Results 41 to 50 of about 1,360,367 (244)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes [PDF]

, 2012
Copyright @ 2012, American Society for Microbiology.Human coronaviruses are associated with upper respiratory tract infections that occasionally spread to the lungs and other organs.
Lorin, V, Tangy, Frédéric, Vabret, Astrid, Vidalain, Pierre-Olivier, Tangy, F, Escriou, Nicolas, Millet, J, Escriou, N, Law, H, Albert, ML, Millet, Jean, K., Nal, B, Law, Helen, Albert, Matthew L, Vabret, A, Nal, Béatrice, Lorin, Valérie, Vidalain, PO, Mesel-Lemoine, Mariana   +18 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Additional analyses of monocytes reveals diversity of surface expression on classical, intermediate, and non-classical monocytes.

, 2015
A. Examples of monocyte gating from a healthy volunteer control and DLBCL patient. Mononuclear cells were gated from CD45+ WBCs ([WBCs]). CD14+ monocytes were gated from [MNCs].
Allan B. Dietz (709538), Patrick B. Johnston (418028), Virginia P. Van Keulen (373212), Dennis A. Gastineau (709537), Mary L. Maas (709536), Tobias Peikert (544208), Michael P. Gustafson (49708), Yi Lin (49406)   +7 more
core   +1 more source

Frequency of intermediate and non-classical monocytes to the total monocytes by HIV (H) and CVD(C) status.

, 2023
Frequency of intermediate and non-classical monocytes to the total monocytes by HIV (H) and CVD(C) status.
Karin Mueller (579839), Joan W. Berman (10860768), Klaus Ley (8593), Mardge H. Cohen (7923182), Igho Ofotokun (4059922), Stephen Gange (15674986), Tao Wang (12008), Kathryn Anastos (119435), Alan L. Landay (7919387), Phyllis C. Tien (7923128), Jason M. Lazar (10002157), Howard N. Hodis (9338345), David B. Hanna (10649576), Yanal Ghosheh (3404441), Sonya L. Heath (11605483), Qibin Qi (172143), Erik Ehinger (13558375), Juan Lin (171491), Russell P. Tracy (7300421), Wendy J. Mack (7923125), Chenglong Liu (317596), Robert C. Kaplan (7699334)   +21 more
core   +1 more source

Monocyte Phenotypes and Physical Activity in Patients with Carotid Atherosclerosis

Antioxidants, 2022
Atherosclerosis is associated with low-grade inflammation involving circulating monocytes. It has been shown that the levels of intermediate pro-inflammatory monocytes are associated with cardiovascular mortality and risk of ischemic stroke.
Mathilde Mura, Michèle Weiss-Gayet, Nellie Della-Schiava, Erica Chirico, Patrick Lermusiaux, Marie Chambion-Diaz, Camille Faes, Anaelle Boreau, Bénédicte Chazaud, Antoine Millon, Vincent Pialoux   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum

, 2010
Acute exercise alters the surface expression of toll-like receptors (TLRs) and HLA.DR on blood monocytes, which could transiently compromise immunity.
O’Connor, Daniel P., Florida-James, Geraint, Booth, Stephen, Spielmann, Guillaume, Simpson, Richard J., O'Connor, Daniel P, McFarlin, Brian K., Florida-James, Geraint D., McFarlin, Brian K, Simpson, Richard J   +9 more
core   +1 more source

The Association of Lipoprotein(a) and Circulating Monocyte Subsets with Severe Coronary Atherosclerosis

Journal of Cardiovascular Development and Disease, 2021
Background and aims: Chronic inflammation associated with the uncontrolled activation of innate and acquired immunity plays a fundamental role in all stages of atherogenesis.
Olga I. Afanasieva, Anastasya Yu. Filatova, Tatiana I. Arefieva, Elena A. Klesareva, Alexandra V. Tyurina, Natalia V. Radyukhina, Marat V. Ezhov, Sergei N. Pokrovsky   +7 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source