Results 41 to 50 of about 895,341 (164)

Microbial Degradation of Chloroaromatics: Use of the meta-Cleavage Pathway for Mineralization of Chlorobenzene [PDF]

, 1997
Pseudomonas putida GJ31 is able to simultaneously grow on toluene and chlorobenzene. When cultures of this strain were inhibited with 3-fluorocatechol while growing on toluene or chlorobenzene, 3-methylcatechol or 3-chlorocatechol, respectively ...
Kasberg, Thomas,, Agteren, Martin H. van,, Kaschabek, Stefan R., Mars, Astrid E.,, Mars, Astrid E., Janssen, Dick B., Reineke, Walter,, Reineke, Walter, Agteren, Martin H. van, Kaschabek, Stefan R.,, Kasberg, Thomas, Janssen, Dick B.,   +11 more
core   +1 more source

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Fisher, LM, Dias, M, PAN X. S, Pan, XS, Palumbo, M, DIAS M, FISHER L. M., PALUMBO, MANLIO   +7 more
core   +1 more source

Biosynthesis of retinoic acid by intestinal enzymes of the rat

Journal of Lipid Research, 1967
The incubation of Β-carotene-14C with the soluble fraction of the intestinal mucosa resulted in the formation of small amounts of acidic material. The addition of NAD or NADH to the soluble fraction caused a tenfold increase in this material.
F.D. Crain, F.J. Lotspeich, R.F. Krause
doaj   +1 more source

Two-Metal Ion Mechanism of DNA Cleavage in CRISPR-Cas9 [PDF]

, 2019
CRISPR-Cas9 is a cutting-edge genome-editing technology, which employs the endonuclease Cas9 to cleave DNA sequences of interest. However, the catalytic mechanism of DNA cleavage and the critical role of the Mg2+ ions have remained elusive. Here, quantum–
Lorenzo, Casalino, Giulia, Palermo, Martin, Jinek   +2 more
core   +1 more source

Metal-Assisted Hydrolysis Reactions Involving Lipids: A Review

Frontiers in Chemistry, 2019
This report covers major advances in the use of metal ions and complexes to hydrolyze ester and phosphate ester lipid bonds. These metal-based Lewis acids have been investigated as catalysts to isolate fatty acids from biological sources, as probes to ...
Dominique E. Williams, Kathryn B. Grant
doaj   +1 more source

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat [PDF]

, 2010
Background: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-
Sakalian Michael, Karl Salzwedel, Salzwedel Karl, Catherine S. Adamson, Eric O. Freed, Sakalian, M, Michael Sakalian, Adamson, Catherine S, Salzwedel, K, Freed Eric O, Freed, E.O., Adamson Catherine S   +11 more
core   +1 more source

PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein

mBio
Selective autophagy is a critical host defense mechanism that eliminates viral components through lysosomal degradation during coronavirus infection. Coronaviruses (CoVs), however, deploy countermeasures that disrupt this process, and several underlying ...
Ke Li, Hongyun Wei, Kangli Zhao, Dong Chen, Yu Sun, Peng Zhou, Hui Jin, Anan Jongkaewwattana, Sizhu Suolang, Dang Wang, Hongbo Zhou, Rui Luo   +11 more
doaj   +1 more source

Contribution of Slip and Cleavage in Friction and Wear at (1 0 -1 4) Surface of Magnesite (MgCO3) Crystal

Tribology Online, 2011
Frictional force was measured using Bowden-Leben apparatus with a sapphire stylus at directional (1 0 -1 4) surface of magnesite crystal. Deformation patterns formed during the scratch in ± [4 2 -1] directions were observed with optical microscopy.
Kaori Niki, Mai Kobayashi, Hitoshi Shindo   +2 more
doaj   +1 more source

Seneca Valley virus 3C protease targets TRIM32 for cleavage to antagonize its antiviral effects

Journal of Virology
The Seneca Valley virus (SVV), a newly emerged virus within the Picornaviridae family, causes porcine idiopathic vesicular disease, imposing substantial economic costs to the global pork industry.
Jingjing Yang, Zijian Li, Ruiyi Ma, Shijie Xie, Dan Wang, Rong Quan, Jue Liu, Jiangwei Song   +7 more
doaj   +1 more source

Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]

, 2005
Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Mann, Karlheinz, Mann, K., Ghosh, M., Machleidt, W., Machleidt, Werner, Siwanowicz, I., Ghosh, Madhumita, Holak, Tad A., Holak, T. A., Holak, T., Siwanowicz, Igor, Shanker, Sreejesh, Shanker, S.   +12 more
core   +1 more source