Results 151 to 160 of about 78,811 (306)

Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications

Cell Proliferation, EarlyView.
This review highlights emerging strategies to engineer vascularized brain organoids—including endothelial co‐culture, genetic induction, perfusion systems, and in vivo transplantation—and their applications in modelling neurovascular diseases, evaluating BBB drug delivery, and advancing regenerative medicine.
Yeajin Song, Hyejin Jo, Seokchan Jeong, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Claudin gene expression profiles and clinical value in colorectal tumors classified according to their molecular subtype

Cancer Management and Research, 2019
Sara Cherradi, Pierre Martineau, Céline Gongora, Maguy Del Rio Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier F ...
Cherradi S, Martineau P, Gongora C, Del Rio M   +3 more
doaj  

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

Claudin-6 [PDF]

, 2020
openaire   +1 more source

Claudin‐18 expression in gastric type adenocarcinoma and HPV‐associated adenocarcinoma of the uterine cervix

Histopathology, EarlyView.
CLDN18 (43‐14A) is expressed in most gastric type adenocarcinomas and a much smaller proportion of HPV‐associated adenocarcinomas. Expression of CLDN18.2 mRNA but not CLDN18.1 mRNA is confirmed in both gastric type adenocarcinomas and HPV‐associated adenocarcinomas.
Nobuko Yasutake, Yuki Yokawa, Takehiro Tanaka, Riri Mishima, Misato Komamizu, Ryosuke Kuga, Rina Jiromaru, Shinichiro Kawatoko, Kenzo Sonoda, Hideaki Yahata, Kiyoko Kato, Yoshinao Oda, Hidetaka Yamamoto   +12 more
wiley   +1 more source

Molecular pathology of phyllodes tumours of the breast—much more than MED12

Histopathology, EarlyView.
Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang, Kylie L Gorringe, Puay Hoon Tan, Stephen B Fox   +3 more
wiley   +1 more source

Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma. [PDF]

World J Gastrointest Oncol
Selvam S, Vairappan B.
europepmc   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance. [PDF]

J Exp Med
Březina J, Brabec T, Machač D, Vobořil M, Ballek O, Pačes J, Sýkora V, Jančovičová K, Valter E, Kováčová K, Manning J, Tahtahová V, Čepková A, Dobešová M, Dobeš J, Kubovčiak J, Kolář M, Kašpárek P, Sedlacek R, Štepánek O, Černý J, Tsukita S, Malissen B, Anderson G, Filipp D.   +24 more
europepmc   +1 more source