Results 11 to 20 of about 63,639 (257)
Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers
Cell Reports, 2012 Clathrin/AP1- and clathrin/AP3-coated vesicular carriers originate from endosomes and the trans-Golgi network. Here, we report the real-time visualization of these structures in living cells reliably tracked by rapid, three-dimensional imaging with the ...
Comert Kural +6 more
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Clathrin exchange during clathrin-mediated endocytosis [PDF]
The Journal of Cell Biology, 2001 During clathrin-mediated endocytosis, clathrin-coated pits invaginate to form clathrin-coated vesicles (CVs). Since clathrin-coated pits are planar structures, whereas CVs are spherical, there must be a structural rearrangement of clathrin as invagination occurs.
Wu, Xufeng +5 more
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Clathrin Adaptor GGA1 Polymerizes Clathrin into Tubules [PDF]
Journal of Biological Chemistry, 2007 GGAs, a class of monomeric clathrin adaptors, are involved in the sorting of cargo at the trans-Golgi network of eukaryotic cells. They are modular structures consisting of the VHS, the GAT, hinge, and GAE domains, which have been shown to interact directly with cargo, ARF, clathrin, and accessory proteins, respectively.
Fang, Zhang +5 more
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The ∼ 16 kDa C-terminal sequence of clathrin assembly protein AP180 is essential for efficient clathrin binding. [PDF]
PLoS ONE, 2014 Brain-specific AP180 is present in clathrin coats at equal concentration to the adapter complex, AP2, and assembles clathrin faster than any other protein in vitro.
Ling-Shan Chan +3 more
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Clathrin Senses Membrane Curvature [PDF]
Biophysical Journal, 2020 ABSTRACTThe ability of proteins to sense membrane curvature is essential to diverse membrane remodeling processes including clathrin-mediated endocytosis. Multiple adaptor proteins within the clathrin pathway have been shown to assemble together at curved membrane sites, leading to local recruitment of the clathrin coat.
Wade F, Zeno +7 more
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Clathrin-dependent endocytosis [PDF]
Biochemical Journal, 2004 The process by which clathrin-coated vesicles are produced involves interactions of multifunctional adaptor proteins with the plasma membrane, as well as with clathrin and several accessory proteins and phosphoinositides. Here we review recent findings highlighting new insights into mechanisms underlying clathrin-dependent endocytosis.
Seyed Ali, Mousavi +3 more
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eLife, 2014 The discovery of an ancient protein complex reveals the evolutionary relationships between the proteins that help to form vesicles.
Thomas U Schwartz
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Brain clathrin and clathrin-associated proteins. [PDF]
Biochemical Journal, 1982 The assembly of clathrin into baskets or cages in vitro may depend on formation of complex between clathrin and a polypeptide doublet migrating in the 30000-mol.wt. region. Clathrin with several associated proteins was isolated from coated-vesicle fractions of bovine cerebral cortex.
M P, Lisanti +4 more
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The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells
Membranes, 2014 Receptor-mediated endocytosis in renal proximal tubule epithelial cells (PTECs) is important for the reabsorption and metabolization of proteins and other substances, including carrier-bound vitamins and trace elements, in glomerular filtrates ...
Shankhajit De +2 more
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Flat clathrin lattices are linked to metastatic potential in colorectal cancer
iScience, 2023 Summary: Clathrin assembles at the cells’ plasma membrane in a multitude of clathrin-coated structures (CCSs). Among these are flat clathrin lattices (FCLs), alternative clathrin structures that have been found in specific cell types, including cancer ...
Charlotte Cresens +6 more
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