Results 321 to 330 of about 248,487 (359)

Classical pathway complement activity in Familial Mediterranean fever

Clinical Biochemistry, 2006
The present study emphasizes the important role of the immune reactions in the pathogenesis of Familial Mediterranean fever. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3, and C4, were determined in the blood serum of 32 patients with FMF and 28 healthy subjects ...
A.A. Ayvazyan ., G.M. Mkrtchyan ., Anna Boyajyan, A.A. Beglaryan   +3 more
openaire   +3 more sources

Alternate and Classical Pathway Components of Complement in the Normal Cornea

Archives of Ophthalmology, 1980
Activation of complement by either the classical or alternate pathway may be involved in corneal inflammation. This study was undertaken to determine whether the normal human cornea contains components for both classical and alternate pathway activation of complement.
Daniel B. Goldberg, Bartly J. Mondino, Stuart I. Brown, David J. Schanzlin, Helen V. Ratajczak   +4 more
openaire   +3 more sources

Monoclonal Antibodies against Components of the Classical Pathway of Complement

Complement and Inflammation, 1989
Activation of the classical pathway of complement involves several binding and enzymatic cleavage processes. Binding and enzymatic activation results in the appearance of new structures in the individual components. This report describes the different activation steps for C1q, C1r, C1s, C4 and C2 and summarizes monoclonal antibodies reported so far ...
Michael Loos, Hans-Peter Heinz
openaire   +2 more sources

Activation of the Classic and Alternate Complement Pathways by Endotoxin

The Journal of Immunology, 1974
Abstract The ability of bacterial endotoxin (LPS) to activate the complement system was studied in guinea pig serum (GPS). In serum chelated with ethyleneglycol tetraacetic acid (EGTA) 10 mM, which permits alternate complement pathway activation but inhibits classic complement pathway activation, lysis of LPS-coated sheep erythrocytes (E-
openaire   +2 more sources

Evaluation of classical complement pathway activation in rheumatoid arthritis: measurement of C1q-C4 complexes as novel activation products.

Arthritis & Rheumatism, 2006
OBJECTIVE Novel activation products that are stable and minimally susceptible to in vitro artefacts have recently been described in the classical complement pathway.
D. Wouters, A. Voskuyl, Esmeralda T. H. Molenaar, B. Dijkmans, C. Hack   +4 more
semanticscholar   +1 more source

Targeting Classical Complement Pathway to Treat Complement Mediated Autoimmune Diseases

2008
Mice deficient for classical complement pathway (CCP) factor C4 are resistant to antibody and complement mediated experimental autoimmune myasthenia gravis (EAMG). Anti-C1q antibody administration before or following acetylcholine receptor immunization suppresses EAMG development by reducing lymph node cell IL-6 production and neuromuscular junction ...
Jing Li, Erdem Tüzün, Premkumar Christadoss, Shamsher S. Saini, Huan Yang   +4 more
openaire   +3 more sources

The classical and alternate pathways of complement in oral contraceptive users

Contraception, 1987
Whole complement (CH50), C3, C4, the alternate pathway activity of complement (APH50) and factor B were measured in 159 women currently taking oral contraceptives and in 186 women who were not taking the pill. The mean levels of all components of the complement, except APH50, were found to be elevated in current users compared to non-users.
G. Lehner-Netsch, J. Brisson, J.M. Delâge   +2 more
openaire   +3 more sources

Succinylated and acetylated concanavalin A activate the classical complement pathway

Biochemical and Biophysical Research Communications, 1981
Abstract Succinylated and acetylated concanavalin A, but not the native lectin, lyse sheep erythrocytes in the presence of guinea pig complement. The effect appears to be specific since succinylated wheat germ agglutinin is inactive and hemolysis is inhibited selectively by α-D-methylglucopyranoside. Hemolytic activity is enhanced by preincubation of
John J. Langone, Regina Ejzemberg
openaire   +3 more sources

Effects of anesthesia and operation on the classical pathway of complement activation

Clinical Immunology and Immunopathology, 1982
Abstract The present study examined whether anesthesia and operation could alter serum complement function as reflected by CH 50 levels and individual component activity. Classical complement pathway function was significantly reduced, as reflected by lowered CH 50 levels, in patients undergoing anesthesia and operation.
Robert E. Lewis, Julius M. Cruse, John V. Richey   +2 more
openaire   +3 more sources

Adiponectin binds C1q and activates the classical pathway of complement

Biochemical and Biophysical Research Communications, 2008
The adipose-specific protein adiponectin binds to a number of target molecules, including damaged endothelium and the surface of apoptotic cells. However, the significance of this binding remains unclear. This study demonstrates the binding of purified C1q to recombinant adiponectin under physiological conditions, and the dependence of this upon Ca(++)
Alexandra Walther, Philip W. Peake, John A. Charlesworth, Yvonne Shen   +3 more
openaire   +3 more sources