Results 71 to 80 of about 247,743 (267)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Learning to like disgust: Neuronal correlates of counterconditioning
Frontiers in Human Neuroscience, 2013 Converging lines of research suggest that exaggerated disgust responses play a crucial role in the development and maintenance of certain anxiety disorders. One strategy that might effectively alter disgust responses is counterconditioning. In this study,
Jan eSchweckendiek +8 more
doaj +1 more source
The Mere Exposure Effect and Classical Conditioning [PDF]
, 2015 This study investigated Zajonc’s hypothesized link between the mere exposure effect and classical conditioning. In the first part of the experiment, participants were presented a photograph of a person.
Wong, Rosalyn
core +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Cortico-Hippocampal Computational Modeling Using Quantum-Inspired Neural Networks
Frontiers in Computational Neuroscience, 2020 Many current computational models that aim to simulate cortical and hippocampal modules of the brain depend on artificial neural networks. However, such classical or even deep neural networks are very slow, sometimes taking thousands of trials to obtain ...
Mustafa Khalid +9 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mismatch Negativity in Rat Auditory Cortex Represents the Empirical Salience of Sounds
Frontiers in Neuroscience, 2018 Mismatch negativity (MMN) is an N-methyl-D-aspartic acid-mediated component and thus has been widely considered a major candidate biomarker of schizophrenia.
Tomoyo Isoguchi Shiramatsu +1 more
doaj +1 more source
An Amygdala-Inspired Classical Conditioning Model Implemented on an FPGA for Home Service Robots
IEEE Access, 2020 This study develops an intelligent system for home service robots mimicking human brain function that can manage common knowledge applicable to any environment and local knowledge reflecting its specific environment.
Yuichiro Tanaka +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Brain Sciences, 2012 The latency of startle reflex potentiation may shed light on the aware and unaware processes underlying associative learning, especially associative fear learning.
Ole Åsli, Magne A. Flaten
doaj +1 more source