Results 41 to 50 of about 134,599 (345)

Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine [PDF]

, 2012
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin (IgG) across epithelia to confer passive immunity to mammalian young. In newborn rodents, FcRn transcytoses IgG from ingested milk across the intestinal epithelium for release into the ...
Bjorkman, Pamela J., Huey-Tubman, Kathryn E., Ladinsky, Mark S.   +2 more
core   +2 more sources

Evidence for ESCRT- and clathrin-dependent microautophagy

Journal of Cell Biology, 2017
Microautophagy refers to a mode of autophagy in which the lysosomal or vacuolar membrane invaginates and directly engulfs target components. The molecular machinery of membrane dynamics driving microautophagy is still elusive.
Masahide Oku, Y. Maéda, Yoko Kagohashi, T. Kondo, Mai Yamada, T. Fujimoto, Y. Sakai   +6 more
semanticscholar   +1 more source

Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization.

PLoS Pathogens, 2009
Many viruses that enter cells by clathrin-dependent endocytosis are significantly larger than the dimensions of a typical clathrin-coated vesicle.
David K Cureton, Ramiro H Massol, Saveez Saffarian, Tomas L Kirchhausen, Sean P J Whelan   +4 more
doaj   +1 more source

A Pan1/End3/Sla1 complex links Arp2/3-mediated actin assembly to sites of clathrin-mediated endocytosis. [PDF]

, 2015
More than 60 highly conserved proteins appear sequentially at sites of clathrin-mediated endocytosis in yeast and mammals. The yeast Eps15-related proteins Pan1 and End3 and the CIN85-related protein Sla1 are known to interact with each other in vitro ...
Drubin, David G, Leong, Nicole T, Sun, Yidi, Wong, Tiffany   +3 more
core   +2 more sources

Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis

Nature Communications, 2018
Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it was long believed that clathrin-coated pits grow with a constant curvature, it was recently ...
Delia Bucher, F. Frey, Kem A. Sochacki, Susann Kummer, Jan-Philip Bergeest, William J. Godinez, H. Kräusslich, K. Rohr, Justin W. Taraska, U. Schwarz, S. Boulant   +10 more
semanticscholar   +1 more source

Large self-assembled clathrin lattices spontaneously disassemble without sufficient adaptor proteins.

PLoS Computational Biology, 2022
Clathrin-coated structures must assemble on cell membranes to internalize receptors, with the clathrin protein only linked to the membrane via adaptor proteins.
Si-Kao Guo, Alexander J Sodt, Margaret E Johnson   +2 more
doaj   +1 more source

Membrane remodeling in clathrin-mediated endocytosis

Journal of Cell Science, 2018
Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic cells regulate their plasma membrane composition to control processes ranging from cell signaling to adhesion, migration and morphogenesis.
V. Haucke, M. Kozlov
semanticscholar   +1 more source

Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

Molecular Cancer, 2013
Background During metaphase clathrin stabilises the mitotic spindle kinetochore(K)-fibres. Many anti-mitotic compounds target microtubule dynamics.
Smith Charlotte M, Haucke Volker, McCluskey Adam, Robinson Phillip J, Chircop Megan   +4 more
doaj   +1 more source

Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling. [PDF]

PLoS ONE, 2011
Endocytosis of tyrosine kinase receptors can influence both the duration and the specificity of the signal emitted. We have investigated the mechanisms of internalization of fibroblast growth factor receptor 3 (FGFR3) and compared it to that of FGFR1 ...
Ellen Margrethe Haugsten, Malgorzata Zakrzewska, Andreas Brech, Sascha Pust, Sjur Olsnes, Kirsten Sandvig, Jørgen Wesche   +6 more
doaj   +1 more source

Dynamin recruitment by clathrin coats: a physical step? [PDF]

, 2003
Recent structural findings have shown that dynamin, a cytosol protein playing a key-role in clathrin-mediated endocytosis, inserts partly within the lipid bilayer and tends to self-assemble around lipid tubules. Taking into account these observations, we
Dommersnes, P. -G., Fournier, J. -B., Galatola, P.   +2 more
core   +2 more sources