Results 81 to 90 of about 17,655,159 (178)

Untersuchungen zur Rolle des Thrombozytenrezeptors CLEC-2 (C- type lectin-like receptor 2) in Thrombosemodellen

open access: yes, 2023
Platelets have a key physiological role in haemostasis however, inappropriate thrombus formation can lead to cardiovascular diseases such as myocardial infarction or stroke.
Brown, Helena Charlotte
core   +1 more source

Nanobiocatalysts: Potential Applications in Biofuel Production and Biotransformation

open access: yesCarbon Neutralization, Volume 5, Issue 3, May 2026.
The application of nanobiocatalysts in the field of biofuel production and the biotransformation of substrate were reviewed. Further, the possible research gaps in the field of biofuel and value‐added compound production and a possible way to enhance the application of nanobiocatalyst in future development are highlighted.
Preethi Muthu   +4 more
wiley   +1 more source

Level of podoplanin expression in HeLa cells and the purity of the Fc-CLEC-2 fusion protein.

open access: yes, 2019
(A) Western blot analysis of podoplanin expression levels in pod-HeLa cells, parental HeLa cells, and TE11 cells. Triton X-100-soluble fractions from the indicated cells (4 μg or 20 μg) were analyzed by western blot for podoplanin expression levels.
Yusuke Suzuki (525707)   +10 more
core   +1 more source

Characterisation of platelet receptor CLEC-2 in thrombosis and inflammation [PDF]

open access: yes, 2022
Platelets have an established role in thrombosis and haemostasis. C-type lectin-like receptor 2 (CLEC-2) is highly expressed on platelets and a subpopulation of myeloid cells, and is critical in lymphatic development.
Bourne, Joshua Henry
core  

Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.

open access: yesPLoS Computational Biology, 2022
The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) domain ...
Zahra Maqsood   +18 more
doaj   +1 more source

Lactiplantibacillus plantarum CQPC03 Reduces Carrageenan‐Induced Thrombosis in Mice via Controlling the Flora in the Gut

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Lactiplantibacillus plantarum CQPC03 could reduce carrageenan‐induced thrombosis in mice. ABSTRACT This investigation reports the effects of Lactiplantibacillus plantarum CQPC03 (LP‐CQPC03) on preventing thrombus formation and reducing intestinal oxidative stress and inflammation in a carrageenan‐induced mouse thrombosis model. High‐throughput 16S rRNA
Xin Zhao   +6 more
wiley   +1 more source

Crystallization and X-ray diffraction analysis of human CLEC-2 [PDF]

open access: yesActa Crystallographica Section F Structural Biology and Crystallization Communications, 2005
The human C-type lectin-like protein CLEC-2 has recently been shown to be expressed on the surface of platelets and to function as a receptor for the snake-venom protein rhodocytin. The C-type lectin-like domain (CTLD) of CLEC-2 was expressed in Escherichia coli, refolded and purified.
Watson, A, O'Callaghan, C
openaire   +2 more sources

Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry

open access: yesPlatelets, 2022
Src tyrosine kinases and spleen tyrosine kinase (Syk) have recently been shown to contribute to sustained platelet aggregation on collagen under arterial shear.
Hilaire Yam Fung Cheung   +5 more
doaj   +1 more source

High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-19

open access: yesPlatelets, 2023
Predicting the clinical course and allocating limited medical resources appropriately is crucial during the COVID-19 pandemic. Platelets are involved in microthrombosis, a critical pathogenesis of COVID-19; however, the role of soluble CLEC-2 (sCLEC-2 ...
Saori Oishi   +9 more
doaj   +1 more source

TGFβ‐Mediated Overexpression of Podoplanin Serves as a Potential Diagnostic Biomarker in Acute Promyelocytic Leukemia

open access: yesMolecular Carcinogenesis, Volume 65, Issue 5, Page 556-564, May 2026.
ABSTRACT Early diagnosis of acute promyelocytic leukemia (APL), driven by PML‐RARA oncoprotein, is vital for survival, as delays can cause fatal coagulopathy without prompt therapeutic intervention of all‐trans retinoic acid and arsenic trioxide. Although APL is diagnosed using microscopy, immunophenotyping, and FISH/PCR for PML‐RARA, morphological ...
Akash Maity   +17 more
wiley   +1 more source

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