Results 51 to 60 of about 137,516 (336)

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

EMBO Molecular Medicine, 2013
We used a novel approach of cytostatically induced leucocyte depletion and subsequent reconstitution with leucocytes deprived of classical (inflammatory/Gr1hi) or non‐classical (resident/Gr1lo) monocytes to dissect their differential role in ...
Oliver Soehnlein, Maik Drechsler, Yvonne Döring, Dirk Lievens, Helene Hartwig, Klaus Kemmerich, Almudena Ortega‐Gómez, Manuela Mandl, Santosh Vijayan, Delia Projahn, Christoph D. Garlichs, Rory R. Koenen, Mihail Hristov, Esther Lutgens, Alma Zernecke, Christian Weber   +15 more
doaj   +1 more source

Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]

, 2019
Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica, Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Letizia, Marilena, Schumann, Michael, Siegmund, Britta   +6 more
core   +1 more source

Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury

Scientific Reports, 2017
Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing outcome.
Claire E. Olingy, Cheryl L. San Emeterio, Molly E. Ogle, Jack R. Krieger, Anthony C. Bruce, David D. Pfau, Brett T. Jordan, Shayn M. Peirce, Edward A. Botchwey   +8 more
doaj   +1 more source

Relationships between serum HMGB1 concentration and subpopulation composition of circulating monocytes in patients with subclinical atherosclerosis

Медицинская иммунология, 2022
Chronic non-infectious inflammation of low intensity is the most important mechanism of development and progression in atherosclerosis. Under the conditions of persistent non-resolving inflammation observed in the vascular wall and atherosclerotic plaque
V. V. Genkel, I. I. Dolgushin, I. L. Baturina, A. Yu. Savochkina, K. V. Nikushkina, A. A. Minasova, L. R. Pykhova, A. S. Kuznetcova, I. I. Shaposhnik   +8 more
doaj   +1 more source

Perivascular adipose tissue inflammation in vascular disease [PDF]

, 2017
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core   +1 more source

Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis

Scientific Reports, 2021
Spondyloarthritis (SpA) is characterized by chronic inflammation and structural damage involving spine and peripheral joints. Monocytes, as part of innate immune system, following migration into affected tissue, may play a role in the pathogenesis of SpA.
Małgorzata Stec, Michał Seweryn, Mariusz Korkosz, Zofia Guła, Rafał Szatanek, Kazimierz Węglarczyk, Magdalena Rutkowska-Zapała, Marzena Lenart, Marcin Czepiel, Jarosław Czyż, Jarosław Baran, Anna Gruca, Kamila Wojnar-Lasoń, Paweł Wołkow, Maciej Siedlar   +14 more
doaj   +1 more source

Mycobacterium leprae alters classical activation of human monocytes in vitro [PDF]

Journal of Inflammation, 2016
Macrophages play a central role in the pathogenesis of leprosy, caused by Mycobacterium leprae. The polarized clinical presentations in leprosy are associated with differential immune activation. In tuberculoid leprosy, macrophages show a classical activation phenotype (M1), while macrophages in lepromatous disease display characteristics of ...
Fallows, Dorothy, Peixoto, Blas, Kaplan, Gilla, Manca, Claudia   +3 more
openaire   +2 more sources

Immunopathogenesis of classical swine fever: role of monocytic cells

Immunology, 1999
Virulent classical swine fever (CSF) represents an immunomodulatory viral infection that perturbs immune functions. Circulatory and immunopathological disorders include leukopenia, immunosuppression and haemorrhage. Monocytic cells – targets for CSF virus (CSFV) infection – could play critical roles in the immunopathology, owing to their production of ...
S M, Knoetig, A, Summerfield, M, Spagnuolo-Weaver, K C, McCullough   +3 more
openaire   +3 more sources

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection [PDF]

, 2015
Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated.
Snelgrove, RJ
core   +1 more source

Selective recruitment of non-classical monocytes promotes skeletal muscle repair [PDF]

Biomaterials, 2017
Regeneration of traumatic defects in skeletal muscle requires the synchronized behavior of multiple cells that participate in repair. The inflammatory cascade that is rapidly initiated after injury serves as a powerful node at which to guide the progression of healing and influence tissue repair. Here, we examine the role that myeloid cells play in the
Cheryl L, San Emeterio, Claire E, Olingy, Yihsuan, Chu, Edward A, Botchwey   +3 more
openaire   +2 more sources