Results 71 to 80 of about 45,164 (282)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Brain Sciences, 2012 The latency of startle reflex potentiation may shed light on the aware and unaware processes underlying associative learning, especially associative fear learning.
Ole Åsli, Magne A. Flaten
doaj +1 more source
Cortico-Hippocampal Computational Modeling Using Quantum-Inspired Neural Networks
Frontiers in Computational Neuroscience, 2020 Many current computational models that aim to simulate cortical and hippocampal modules of the brain depend on artificial neural networks. However, such classical or even deep neural networks are very slow, sometimes taking thousands of trials to obtain ...
Mustafa Khalid +9 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The influence of classical-conditioning procedures on subsequent attention to the conditioned brand. [PDF]
Three experiments are used to investigate the influence of conditioning procedures on attention to a conditioned stimulus. In experiment 1, scenes presented in a sequence that is consistent with prescribed conditioning procedures are shown to encourage ...
Janiszewski, C, Warlop, Luk
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An Amygdala-Inspired Classical Conditioning Model Implemented on an FPGA for Home Service Robots
IEEE Access, 2020 This study develops an intelligent system for home service robots mimicking human brain function that can manage common knowledge applicable to any environment and local knowledge reflecting its specific environment.
Yuichiro Tanaka +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Interstimulus Interval in Classical Pupillary Conditioning
, 1968 Classical pupillary conditioning to CS-UCS intervals of 1.5, 6, and 9 sec. was studied in adult human beings. There was no evidence of uniform conditioning in any experimental group. Nevertheless, one or more Ss did condition in each experimental group.
Hiram E. Fitzgerald, Yvonne Brackbill
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
, 1999 Previous functional neuroimaging studies have characterized brain systems mediating associative learning using classical delay conditioning paradigms.
Buchel, C +7 more
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