Results 61 to 70 of about 17,655,159 (178)
Elevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome
Clinical and Applied Thrombosis/Hemostasis, 2022 Podoplanin (PDPN) promotes platelet aggregation and activation by interacting with C-type lectin-like receptor 2(CLEC-2) on platelets. The interaction between the upregulated PDPN and platelet CLEC-2 stimulates venous thrombosis. PDPN was identified as a
Ying Ji MD +8 more
doaj +1 more source
CLEC-2/PDPN signalling phospho proteomics
, 2019 Fold difference values from TMT proteomics of total protein and phosphopeptides, 5 biological replicates: control vs CLEC-2 stimulated. 15 minutes and 24 hour time points.Relating to Figure 3dAbstractLymph nodes (LNs) work as filtering organs, constantly
Chris Tape (6782324) +2 more
core +1 more source
Chemistry – A European Journal, EarlyView.An Artificial metalloenzyme was designed by a Michael addition between a MnSalen complex and a cysteine residue within NikA crystals. The heterogeneous catalyst was found capable of an enantioselective and stereospecific epoxidation of cis‐β‐methylstyrene in cristallo.
Manel Boukhallat +8 more
wiley +1 more source
, 2019 Podoplanin and Fc-CLEC-2 were allowed to form complexes in solution with or without a test compound, and the protein complex was then captured by protein A-beads.
Yusuke Suzuki (525707) +10 more
core +1 more source
Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases
Platelets, 2021 Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi +4 more
doaj +1 more source
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
, 2019 (A and C) Slot blot detection of podoplanin-Fc-CLEC-2 complex formation. Acid-elution fractions were obtained from complexes formed with the indicated concentrations of Fc-CLEC-2 and pod-HeLa lysates, as in Fig 3.
Yusuke Suzuki (525707) +10 more
core +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]
Blood, 2012 AbstractThe C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation, and perinatal lethality.
Finney, Brenda A +15 more
openaire +3 more sources
Renal cells activate the platelet receptor CLEC-2 through podoplanin
, 2008 We have recently shown that the C-type lectin-like receptor, CLEC-2, is expressed on platelets and that it mediates powerful platelet aggregation by the snake venom toxin rhodocytin.
Pearce, AC +13 more
core +2 more sources