Helminth species specific expansion and increased TNF-alpha production of non-classical monocytes during active tuberculosis [PDF]
PLoS Neglected Tropical Diseases, 2021 Both Mycobacterium tuberculosis infection and helminths may affect innate immune mechanisms such as differential effects on monocytes towards the non-classical and intermediate subsets that favor bacterial persistence.
Gezahegn Bewket +5 more
semanticscholar +2 more sources
Regulation of peripheral classical and non-classical monocytes on infliximab treatment in patients with rheumatoid arthritis and ankylosing spondylitis [PDF]
RMD Open, 2016 Objective To investigate the regulatory effect of tumour necrosis factor (TNF) blockade with infliximab on the distribution of peripheral blood monocyte subpopulations in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Methods
Aeberli D +5 more
openaire +6 more sources
Blood monocytes and their subsets: established features and open questions
Frontiers in Immunology, 2015 In contrast to the past reliance on morphology the identification and enumeration of blood monocytes is nowadays done with monoclonal antibodies and flow cytometry and this allows for subdivision into classical, intermediate and non-classical monocytes ...
Loems eZiegler-Heitbrock
doaj +3 more sources
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation [PDF]
Scientific Reports, 2020 Perinatal hepatic inflammation can have devastating consequences. Monocytes play an important role in the initiation and resolution of inflammation, and their diverse functions can be attributed to specific cellular subsets: pro-inflammatory or classical
A. Alkhani +10 more
semanticscholar +3 more sources
Epigenetics in non-classical monocytes support their pro-inflammatory gene expression [PDF]
Immunobiology, 2020 Non-classical human monocytes are characterized by high-level expression of cytokines like TNF, but the mechanisms involved are elusive. We have identified miRNAs and CpG-methylation sites that are unique to non-classical monocytes, defined via CD14 and CD16 expression levels. For down-regulated miRNAs that are linked to up-regulated mRNAs the dominant
Zhang, L. +8 more
openaire +5 more sources
In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets [PDF]
Proteomes, 2018 Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression of some surface antigens, mainly ...
Víctor Segura +18 more
doaj +8 more sources
Am J Physiol Cell PhysiolMast-Cell Expressed Membrane Protein-1 (MCEMP1) is higher in Idiopathic Pulmonary Fibrosis (IPF) patients with increased risk of death. Here we aimed to establish the mechanistic role of MCEMP1 in pulmonary fibrosis.
Perrot CY +11 more
europepmc +2 more sources
Immune complex-induced haptokinesis in human non-classical monocytes. [PDF]
Front Immunol, 2023 Formation and deposition of immune complexes (ICs) are hallmarks of various autoimmune diseases. Detection of ICs by IC receptors on leukocytes induces downstream signaling and shapes the local immune response. In many cases the pathological relevance of ICs is not well understood.
Preuß SL +7 more
europepmc +5 more sources
Decreased classical monocytes and CD163 expression in TB patients: an indicator of drug resistance
Brazilian Journal of Microbiology, 2021 Shāh Jahan +2 more
exaly +2 more sources
Diminished Non-Classical Monocytes in the Blood Associate with Disease Severity in Alcoholic Hepatitis. [PDF]
Clin Exp Gastroenterol, 2021 Elisabeth Busk Rasmussen,1 Lotte Lindgreen Eriksen,2 Stinne Ravn Greisen,1 Anne Louise Hansen,1 Mikkel Carstensen,1 Thomas Damgaard Sandahl,2 Sidsel Støy,2 Tue Wenzel Kragstrup1,3 1Department of Biomedicine, Aarhus University, Aarhus, Denmark ...
Rasmussen EB +7 more
europepmc +2 more sources