Results 131 to 140 of about 20,650 (306)

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

open access: yesFood Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

open access: yesFood Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso   +3 more
wiley   +1 more source

Cannabidiol Strengthening of Gastric Tight Junction Complexes Analyzed in an Improved Xenopus Oocyte Assay

open access: yesMembranes
Cannabidiol (CBD), the non-psychoactive compound derived from the cannabis plant, has gained attention in recent years as a remedy against gastrointestinal disorders ranging from nausea and inflammation to abdominal pain.
Laura Stein   +2 more
doaj   +1 more source

Role of membrane components in the initiation and progression of tumour growth in endometrial cancer

open access: yesНаука и инновации в медицине
This review discusses the role of membrane components in the initiation and progression of endometrial cancer. Cancer cells that are the substrate of the tumor growth are subject to multiple interactions both among themselves and with the tumor ...
Ilyas B. Atadzhanov   +2 more
doaj   +1 more source

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

open access: yesiMetaOmics, EarlyView.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng   +15 more
wiley   +1 more source

Engineered Bacillus subtilis regulates intestinal barrier in ETEC K88‐infected piglets and modulates miR‐1250‐5p/NFκB pathway in IPEC‐J2

open access: yesiMetaOmics, EarlyView.
Upon enterotoxigenic Escherichia coli (ETEC) K88 infection, intestinal barrier function is disrupted with compromised tight junctions, accompanied by an exacerbated inflammatory response, proliferation of pathogenic Escherichia, and depletion of beneficial Lactobacillus paralimentarius.
Chaoyue Wen   +11 more
wiley   +1 more source

Role of tight junctions in signal transduction: an update [PDF]

open access: yes, 2014
Tight junctions (TJs), which are the most apically located of the intercellular junctional complexes, have a barrier function and a fence function. Recent studies show that they also participate in signal transduction mechanisms.
Himi, Tetsuo   +3 more
core  

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

open access: yesiMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin   +13 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

open access: yesiNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong   +5 more
wiley   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

open access: yesiNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang   +7 more
wiley   +1 more source

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