Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]
, 2019 The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto +5 more
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DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER
Медицинская иммунология, 2014 . During attacks of familial mediterranean fever (FMF), multiple systemic events are triggered, most of which promote autoinflammatory reactions. A molecular pattern of immune abnormalities in FMF is yet unclear.
G. M. Mkrtchyan +4 more
doaj +1 more source
Bio-Protocol, 2021 The complement system is a central component of innate immunity, responsible for recognition and killing of bacteria by tagging invaders through opsonisation, thereby promoting phagocytosis, and by direct lysis.
Wioleta Zelek
doaj +1 more source
Alterations in the complement cascade in post-traumatic stress disorder
Allergy, Asthma & Clinical Immunology, 2010 Background In the present study we assessed the functional state of the major mediator of the immune response, the complement system, in post-traumatic stress disorder (PTSD).
Hovhannisyan Lilit P +3 more
doaj +1 more source
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]
, 2012 Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core +1 more source
Hypoxic Processes Induce Complement Activation via Classical Pathway in Porcine Neuroretinas
Cells, 2021 Considering the fact that many retinal diseases are yet to be cured, the pathomechanisms of these multifactorial diseases need to be investigated in more detail.
Ana M. Mueller-Buehl +6 more
doaj +1 more source
Journal of Experimental Medicine, 1992 Serum mannose-binding protein (MBP) is a C-type lectin that binds to terminal mannose and N-acetylglucosamine moieties present on surfaces of certain pathogens and activates the classical complement pathway.
M. Matsushita, Teizo Fujita
semanticscholar +1 more source
Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]
, 2007 The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Botto, M. +3 more
core
Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model. [PDF]
, 2013 BackgroundThe aneurysm clip impact-compression model of spinal cord injury (SCI) is a standard injury model in animals that closely mimics the primary mechanism of most human injuries: acute impact and persisting compression.
Boutros, Paul C +5 more
core +3 more sources
Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region [PDF]
, 2017 The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases.
De Pablos, Luis Miguel +5 more
core +3 more sources