Results 101 to 110 of about 4,411,154 (387)

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus

Frontiers in Immunology, 2016
Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear.
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Mikkel-Ole Skjoedt, Gregory L Stahl, Peter Garred   +5 more
doaj   +1 more source

Innate immune humoral factors, C1q and factor H, with differential pattern recognition properties, alter macrophage response to carbon nanotubes [PDF]

, 2015
Interaction between the complement system and carbon nanotubes (CNTs) can modify their intended biomedical applications. Pristine and derivatised CNTs can activate complement primarily via the classical pathway which enhances uptake of CNTs and ...
Ali-Boucetta, Andersen, Andersen, Andersen, Anthony G. Tsolaki, Balavoine, Basudev Paudyal, Bennie ten Haken, Bianco, Boncel, Cardoso, Carroll, Dumortier, Gaboriaud, Gadjeva, Ghai, Gudrun Stenbeck, Hamad, Haseeb A. Khan, Heister, Heister, Hussain, Jain, Ji, Kagan, Kang, Kirsten M. Pondman, Kishore, Kishore, Kishore, Kishore, Kojouharova, Kouser, Kouser, Lee, Li, Li, Lina Pednekar, Ling, Liu, Lubna Kouser, McDevitt, Moghimi, Mohamed H. Shamji, Muller, Pan, Pantarotto, Pondman, Pondman, Pondman, Pulskamp, Robert B. Sim, Roumenina, Russier, Rybak-Smith, Rybak-Smith, Rybak-Smith, Salvador-Morales, Salvador-Morales, Salvador-Morales, Shi, Sim, Singh, Tan, Tan, Uday Kishore, Verdejo, Wick, Xiao, Zhao, Zolnik   +70 more
core   +2 more sources

Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia [PDF]

Hypertension, 2015
A growing body of evidence suggests that complement dysregulation plays a role in the pathogenesis of preeclampsia. The kidney is one of the major organs affected in preeclampsia. Because the kidney is highly susceptible to complement activation, we hypothesized that preeclampsia is associated with renal complement activation. We performed a nationwide
Penning, M., Chua, J.S., Kooten, C. van, Zandbergen, M., Buurma, A., Schutte, J., Bruijn, J.A., Khankin, E.V., Bloemenkamp, K., Karumanchi, S.A., Baelde, H.   +10 more
openaire   +5 more sources

Robust Gaussian Process Regression method for efficient reaction pathway optimization: application to surface processes [PDF]

arXiv, 2023
Simulation of surface processes is a key part of computational chemistry that offers atomic-scale insights into mechanisms of heterogeneous catalysis, diffusion dynamics, as well as quantum tunneling phenomena. The most common theoretical approaches involve optimization of reaction pathways, including semiclassical tunneling pathways (called instantons)
arxiv  

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Efficient Interaction between Two GTPases Allows the Chloroplast SRP Pathway to Bypass the Requirement for an SRP RNA [PDF]

, 2007
Cotranslational protein targeting to membranes is regulated by two GTPases in the signal recognition particle (SRP) and the SRP receptor; association between the two GTPases is slow and is accelerated 400-fold by the SRP RNA.
Chandrasekar, Sowmya, Jaru-Ampornpan, Peera, Shan, Shu-ou   +2 more
core   +3 more sources

A Randomized, First‐in‐Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway

Clinical pharmacology and therapy, 2018
Aberrant activation of the classical complement pathway is the common underlying pathophysiology of orphan diseases such as bullous pemphigoid, antibody‐mediated rejection of organ transplants, cold agglutinin disease, and warm autoimmune hemolytic ...
Johann Bartko, C. Schoergenhofer, M. Schwameis, C. Firbas, M. Béliveau, Colin Chang, J. Marier, D. Nix, J. Gilbert, S. Panicker, B. Jilma   +10 more
semanticscholar   +1 more source

Mechanisms of pre-mRNA splicing: classical versus non-classical pathways.

Histology and histopathology, 1998
Expression of genetic information proceeds through two major biological events, transcription and translation. However, in eukaryotic cells, the primary transcript (pre-mRNA) is not the template that the translational apparatus scans through, in order to produce the corresponding protein. Pre-mRNAs undergo several modifications (cap site addition, poly
openaire   +4 more sources

Nephritic Factor of the Classical Pathway of Complement [PDF]

Journal of Clinical Investigation, 1980
A factor, functionally characterized by its capacity to stabilize the normally labile classical pathway C3-converting complex of the classical pathway of complement, has been isolated from the serum of one patient with a case of acute glomerulonephritis, subsequent to a cutaneous infection.
Ph. Lesavre, M. Leveillé, L. Halbwachs, J Leibowitch, S. Wattel   +4 more
openaire   +3 more sources

Nonlinear spectroscopy with entangled photons; manipulating quantum pathways of matter [PDF]

arXiv, 2009
Optical signals obtained by the material response to classical laser fields are given by nonlinear response functions which can be expressed by sums over various quantum pathways of matter. We show that some pathways can be selected by using nonclassical fields, through the entanglement of photon and material pathways, which results in a different ...
arxiv