Results 81 to 90 of about 24,575,655 (169)
PLoS Computational Biology, 2022 The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) domain ...
Zahra Maqsood +18 more
doaj +1 more source
, 2009 CLEC-1 und CLEC-2 gehören zu einer Familie von C-Typ lektinähnlichen Rezeptoren mit wichtigen Funktionen im natürlichen Immunsystem wie etwa als Muster-erkennungsrezeptoren auf monozytischen oder dendritischen Zellen.
Sattler, Susanne
core
High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-19
Platelets, 2023 Predicting the clinical course and allocating limited medical resources appropriately is crucial during the COVID-19 pandemic. Platelets are involved in microthrombosis, a critical pathogenesis of COVID-19; however, the role of soluble CLEC-2 (sCLEC-2 ...
Saori Oishi +9 more
doaj +1 more source
Lymphatic Endothelial Cells in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang +5 more
wiley +1 more source
Blood, 2012 Abstract C-type lectin-like receptor 2 (CLEC-2) is an essential platelet-activating receptor in hemostasis and thrombosis that is activated by the snake venom rhodocytin. We present here a differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation ...
Andrés F, Parguiña +9 more
openaire +5 more sources
Synthetic Ligands of Myeloid C‐Type Lectin Receptors
ChemBioChem, Volume 27, Issue 13, 14 July 2026.Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley +1 more source
CLEC-2 suppresses calcification in cultured osteoblasts [PDF]
, 2019 Abstract Podoplanin is the only counter-receptor of platelet CLEC-2 and is expressing on mature osteoblast, but there is no report on the role of podoplanin and CLEC-2 in calcification. This study aimed to investigate the role of podoplanin binding to CLEC-2 in the calcification of osteoblasts carrying homozygously ...
Kanai, Takenori +7 more
openaire +1 more source
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, Volume 293, Issue 13, Page 3991-4013, July 2026.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
CLEC-2 expression is maintained on activated platelets and on platelet microparticles [PDF]
Blood, 2014 Key PointsCLEC-2 activation induces proteolytic cleavage of GPVI and FcγRIIa but not itself. CLEC-2 but not GPVI is detected on platelet-derived microparticles.
Eelo, Gitz +12 more
openaire +2 more sources
Platelets, 2018 The podoplanin-CLEC-2 axis is critical in mice for prevention of hemorrhage in the cerebral vasculature during mid-gestation. This raises the question as to how platelets are captured by podoplanin on neuroepithelial cells in a high shear environment. In
Stephanie E. Lombard +6 more
doaj +1 more source