Results 81 to 90 of about 686,133 (287)
, 2015 Recent fluorescence spectroscopy measurements of the turnover time distribution of single-enzyme turnover kinetics of $\beta$-galactosidase provide evidence of Michaelis-Menten kinetics at low substrate concentration.
Dua, Arti +2 more
core +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
A Review of Pyroptosis in Liver Disease [PDF]
BIO Web of ConferencesPyroptosis is a new form of programmed cell death that is different from cell necrosis, apoptosis, and autophagy. It is characterized by the rupture of cell membranes mediated by Gasdermin and the release of cell contents and pro-inflammatory factors ...
Li Hao
doaj +1 more source
Mechanisms of pre-mRNA splicing: classical versus non-classical pathways.
Histology and histopathology, 1998 Expression of genetic information proceeds through two major biological events, transcription and translation. However, in eukaryotic cells, the primary transcript (pre-mRNA) is not the template that the translational apparatus scans through, in order to produce the corresponding protein. Pre-mRNAs undergo several modifications (cap site addition, poly
openaire +3 more sources
Classical and novel GH receptor signaling pathways
Molecular and Cellular Endocrinology, 2020 In this review, I summarize historical and recent features of the classical pathways activated by growth hormone (GH) through the cell surface GH receptor (GHR). GHR is a cytokine receptor superfamily member that signals by activating the non-receptor tyrosine kinase, JAK2, and members of the Src family kinases.
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Demonstration of Jarzynski's Equality in Open Quantum Systems Using a Step-Wise Pulling Protocol
, 2012 We present a generalization of Jarzynski's Equality, applicable to quantum systems, relating discretized mechanical work and free-energy changes. The theory is based on a step-wise pulling protocol.
Haas, Stephan, Ngo, Van A.
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Platelets at the vascular interface [PDF]
, 2018 ..
Bergmeier, Wolfgang, Stefanini, Lucia
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Critical time window for NO-cGMP-dependent long-term memory formation after one-trial appetitive conditioning [PDF]
, 2002 The nitric oxide (NO)-cGMP signaling pathway is implicated in an increasing number of experimental models of plasticity. Here, in a behavioral analysis using one-trial appetitive associative conditioning, we show that there is an obligatory requirement ...
Andrew, Richard J +4 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source