Results 61 to 70 of about 247,743 (267)

Selective inference after feature selection via multiscale bootstrap

open access: yes, 2021
It is common to show the confidence intervals or $p$-values of selected features, or predictor variables in regression, but they often involve selection bias. The selective inference approach solves this bias by conditioning on the selection event.
Shimodaira, Hidetoshi, Terada, Yoshikazu
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Visual Learning In The Perception Of Texture: Simple And Contingent Aftereffects Of Texture Density [PDF]

open access: yes, 1996
Novel results elucidating the magnitude, binocularity and retinotopicity of aftereffects of visual texture density adaptation are reported as is a new contingent aftereffect of texture density which suggests that the perception of visual texture density ...
Durgin, Frank H., Proffitt, D. R.
core   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Lower and Upper Conditioning in Quantum Bayesian Theory [PDF]

open access: yes, 2018
Updating a probability distribution in the light of new evidence is a very basic operation in Bayesian probability theory. It is also known as state revision or simply as conditioning.
Jacobs, Bart
core   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Obstacle Avoidance by Means of an Operant Conditioning Model [PDF]

open access: yes, 1995
This paper describes the application of a model of operant conditioning to the problem of obstacle avoidance with a wheeled mobile robot. The main characteristic of the applied model is that the robot learns to avoid obstacles through a learning-by-doing
Coronado, Juan López   +2 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Associative memory stored by functional novel pathway rather than modifications of preexisting neuronal pathways [PDF]

open access: yes, 2006
Associative conditioning involves changes in the processing pathways activated by sensory information to link the conditioned stimulus (CS) to the conditioned behavior.
Benjamin, Paul R   +3 more
core   +1 more source

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