6-Sulfo LacNAc (Slan) as a Marker for Non-classical Monocytes [PDF]
Frontiers in Immunology, 2019 Monocytes are subdivided into three subsets, which have different phenotypic and functional characteristics and different roles in inflammation and malignancy.
Thomas P. Hofer +4 more
doaj +10 more sources
Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine. [PDF]
Front Immunol, 2022 Introduction Macrophages play an important role in intestinal wound healing. However, the trajectories from circulating monocytes to gut macrophages are incompletely understood. Methods Taking advantage of mice depleted for non-classical monocytes due to
Heidbreder K +7 more
europepmc +8 more sources
Glucocorticoid-induced expansion of classical monocytes contributes to bone loss. [PDF]
Exp Mol Med, 2022 Classical monocytes are commonly involved in the innate inflammatory response and are the progenitors of osteoclasts. Excess endogenous glucocorticoids (GCs) can increase the levels of classical monocytes in blood and bone marrow.
Liu P +9 more
europepmc +4 more sources
The slan antigen identifies the prototypical non-classical CD16+-monocytes in human blood [PDF]
Frontiers in Immunology, 2023 IntroductionPeripheral monocytes in humans are conventionally divided into classical (CL, CD14++CD16−), intermediate (INT, CD14++CD16+) and non-classical (NC, CD14dim/−CD16++) cells, based on their expression levels of CD14 and CD16.
Nicola Tamassia +12 more
doaj +5 more sources
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes [PDF]
Scientific Reports, 2020 Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression.
Benjamin J. Ravenhill +4 more
semanticscholar +8 more sources
Revising CX3CR1 Expression on Murine Classical and Non-classical Monocytes [PDF]
Frontiers in Immunology, 2020 In mice, monocytes (Mo) are conventionally described as CX3CR1low classical Mo (CMo) and CX3CR1high non-classical Mo (NCMo) based on the expression of EGFP in Cx3cr1+/EGFP mice and by analogy with human CX3CR1 expression.
Aïda Meghraoui-Kheddar +4 more
doaj +4 more sources
Aging impairs mitochondrial respiratory capacity in classical monocytes [PDF]
Experimental Gerontology, 2018 Aging is a critical healthcare concern, with age‐related inflammation disposing individuals to a variety of diseases. Monocytes are affected by the aging process, with increased inflammation and impaired cellular functions such as phagocytosis ...
Brandt D. Pence, Johnathan R. Yarbro
semanticscholar +4 more sources
Non-classical monocytes as mediators of tissue destruction in arthritis [PDF]
Annals of the Rheumatic Diseases, 2018 Objectives Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage.
A. Puchner +22 more
semanticscholar +7 more sources
Classical monocytes from older adults maintain capacity for metabolic compensation during glucose deprivation and lipopolysaccharide stimulation [PDF]
Mechanisms of Ageing and Development, 2019 Inflammaging is the chronic low-grade inflammation that occurs with age that contributes to the pathology of age-related diseases. Monocytes are innate immune cells that become dysregulated with age and which can contribute to inflammaging.
Brandt Pence
exaly +3 more sources
Anti-β7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing. [PDF]
Clin Transl Med, 2023 Background Closing mucosal defects to reach mucosal healing is an important goal of therapy in inflammatory bowel disease (IBD). Among other cells, monocyte‐derived macrophages are centrally involved in such intestinal wound healing.
Sommer K +14 more
europepmc +2 more sources