normal human cornea contains components for both classical and alternate pathway activation of complement.
Daniel B. Goldberg +4 more
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Monoclonal Antibodies against Components of the Classical Pathway of Complement
Complement and Inflammation, 1989Activation of the classical pathway of complement involves several binding and enzymatic cleavage processes. Binding and enzymatic activation results in the appearance of new structures in the individual components. This report describes the different activation steps for C1q, C1r, C1s, C4 and C2 and summarizes monoclonal antibodies reported so far ...
Michael Loos, Hans-Peter Heinz
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Activation of the Classic and Alternate Complement Pathways by Endotoxin
The Journal of Immunology, 1974Abstract The ability of bacterial endotoxin (LPS) to activate the complement system was studied in guinea pig serum (GPS). In serum chelated with ethyleneglycol tetraacetic acid (EGTA) 10 mM, which permits alternate complement pathway activation but inhibits classic complement pathway activation, lysis of LPS-coated sheep erythrocytes (E-
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Targeting Classical Complement Pathway to Treat Complement Mediated Autoimmune Diseases
2008Mice deficient for classical complement pathway (CCP) factor C4 are resistant to antibody and complement mediated experimental autoimmune myasthenia gravis (EAMG). Anti-C1q antibody administration before or following acetylcholine receptor immunization suppresses EAMG development by reducing lymph node cell IL-6 production and neuromuscular junction ...
Jing Li +4 more
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The classical and alternate pathways of complement in oral contraceptive users
Contraception, 1987Whole complement (CH50), C3, C4, the alternate pathway activity of complement (APH50) and factor B were measured in 159 women currently taking oral contraceptives and in 186 women who were not taking the pill. The mean levels of all components of the complement, except APH50, were found to be elevated in current users compared to non-users.
G. Lehner-Netsch +2 more
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Effects of anesthesia and operation on the classical pathway of complement activation
Clinical Immunology and Immunopathology, 1982Abstract The present study examined whether anesthesia and operation could alter serum complement function as reflected by CH 50 levels and individual component activity. Classical complement pathway function was significantly reduced, as reflected by lowered CH 50 levels, in patients undergoing anesthesia and operation.
Robert E. Lewis +2 more
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The Classical Complement Pathway: Activation and Regulation of the First Complement Component
1985Publisher Summary This chapter focuses on the activation and regulation of the first complement component. . The chapter outlines the history of the classical pathway of the complement system. Clq and C1 are bound and activated by immune complexes or aggregates containing IgG or IgM but not by those containing IgA, IgD, or IgE . Among IgG subclasses,
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Succinylated and acetylated concanavalin A activate the classical complement pathway
Biochemical and Biophysical Research Communications, 1981Abstract Succinylated and acetylated concanavalin A, but not the native lectin, lyse sheep erythrocytes in the presence of guinea pig complement. The effect appears to be specific since succinylated wheat germ agglutinin is inactive and hemolysis is inhibited selectively by α-D-methylglucopyranoside. Hemolytic activity is enhanced by preincubation of
John J. Langone, Regina Ejzemberg
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