Results 51 to 60 of about 126,267 (387)
Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2
Journal of Cell Biology, 2017 The critical initiation phase of clathrin-mediated endocytosis (CME) determines where and when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathrin-coated pit (CCP) assembly, are activated by conformational ...
Z. Kadlecová +5 more
semanticscholar +1 more source
The cellular functions of clathrin [PDF]
Cellular and Molecular Life Sciences, 2006 Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking.
openaire +3 more sources
A Pan1/End3/Sla1 complex links Arp2/3-mediated actin assembly to sites of clathrin-mediated endocytosis. [PDF]
, 2015 More than 60 highly conserved proteins appear sequentially at sites of clathrin-mediated endocytosis in yeast and mammals. The yeast Eps15-related proteins Pan1 and End3 and the CIN85-related protein Sla1 are known to interact with each other in vitro ...
Drubin, David G +3 more
core +2 more sources
Nature Communications, 2019 Clathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Unique functions for these evolutionary conserved paralogs remain elusive, and their role in clathrin-mediated endocytosis in mammalian cells is debated.
M. Biancospino +10 more
semanticscholar +1 more source
PLoS Pathogens, 2009 Many viruses that enter cells by clathrin-dependent endocytosis are significantly larger than the dimensions of a typical clathrin-coated vesicle.
David K Cureton +4 more
doaj +1 more source
PLoS Computational Biology, 2022 Clathrin-coated structures must assemble on cell membranes to internalize receptors, with the clathrin protein only linked to the membrane via adaptor proteins.
Si-Kao Guo +2 more
doaj +1 more source
Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis [PDF]
, 2018 Disabled-1 (Dab1) is an essential intracellular adaptor protein in the reelin pathway. Our previous studies in mice intestine showed that Dab1 transmits the reelin signal to cytosolic signalling pathways.
Balda, María S. +5 more
core +1 more source
Membrane bending occurs at all stages of clathrin-coat assembly and defines endocytic dynamics
Nature Communications, 2018 Clathrin-mediated endocytosis (CME) internalizes plasma membrane by reshaping small regions of the cell surface into spherical vesicles. The key mechanistic question of how coat assembly produces membrane curvature has been studied with molecular and ...
Brandon L. Scott +10 more
semanticscholar +1 more source
Architecture of coatomer: Molecular characterization of delta-COP and protein interactions within the complex [PDF]
, 1996 Copyright © 2011 by The Rockefeller University Press.Coatomer is a cytosolic protein complex that forms the coat of COP I-coated transport vesicles.
Auerbach, S +9 more
core +1 more source
β-arrestin drives MAP kinase signaling from clathrin-coated structures after GPCR dissociation
Nature Cell Biology, 2016 β-Arrestins critically regulate G-protein-coupled receptor (GPCR) signalling, not only ‘arresting’ the G protein signal but also modulating endocytosis and initiating a discrete G-protein-independent signal through MAP kinase.
Kelsie Eichel +2 more
semanticscholar +1 more source