Results 51 to 60 of about 387,249 (358)

Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]

, 2012
Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core   +1 more source

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

Frontiers in Immunology, 2018
The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz, Rafael Bayarri-Olmos, Nikolaj Kirketerp-Møller, Sander van Putten, Katrine Pilely, Mikkel-Ole Skjoedt, Peter Garred   +6 more
doaj   +1 more source

Heme Interacts with C1q and Inhibits the Classical Complement Pathway [PDF]

Journal of Biological Chemistry, 2011
C1q is the recognition subunit of the first component of the classical complement pathway. It participates in clearance of immune complexes and apoptotic cells as well as in defense against pathogens. Inappropriate activation of the complement contributes to cellular and tissue damage in different pathologies, urging the need for the development of ...
Boris P. Atanasov, Véronique Frémeaux-Bacchi, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina, Krastio T. Popov, Maria Radanova, Sébastien Lacroix-Desmazes, Sébastien Lacroix-Desmazes, Sébastien Lacroix-Desmazes, Srini V. Kaveri, Srini V. Kaveri, Srini V. Kaveri   +15 more
openaire   +4 more sources

Complement-coagulation cross-talk: a potential mediator of the physiological activation of complement by low pH

Frontiers in Immunology, 2015
The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy, Ismet eBoral, Alan eBevington   +2 more
doaj   +1 more source

Different Complement Activation Pathways Underly Cognitive Impairment and Type 2 Diabetes Mellitus Combined With Cognitive Impairment

Frontiers in Aging Neuroscience, 2022
BackgroundThe immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the ...
Zhenxing Li, Weiwei Zhang, Feng Gao, Feng Gao, Qiqiang Tang, Dongmei Kang, Yong Shen, Yong Shen   +7 more
doaj   +1 more source

The Functional Amyloid Curli Protects Escherichia coli against Complement-Mediated Bactericidal Activity

Biomolecules, 2018
Escherichia coli strains may be beneficial or pathogenic. Many E. coli strains that cause human disease, especially those responsible for bacteremia and sepsis, express virulence factors that impart resistance to the complement system.
Steven G. Biesecker, Lauren K. Nicastro, R. Paul Wilson, Çağla Tükel   +3 more
doaj   +1 more source

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats. [PDF]

PLoS ONE, 2015
The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases. Consequently, therapeutic modulators of the classical, lectin and alternative pathways of the complement system are ...
Julia A Sharp, Pamela S Hair, Haree K Pallera, Parvathi S Kumar, Clifford T Mauriello, Julius O Nyalwidhe, Cody A Phelps, Dalnam Park, Nicole M Thielens, Stephen M Pascal, Waldon Chen, Diane M Duffy, Frank A Lattanzio, Kenji M Cunnion, Neel K Krishna   +14 more
doaj   +1 more source

Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D

Frontiers in Endocrinology, 2022
IntroductionWomen with polycystic ovary syndrome (PCOS) exhibit complement factor expression changes that may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, complement changes have been associated with vitamin D deficiency, a ...
Abu Saleh Md Moin, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin   +3 more
doaj   +1 more source

Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells [PDF]

, 2009
Intrarenal complement activation plays an important role in the progression of chronic kidney disease. A key target of the activated complement cascade is the proximal tubule, a site where abnormally filtered plasma proteins and complement factors ...
Abbate, Mauro, Buelli, Simona, Moioli, Daniela, Morigi, Marina, Noris, Marina, Pusey, Charles D., Remuzzi, Giuseppe, Zanchi, Cristina, Zipfel, Peter F., Zoja, Carla   +9 more
core   +1 more source

Pathways connecting two opposed bilayers with a fusion pore: A molecularly-informed phase field approach [PDF]

Soft Matter, 2020, 16, 366, 2019
A phase field model with two phase fields, representing the concentration and the head-tail separation of amphiphilic molecules, respectively, has been constructed using an extension of the Ohta-Kawasaki model (Macromolecules 19, 2621-2632 (1986)).
arxiv   +1 more source