Epigenetic aging of classical monocytes from healthy individuals [PDF]
, 2020 ABSTRACTThe impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterations, as well as the corresponding proteomic and metabolomic data for plasma, using healthy ...
Shchukina, Irina +27 more
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Monocyte subsets, stanford-A acute aortic dissection, and carotid srtery stenosis. new evidences [PDF]
, 2019 Monocytes are a heterogeneous cell population distinguished into three subsets with distinctive phenotypic and functional properties: "classical" (CD14++CD16-), "intermediate" (CD14++CD16+), and "nonclassical" (CD14+CD16++).
Cifani, Noemi +4 more
core +1 more source
Aging impairs mitochondrial respiratory capacity in classical monocytes
Experimental Gerontology, 2018 Aging is a critical healthcare concern, with age-related inflammation disposing individuals to a variety of diseases. Monocytes are affected by the aging process, with increased inflammation and impaired cellular functions such as phagocytosis. Mechanisms by which aging alters monocyte function are unknown, but recent research suggests that the balance
Brandt D, Pence, Johnathan R, Yarbro
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The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]
, 2015 The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R +32 more
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Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain. [PDF]
, 2018 Traumatic brain injury (TBI) is a leading cause for neurological disabilities world-wide. TBI occurs most frequently among the elderly population, and elderly TBI survivors suffer from reduced recovery and poorer quality of life. The effect of age on the
Chou, Austin +4 more
core +6 more sources
Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]
, 2010 Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M. +8 more
core +1 more source
Expression of CD163 and HLA-DR molecules on the monocytes in chronic lymphocytic leukemia patients
Folia Histochemica et Cytobiologica, 2020 INTRODUCTION: Human peripheral blood monocytes are the part of the leukemia microenvironment. We examined three monocyte subgroups: classical (CD14++CD16–), intermediate (CD14++CD16+) and non-classical (CD14+CD16++) monocytes. As these subpopulations can
Wioleta Kowalska
doaj +1 more source
Non-classical monocytes as mediators of tissue destruction in arthritis [PDF]
Annals of the Rheumatic Diseases, 2018 Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage. The role of the two monocyte subsets, classical monocytes (expressing CD115, Ly6C and CCR2) and non-classical monocytes (which are CD115 positive, but low in Ly6C and CCR2), in serving as precursors for OC in ...
Puchner +23 more
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An updated portrait of monocyte-macrophages in classical Hodgkin lymphoma
Frontiers in Oncology, 2023 Classical Hodgkin lymphoma (cHL) is a unique neoplastic ecosystem characterized by a heterogeneous immune infiltrate surrounding the rare malignant Hodgkin Reed-Sternberg cells. Though less abundant than T-cells, tumor-infiltrating macrophages play a pivotal role in supporting HRS survival through cell-to-cell and paracrine interactions.
Ferrarini, Isacco +5 more
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Colony stimulating factor-1 receptor as a treatment for cognitive deficits postfractionated whole-brain irradiation. [PDF]
, 2017 Whole-brain irradiation (WBI) is commonly used to treat primary tumors of the central nervous systems tumors as well as brain metastases. While this technique has increased survival among brain tumor patients, the side effects of including a decline in ...
Rosi, Susanna
core +2 more sources