Results 31 to 40 of about 1,360,367 (244)

Relationships between serum HMGB1 concentration and subpopulation composition of circulating monocytes in patients with subclinical atherosclerosis

Медицинская иммунология, 2022
Chronic non-infectious inflammation of low intensity is the most important mechanism of development and progression in atherosclerosis. Under the conditions of persistent non-resolving inflammation observed in the vascular wall and atherosclerotic plaque
V. V. Genkel, I. I. Dolgushin, I. L. Baturina, A. Yu. Savochkina, K. V. Nikushkina, A. A. Minasova, L. R. Pykhova, A. S. Kuznetcova, I. I. Shaposhnik   +8 more
doaj   +1 more source

Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis

Scientific Reports, 2021
Spondyloarthritis (SpA) is characterized by chronic inflammation and structural damage involving spine and peripheral joints. Monocytes, as part of innate immune system, following migration into affected tissue, may play a role in the pathogenesis of SpA.
Małgorzata Stec, Michał Seweryn, Mariusz Korkosz, Zofia Guła, Rafał Szatanek, Kazimierz Węglarczyk, Magdalena Rutkowska-Zapała, Marzena Lenart, Marcin Czepiel, Jarosław Czyż, Jarosław Baran, Anna Gruca, Kamila Wojnar-Lasoń, Paweł Wołkow, Maciej Siedlar   +14 more
doaj   +1 more source

Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic infammation [PDF]

, 2020
Perinatal hepatic inflammation can have devastating consequences. Monocytes play an important role in the initiation and resolution of inflammation, and their diverse functions can be attributed to specific cellular subsets: pro-inflammatory or classical
Maher, Jacquelyn J., Polovina, Katya, Rosenberg, Katherine A., Levy, Claire S, Levy, Claire S., Mattis, Aras N., Wang, Bruce M, Nijagal, Amar, Mattis, Aras N, Van Dyken, Steven, Rosenberg, Katherine A, Tsui, Margaret, Wang, Bruce M., Maher, Jacquelyn J, Mack, Matthias, Alkhani, Anas   +15 more
core   +1 more source

Subgroups of monocytes predict cardiovascular events in patients with coronary heart disease. The PHAMOS trial (Prospective Halle Monocytes Study)What this paper addsWhat is known about this topic

Hellenic Journal of Cardiology, 2019
Background: Monocytes can be differentiated by the presence of CD14 and CD16 (CD14++CD16-, classical; CD14++CD16+, intermediate and CD14 + CD16++, non-classical monocytes). Recent studies have reported conflicting results regarding an association between
Florian Höpfner, Marrit Jacob, Christof Ulrich, Martin Russ, Andreas Simm, Rolf E. Silber, Matthias Girndt, Michel Noutsias, Karl Werdan, Axel Schlitt   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Non-classical monocytes as mediators of tissue destruction in arthritis [PDF]

, 2018
OBJECTIVES: Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage.
Mikami, Y., Puchner, A., Hofmann, M., Koenders, M.I., Hayer, S., Redlich, K., Bonelli, M., Niederreiter, B., Brunner, J.S., Fischer, A., Leiss, H., O'Shea, J.J., Binder, N.B., Karonitsch, T., Saferding, V., Simader, E., Bluml, S., Goncalves-Alves, E., Steiner, C.W., Podesser, B.K., Smolen, J.S., Menche, J., Caldera, M.   +22 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Association of intermediate monocytes with dengue severity among the pediatric population of Odisha, India

Scientific Reports
Dengue virus (DENV) infection in children exhibits varied clinical presentations, wherein the role of monocytes is important in the innate immune response. In this study, laboratory-confirmed DENV pediatric patients (n = 120), with DENV-2 infection, were
Manoj Kumar Dash, Sagnika Samal, Shailesh Rout, Rajesh Kumar Bhola, Janeka Gartia, Ishani Saha, Chinmay Kumar Behera, Hamida Hamdi, Mahesh Chandra Sahu, Biswadeep Das   +9 more
doaj   +1 more source

Revising CX3CR1 Expression on Murine Classical and Non-classical Monocytes

Frontiers in Immunology, 2020
In mice, monocytes (Mo) are conventionally described as CX3CR1low classical Mo (CMo) and CX3CR1high non-classical Mo (NCMo) based on the expression of EGFP in Cx3cr1+/EGFP mice and by analogy with human CX3CR1 expression.
Aïda Meghraoui-Kheddar, Aïda Meghraoui-Kheddar, Sandrine Barthelemy, Alexandre Boissonnas, Christophe Combadière   +4 more
doaj   +1 more source