Results 61 to 70 of about 141,643 (223)

Alterations in the complement cascade in post-traumatic stress disorder

Allergy, Asthma & Clinical Immunology, 2010
Background In the present study we assessed the functional state of the major mediator of the immune response, the complement system, in post-traumatic stress disorder (PTSD).
Hovhannisyan Lilit P, Mkrtchyan Gohar M, Sukiasian Samvel H, Boyajyan Anna S   +3 more
doaj   +1 more source

Classical pathway complement activation on human endothelial cells [PDF]

Molecular Immunology, 2007
Endothelial cells regulate vascular integrity and express complement binding proteins including gC1qR/p33 (gC1qR), which recognize C1q, a subunit of the first component of the classical complement pathway. Experiments were performed to investigate classical complement pathway activation on resting endothelial cells and endothelial cells exposed to ...
Ellinor I.B. Peerschke, Wei Yin, Babette B. Weksler, Berhane Ghebrehiwet   +3 more
openaire   +3 more sources

Blood platelets activate the classical pathway of human complement [PDF]

Journal of Thrombosis and Haemostasis, 2006
Activation of the complement system plays a key role in inflammation associated with vascular injury. Recently, platelet P-selectin was shown to activate C3 via the alternative pathway of human complement. As platelets also posses binding sites for C1q, the recognition unit of the classical complement pathway, the present study examined classical ...
Ellinor I.B. Peerschke, Berhane Ghebrehiwet, Wei Yin, S. E. Grigg   +3 more
openaire   +3 more sources

Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots

Frontiers in Immunology
The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang, Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Uday Kishore, Robert B. Sim   +7 more
doaj   +1 more source

Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes

PLoS Pathogens, 2019
The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r.
Jialei Xie, Hui Zhi, Ryan J. Garrigues, A. Keightley, B. Garcia, J. Skare   +5 more
semanticscholar   +1 more source

Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas

Frontiers in Immunology, 2019
C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent
Alessandro Mangogna, Chiara Agostinis, Deborah Bonazza, Beatrice Belmonte, Paola Zacchi, Gabriella Zito, Andrea Romano, Fabrizio Zanconati, Giuseppe Ricci, Giuseppe Ricci, Uday Kishore, Roberta Bulla   +11 more
doaj   +1 more source

Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor. [PDF]

PLoS ONE, 2012
Oversulfated chondroitin sulfate (OSCS) has become the subject of multidisciplinary investigation as a non-traditional contaminant in the heparin therapeutic preparations that were linked to severe adverse events.
Zhao-Hua Zhou, Mohsen Rajabi, Trina Chen, Elena Karnaukhova, Steven Kozlowski   +4 more
doaj   +1 more source

Hypoxic Processes Induce Complement Activation via Classical Pathway in Porcine Neuroretinas

Cells, 2021
Considering the fact that many retinal diseases are yet to be cured, the pathomechanisms of these multifactorial diseases need to be investigated in more detail.
Ana M. Mueller-Buehl, Torsten Buehner, Christiane Pfarrer, Leonie Deppe, Laura Peters, Burkhard H. Dick, Stephanie C. Joachim   +6 more
doaj   +1 more source

Inhibition of the Classical Pathway of Complement by Meningococcal Capsular Polysaccharides [PDF]

The Journal of Immunology, 2014
Abstract Almost all invasive Neisseria meningitidis isolates express capsular polysaccharide. Ab is required for complement-dependent killing of meningococci. Although alternative pathway evasion has received considerable attention, little is known about classical pathway (CP) inhibition by meningococci, which forms the basis of this ...
Rosane B. DeOliveira, Sarika Agarwal, Shreekant Vasudhev, Sanjay Ram   +3 more
openaire   +2 more sources

C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration

International Journal of Retina and Vitreous, 2022
Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal neurodegenerative disorder. Human genetic data support the complement system as a key component of pathogenesis in AMD, which has been further supported by pre ...
Ted Yednock, Donald S. Fong, Eleonora M. Lad   +2 more
doaj   +1 more source