Results 61 to 70 of about 1,462,604 (241)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging [PDF]

, 1999
Previous functional neuroimaging studies have characterized brain systems mediating associative learning using classical delay conditioning paradigms.
Buchel, C, Friston, K., Armony, J., Armony, J, Dolan, R, Dolan, R. ; https://orcid.org/, Buchel, C., Friston, K   +7 more
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Olfactory classical PER conditioning protocol.

, 2022
Experimental procedure of paired group olfactory classical PER conditioning (inspired by Matsumoto et al. 2012). Lavender (conditioning stimulus, CS) was applied for 5s. After 3s, sucrose 50% (unconditioning stimulus, US) was presented. Each bee received
Jacques Lebreton (602836), Monique Mathé-Allainmat (2484094), Xavier Pineau (13194737), Emiliane Taillebois (560079), Alison Cartereau (8803901), Steeve H. Thany (7272482)   +5 more
core   +1 more source

Classical Fear Conditioning in Turtles (Chrysemys picta)

International Journal of Comparative Psychology
In all organisms, fear conditioning is a behavior that would be expected to be adaptive for anticipating dangerous stimuli.  It therefore should have been selected for in the course of evolution.
Christopher Lau, Cassidy Hu, Justin Koprowski, Zachary Lee, Aayush Narula, Sanjana Sankaran, Juliana Welk, Alice S. Powers   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Learning to like disgust: Neuronal correlates of counterconditioning

Frontiers in Human Neuroscience, 2013
Converging lines of research suggest that exaggerated disgust responses play a crucial role in the development and maintenance of certain anxiety disorders. One strategy that might effectively alter disgust responses is counterconditioning. In this study,
Jan eSchweckendiek, Tim eKlucken, Christian Josef Merz, Christian Josef Merz, Sabine eKagerer, Bertram eWalter, Dieter eVaitl, Rudolf eStark, Rudolf eStark   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source