Results 241 to 250 of about 56,637 (316)

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

Investigation of <italic>CLDN5</italic> Gene 3' Untranslated Region rs10314 Polymorphism and Protein Levels in Children and Adolescents with Attention-Deficit Hyperactivity Disorder: A Molecular and Clinical Correlation Study. [PDF]

Med Princ Pract
Göktaş E, Uzun N, Kurnaz Demir TD, Hira Selen AT, Kılınç İ, Kılıç AO.   +5 more
europepmc   +1 more source

Gastrointestinal microbiota and barrier integrity in individuals who develop exertional heat illness and pair‐matched controls: A prospective observational cohort study

Experimental Physiology, EarlyView.
Abstract It has been hypothesised that the composition of the gastrointestinal (GI) microbiota contributes to exertional heat illness (EHI) aetiology, but relevant empirical data in humans are lacking. Utilising a unique prospective study design, stool samples and resting blood samples were obtained from 550 individuals prior to (within 3 days ...
Alex A. M. Gould, Neil P. Walsh, Michael J. Tipton, Michael J. Zurawlew, Samuel C. Robson, Janis K. Shute, Joy E. M. Watts, Hayley C. Tyson, Megan R. Robinson, Andrew J. Roberts, Alex J. Rawcliffe, Ross Hemingway, Jo Corbett   +12 more
wiley   +1 more source

Simulated Mars Gravity Impairs Intestinal Epithelial Barrier Integrity via Selective Modulation of Tight Junction Components. [PDF]

Biomolecules
Benvenuti L, Bertini C, Marcelli G, Ippolito C, Citi V, Giovannoni R, Iacopetti P, Gambino G, Rossi L, Angeloni D, Manzoni D, Salvetti A.   +11 more
europepmc   +1 more source

Plant‐protein supplementation improves thermoregulatory responses and ameliorates markers of intestinal damage during exercise in the heat

Experimental Physiology, EarlyView.
Abstract Exercise in the heat often causes gastrointestinal (GI) disturbances, which can impair performance. Single amino acid supplementation can attenuate gut damage and enhance exercise tolerance; however, the effectiveness of innate amino acid blends from plant‐based proteins remains underexplored.
Robyn Aitkenhead, Mark Waldron, Gillian E. Conway, Katy Horner, Shane M. Heffernan   +4 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Nanoscopic analysis of tight junction organization in in vitro blood-brain barrier models. [PDF]

Fluids Barriers CNS
Waldow A, Brachner A, Perriere N, Neuhaus W, Piontek J.   +4 more
europepmc   +1 more source

Preeclampsia‐derived small extracellular vesicles disrupt blood–brain barrier integrity and activate glial cells in vitro

The Journal of Physiology, EarlyView.
Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo, José M. Murrieta‐Coxca, Christian Schmeer, Lingyu Wei, Frank Steiniger, Tanja Groten, Udo R. Markert, Diana M. Morales‐Prieto   +7 more
wiley   +1 more source

Immunological and molecular biomarkers in skin allergy therapy: monitoring inflammation, barrier function, and treatment response. [PDF]

Postepy Dermatol Alergol
Lisiecka MZ.
europepmc   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source