Results 91 to 100 of about 4,680 (201)

Identification of platelet function defects by multi-parameter assessment of thrombus formation. [PDF]

, 2014
Assays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi-parameter flow assay to characterize thrombus formation in whole blood from ...
Baaten, Constance, Cavill, Rachel, Clemetson, Kenneth J, Coort, Susan, Cosemans, Judith MEM, de Witt, Susanne M, Farndale, Richard W, Heemskerk, Johan WM, Jurk, Kerstin, Lamers, Moniek ME, Mastenbroek, Tom, Pugh, Nicholas, Scharrer, Inge, Schulz, Ansgar, Swieringa, Frauke, van Kruchten, Roger, Zieger, Barbara   +16 more
core   +4 more sources

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, Volume 58, Issue 9, September 2025.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Characterization and visualization of murine coagulation factor VIII-producing cells in vivo

Scientific Reports, 2021
Coagulation factors are produced from hepatocytes, whereas production of coagulation factor VIII (FVIII) from primary tissues and cell species is still controversial.
Morisada Hayakawa, Asuka Sakata, Hiroko Hayakawa, Hikari Matsumoto, Takafumi Hiramoto, Yuji Kashiwakura, Nemekhbayar Baatartsogt, Noriyoshi Fukushima, Yoichi Sakata, Katsue Suzuki-Inoue, Tsukasa Ohmori   +10 more
doaj   +1 more source

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, Volume 12, Issue 30, August 14, 2025.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

A role of platelet C-type lectin-like receptor-2 and its ligand podoplanin in vascular biology [PDF]

Purpose of review Platelets are essential for hemostasis and are also vital in lymphatic and lung development and the maintenance of vascular integrity.
20710362, 23909, Suzuki-Inoue, Katsue, Tsukiji, Nagaharu, ツキジ, ナガハル, 築地, 長治   +5 more
core   +1 more source

Functional redundancy between RAP1 isoforms in murine platelet production and function [PDF]

, 2018
RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a ...
Becker, Bergmeier, Bermejo, Bertozzi, Bertozzi, Bokoch, Bos, Boudreaux, Boulaftali, Boulaftali, Bouschet, Burkhart, Canault, Cattaneo, Christopher I. Jones, Chrzanowska-Wodnicka, Chrzanowska-Wodnicka, Crittenden, Dan O. Kechele, David S. Paul, Deppermann, Dorsaf Ghalloussi, Durrant, Ellen C. O'Shaughnessy, Eto, Garcia, Getz, Gloerich, Goerge, Gros, Han, Ho-Tin-Noé, Jonathan M. Gibbins, Kamata, Kamata, Kasirer-Friede, Kathleen M. Caron, Kathryn O. Poe, Kato, Klapproth, Klaus M. Hahn, Lee, Lee, Lenter, Li, Li, Lin, Lozano, Lucia Stefanini, Mazharian, Molina-Ortiz, Moore, Moser, Nieswandt, Nieswandt, Nonaka, Pan, Petrich, Piatt, Pleines, Qu, Raaijmakers, Raymond Piatt, Robert H. Lee, Rowley, Shattil, Simon, Stalker, Stefanini, Stefanini, Stefanini, Stefanini, Stefanini, Stolla, Stork, Stritt, Su, Suzuki-Inoue, Séverin, Taira, Tiedt, Wang, Watanabe, Watkins, Westbury, Wittchen, Wolfgang Bergmeier, Yacine Boulaftali, Yue, Zeiler, Zhang, Zhu   +91 more
core   +1 more source

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice [PDF]

Blood, 2017
Key Points An inactivating point mutation in the hemITAM motif of murine CLEC-2 reproduces the lymphatic defects seen in CLEC-2–deficient mice. CLEC-2 contributes to thrombus stability in vivo independently of hemITAM signaling.
Elizabeth J. Haining, Deya Cherpokova, Karen Wolf, Isabelle C. Becker, Sarah Beck, Johannes A. Eble, David Stegner, Steve P. Watson, Bernhard Nieswandt   +8 more
openaire   +2 more sources

Integrating Single‐Cell Transcriptomics and Machine Learning to Define an ac4C Gene Signature in Lung Adenocarcinoma

Thoracic Cancer, Volume 16, Issue 15, August 2025.
This study combines single‐cell RNA sequencing and bulk transcriptomics to investigate the role of ac4C RNA modification in lung adenocarcinoma. Using 10 machine learning algorithms, an ac4C‐related gene signature (ARGSig) was constructed and validated for prognosis prediction.
Yuan Wang, Wei Su, Guangyao Zhou, Yijie Wang, Chunnuan Wu, Pengpeng Zhang, Lianmin Zhang   +6 more
wiley   +1 more source

The multiple faces of leukocyte interstitial migration

, 2014
Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into and within sites of inflammation and infection rely on signaling in ...
Germain, R., Lämmermann, T.
core   +1 more source

Pattern recognition receptors in antifungal immunity [PDF]

, 2014
We thank the Wellcome Trust for funding this study.Peer reviewedPublisher ...
Brown, Gordon D, Hardison, Sarah E, Plato, Anthony   +2 more
core   +2 more sources