Membrane Heterogeneity Controls Cellular Endocytic Trafficking
Frontiers in Cell and Developmental Biology, 2020 Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations defined by specific lipid and protein compositions.
Gregory M. I. Redpath +7 more
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The ∼ 16 kDa C-terminal sequence of clathrin assembly protein AP180 is essential for efficient clathrin binding. [PDF]
PLoS ONE, 2014 Brain-specific AP180 is present in clathrin coats at equal concentration to the adapter complex, AP2, and assembles clathrin faster than any other protein in vitro.
Ling-Shan Chan +3 more
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Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. [PDF]
, 2012 Clathrin coat accessory proteins play key roles in transport mediated by clathrin-coated vesicles. Yeast Irc6p and the related mammalian p34 are putative clathrin accessory proteins that interact with clathrin adaptor complexes.
Cascio, Duilio +5 more
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Regulation of Clathrin-Mediated Endocytosis.
Annual Review of Biochemistry, 2018 Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It is responsible for the uptake of transmembrane receptors and transporters, for remodeling plasma membrane composition in response to environmental changes, and for ...
Marcel Mettlen +4 more
semanticscholar +1 more source
Clathrin-independent pathways do not contribute significantly to endocytic flux
eLife, 2014 Several different endocytic pathways have been proposed to function in mammalian cells. Clathrin-coated pits are well defined, but the identity, mechanism and function of alternative pathways have been controversial.
Vassilis Bitsikas +2 more
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Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement [PDF]
, 2017 The current model for vesicular traffic to and from the plasma membrane is accepted but the molecular requirements for this coordination are not well defined.
Blatt, Michael R. +4 more
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eLife, 2014 The discovery of an ancient protein complex reveals the evolutionary relationships between the proteins that help to form vesicles.
Thomas U Schwartz
doaj +1 more source
SNX4 in complex with clathrin and dynein: implications for endosome movement. [PDF]
PLoS ONE, 2009 BACKGROUND:Sorting nexins (SNXs) constitute a family of proteins classified by their phosphatidylinositol (PI) binding Phox homology (PX) domain. Some members regulate intracellular trafficking.
Sigrid S Skånland +3 more
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Flat clathrin lattices are linked to metastatic potential in colorectal cancer
iScience, 2023 Summary: Clathrin assembles at the cells’ plasma membrane in a multitude of clathrin-coated structures (CCSs). Among these are flat clathrin lattices (FCLs), alternative clathrin structures that have been found in specific cell types, including cancer ...
Charlotte Cresens +6 more
doaj +1 more source
Activation of endocytosis as an adaptation to the mammalian host by trypanosomes [PDF]
, 2007 Immune evasion in African trypanosomes is principally mediated by antigenic variation, but rapid internalization of surface-bound immune factors may contribute to survival.
Field, Mark C +4 more
core +2 more sources