Results 251 to 260 of about 21,285,591 (295)

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, Volume 13, Issue 37, 3 July 2026.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

Alpinia zerumbet‐Derived Extracellular Vesicles Protect Against UVB‐Induced Photoaging by Enhancing Mitochondrial Bioenergetics and Skin Barrier Function

BioFactors, Volume 52, Issue 4, July/August 2026.
AZEVs derived from Alpinia zerumbet leaves protect HaCaT keratinocytes from UVB‐induced photoaging by reducing reactive oxygen species (ROS) accumulation, restoring mitochondrial membrane potential, and enhancing ATP production. AZEVs upregulate mitochondrial biogenesis–related proteins, including p‐AMPK/AMPK, SIRT1, PGC‐1α, and Nrf2, thereby improving
Mo‐Rong Xu, Hui‐Chun Wang, Meng‐Shiou Lee, Sheng‐Yang Wang   +3 more
wiley   +1 more source

Association of the PD‐L1 CPS With the Efficacy of First‐Line Nivolumab Plus Chemotherapy for Unresectable Advanced or Recurrent Gastric Cancer

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background The CheckMate 649 trial showed the superiority of first‐line nivolumab plus chemotherapy (Nivo‐CT) over chemotherapy alone for advanced gastric or gastroesophageal junction (GEJ) cancer with a programmed cell death‐ligand 1 (PD‐L1) combined positive score (CPS) ≥ 5.
Nozomu Ogura, Misa Ohnishi, Rin Inamoto, Yosuke Kito, Kengo Nagashima, Naoki Takahashi, Mitsuhiro Furuta, Hirokazu Shoji   +7 more
wiley   +1 more source

Exposure to Progestin 17-OHPC Induces Gastrointestinal Dysfunction through Claudin-1 Suppression in Female Mice with Increased Anxiety-Like Behaviors.

Neuroendocrinology
Zeng L, Zhang X, Shen Q, He L, Liu X, Zeng X, Wu Q, Ma I, Zheng S, Cheng L, Li L, Yao P.   +11 more
europepmc   +1 more source

Pro-apoptotic effect of Δ2-TGZ in “claudin-1-low” triple-negative breast cancer cells: involvement of claudin-1 [PDF]

Breast Cancer Research and Treatment, 2017
40% of triple-negative breast cancer (TNBC) do not express claudin-1, a major constituent of tight junction. Patients with these "claudin-1-low" tumors present a higher relapse incidence. A major challenge in oncology is the development of innovative therapies for such poor prognosis tumors. In this context, we study the anticancer effects of ∆2-TGZ, a
Geoffroy, Marine, Kleinclauss, Alexandra, Grandemange, Stéphanie, Hupont, Sébastien, Boisbrun, Michel, Flament, Stéphane, Grillier-Vuissoz, Isabelle, Kuntz, Sandra   +7 more
openaire   +4 more sources

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Loss of claudin‐1 in lipopolysaccharide‐treated periodontal epithelium

Journal of Periodontal Research, 2011
Fujita T, Firth JD, Kittaka M, Ekuni D, Kurihara H, Putnins EE. Loss of claudin‐1 in lipopolysaccharide‐treated periodontal epithelium. J Periodont Res 2012; 47: 222–227. © 2011 John Wiley & Sons A/SBackground and Objective:  The epithelial barrier is a critical component of innate immunity and provides protection against microbial invasion ...
T, Fujita, J D, Firth, M, Kittaka, D, Ekuni, H, Kurihara, E E, Putnins   +5 more
openaire   +2 more sources

EXPRESSION OF CLAUDIN-1 IN MOUSE TESTIS

Archives of Andrology, 2003
In testis, tight junctions (TJs) between adjacent Sertoli cells are important for the formation of the blood-testis barrier (BTB) and crucial for spermatogenesis. The present study aimed to find postnatal changes in the expression of claudin-1, one of the TJ genes in mouse testis.
openaire   +2 more sources

The expressions of claudin-1 and E-cadherin in junctional epithelium

Journal of Periodontal Research, 2010
The epithelium provides an important barrier against microbial invasion. Tight junction structural proteins called claudins are known to contribute to the epithelial cell barrier. Junctional epithelium is located at a strategically important interface between gingival sulcus and is interconnected by desmosomes and gap junctions, but not by tight ...
T, Fujita, K, Hayashida, H, Shiba, A, Kishimoto, S, Matsuda, K, Takeda, H, Kawaguchi, H, Kurihara   +7 more
openaire   +2 more sources

Regulatory roles of claudin-1 in cell adhesion and microvilli formation

Biochemical and Biophysical Research Communications, 2021
Aberrant expression of tight junction proteins has recently been focused on in the cancer research field. We previously showed that claudin-1 is aberrantly expressed from an early stage of uterine cervical adenocarcinoma and contributes to malignant potentials.
Kumi Takasawa, Akira Takasawa, Taishi Akimoto, Kazufumi Magara, Tomoyuki Aoyama, Hiroshi Kitajima, Taro Murakami, Yusuke Ono, Daisuke Kyuno, Hiromu Suzuki, Makoto Osanai   +10 more
openaire   +2 more sources