Results 51 to 60 of about 39,695 (239)
Learning to like disgust: Neuronal correlates of counterconditioning
Frontiers in Human Neuroscience, 2013 Converging lines of research suggest that exaggerated disgust responses play a crucial role in the development and maintenance of certain anxiety disorders. One strategy that might effectively alter disgust responses is counterconditioning. In this study,
Jan eSchweckendiek +8 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The Role of Behaviourist Theory in Educational Technology [PDF]
دراسات تربوية و نفسية - مجلة كلية التربية بالزقازيقEducators from behaviourist theory’s perspective can shape the behaviour and responses of learners to a specific stimulus in order to help them acquire new knowledge.. Research has been performed, previously, into how students learn and gain information,
doaj +1 more source
Mismatch Negativity in Rat Auditory Cortex Represents the Empirical Salience of Sounds
Frontiers in Neuroscience, 2018 Mismatch negativity (MMN) is an N-methyl-D-aspartic acid-mediated component and thus has been widely considered a major candidate biomarker of schizophrenia.
Tomoyo Isoguchi Shiramatsu +1 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Cortico-Hippocampal Computational Modeling Using Quantum-Inspired Neural Networks
Frontiers in Computational Neuroscience, 2020 Many current computational models that aim to simulate cortical and hippocampal modules of the brain depend on artificial neural networks. However, such classical or even deep neural networks are very slow, sometimes taking thousands of trials to obtain ...
Mustafa Khalid +9 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
An Amygdala-Inspired Classical Conditioning Model Implemented on an FPGA for Home Service Robots
IEEE Access, 2020 This study develops an intelligent system for home service robots mimicking human brain function that can manage common knowledge applicable to any environment and local knowledge reflecting its specific environment.
Yuichiro Tanaka +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source