Results 241 to 250 of about 21,285,591 (295)
The Journal of Physiology, EarlyView.Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos +4 more
wiley +1 more source
Colonic Perineurioma Presenting as a Small Subepithelial Lesion With Distinctive Endoscopic Findings
DEN Open, Volume 7, Issue 1, April 2027.ABSTRACT A 59‐year‐old man with a history of colorectal polypectomy underwent a screening colonoscopy. A 5‐mm reddish lesion was identified in the sigmoid colon. The lesion had a smooth surface without erosion or ulceration and appeared slightly elevated with well‐demarcated margins.
Hironobu Takedomi +4 more
wiley +1 more source
Development of tight junction-strengthening compounds using a high-throughput screening system to evaluate cell surface-localized claudin-1 in keratinocytes. [PDF]
Sci RepSakamoto H, Nishikawa M, Yamada S.
europepmc +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 8, August 2026.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source
eFood, Volume 7, Issue 4, August 2026.Lactic acid bacteria (LAB) fermentation cleaves specific glycosidic bonds in Dendrobium officinale polysaccharides (DOPs), reducing molecular weight and enhancing anti‐inflammatory activity through regulation of inflammatory cytokines, oxidative stress, and intestinal barrier function.
Dingding Hong, Hui Ye, Xiaojun Huang
wiley +1 more source
Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley +1 more source
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Impairment of hepato‐intestinal homeostasis triggered by ST2 deficiency during T. cruzi infection. Within the splenic compartment, immune dysregulation is marked by a robust pro‐inflammatory polarization of the T‐cell landscape. In the liver, ST2 deficiency is associated with hepatocellular injury, increased parasite burden, and hyperalbuminemia ...
Marcelo Eduardo Cardozo +22 more
wiley +1 more source
The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.Abstract Primary signet‐ring cell carcinoma and poorly differentiated adenocarcinoma with poorly cohesive morphology in the cervix are rare conditions, and their clinicopathological features remain poorly described. This study defines primary cervical poorly differentiated adenocarcinomas meeting the diagnostic criteria for poorly cohesive carcinoma as
Wei Liu +14 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 7, Page 1414-1427, July 2026.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source