Results 81 to 90 of about 265,122 (221)

Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots

Frontiers in Immunology
The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang, Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Uday Kishore, Robert B. Sim   +7 more
doaj   +1 more source

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis. [PDF]

, 2016
Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown.
Genster, Ninette, Gál, Péter, Pilely, Katrine, Pál, Gábor, Rosbjerg, Anne   +4 more
core   +1 more source

Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas

Frontiers in Immunology, 2019
C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent
Alessandro Mangogna, Chiara Agostinis, Deborah Bonazza, Beatrice Belmonte, Paola Zacchi, Gabriella Zito, Andrea Romano, Fabrizio Zanconati, Giuseppe Ricci, Giuseppe Ricci, Uday Kishore, Roberta Bulla   +11 more
doaj   +1 more source

Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes

PLoS Pathogens, 2019
The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r.
Jialei Xie, Hui Zhi, Ryan J. Garrigues, A. Keightley, B. Garcia, J. Skare   +5 more
semanticscholar   +1 more source

Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor. [PDF]

PLoS ONE, 2012
Oversulfated chondroitin sulfate (OSCS) has become the subject of multidisciplinary investigation as a non-traditional contaminant in the heparin therapeutic preparations that were linked to severe adverse events.
Zhao-Hua Zhou, Mohsen Rajabi, Trina Chen, Elena Karnaukhova, Steven Kozlowski   +4 more
doaj   +1 more source

Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor Links Complement and Hemostasis-Thrombosis [PDF]

, 2013
Background: Vascular endothelial cells (ECs) express and release protein components of the complement pathways, as well as secreting and anchoring ultra-large von Willebrand factor (ULVWF) multimers in long string-like structures that initiate platelet ...
Moake, Joel, Turner, Nancy A.
core   +2 more sources

C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration

International Journal of Retina and Vitreous, 2022
Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal neurodegenerative disorder. Human genetic data support the complement system as a key component of pathogenesis in AMD, which has been further supported by pre ...
Ted Yednock, Donald S. Fong, Eleonora M. Lad   +2 more
doaj   +1 more source

MINI-REVIEW: SYSTEMIC LUPUS ERYTHEMATOSUS AND DEFICIENCIES OF EARLY COMPONENTS OF THE COMPLEMENT CLASSICAL PATHWAY

Frontiers in Immunology, 2016
The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
Lourdes eIsaac, Ana Catarina Lunz Macedo
doaj   +1 more source

Electrostatic Steering Accelerates C3d:CR2 Association. [PDF]

, 2016
Electrostatic effects are ubiquitous in protein interactions and are found to be pervasive in the complement system as well. The interaction between complement fragment C3d and complement receptor 2 (CR2) has evolved to become a link between innate and ...
Dimitrios Morikis, Gary A. Huber, Holers V. M., Rohith R. Mohan, Zipfel P. F.   +4 more
core   +2 more sources

Covalent association of C3b with C4b within C5 convertase of the classical complement pathway

Journal of Experimental Medicine, 1987
The C5 convertase of the classical complement pathway is a complex enzyme consisting of three complement fragments, C4b, C2a, and C3b. Previous studies have elucidated functional roles of each subunit (4, 6, 7), but little is known about how the subunits
Yuko Takata, Taroh Kinoshita, H. Kozono, J. Takeda, Etsuko Tanaka, Kyongsu Hong, Kozo Inoue   +6 more
semanticscholar   +1 more source