Results 61 to 70 of about 24,575,655 (169)

Binding of Fc-CLEC-2 to podoplanin in pod-HeLa cell lysates.

, 2019
(A) Effect of prior reduction of Fc-CLEC-2 disulfide bonds with DTT on its binding to podoplanin. Purified Fc-CLEC-2 in PBS was untreated or treated with 10 mM DTT for 5 h at room temperature.
Yusuke Suzuki (525707), Ching-Ping Tseng (14223), Yoshihide Nakagawa (7430009), Masako Kidokoro (7430006), Makiko Tanaka (122843), Sadaki Inokuchi (845922), Nobuo Watanabe (845921), Shigeaki Inoue (741628), Hideo Tsukamoto (620399), Noriaki Hirayama (518010), Pei-Wen Hsieh (536545)   +10 more
core   +1 more source

Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases

Platelets, 2021
Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi, Christopher W. Smith, Phillip L. R. Nicolson, Steve P. Watson, Mark R. Thomas   +4 more
doaj   +1 more source

Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations

Arthritis &Rheumatology, Accepted Article.
Objectives Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes.
Geoffrey Urbanski, Kimberly E. Taylor, Emily Flynn, Armita Norouzi, Catherine Chu, Brittany Davidson, Arnab Ghosh, Joanne Nititham, Ravi K. Patel, Annie W. Poon, Gabriela K. Fragiadakis, Alexis J. Combes, Walter L. Eckalbar, Lindsey A. Criswell, Chun Jimmie Ye, Caroline H. Shiboski   +15 more
wiley   +1 more source

Schematic representation of podoplanin pull-down by Fc-CLEC-2 and protein A beads and subsequent slot blot analysis.

, 2019
Podoplanin and Fc-CLEC-2 were allowed to form complexes in solution with or without a test compound, and the protein complex was then captured by protein A-beads.
Yusuke Suzuki (525707), Ching-Ping Tseng (14223), Yoshihide Nakagawa (7430009), Masako Kidokoro (7430006), Makiko Tanaka (122843), Sadaki Inokuchi (845922), Nobuo Watanabe (845921), Shigeaki Inoue (741628), Hideo Tsukamoto (620399), Noriaki Hirayama (518010), Pei-Wen Hsieh (536545)   +10 more
core   +1 more source

Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice

Haematologica, 2019
Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induces ...
Surasak Wichaiyo, Sian Lax, Samantha J. Montague, Zhi Li, Beata Grygielska, Jeremy A. Pike, Elizabeth J. Haining, Alexander Brill, Steve P. Watson, Julie Rayes   +9 more
doaj   +1 more source

What Contributes to Self‐Efficacy in Speaking Chinese as a Foreign Language: A Social Cognitive Perspective

International Journal of Applied Linguistics, EarlyView.
ABSTRACT Grounded in social cognitive theory, this study investigated how high‐evidence factors jointly contribute to Chinese‐as‐a‐foreign‐language (CFL) speaking self‐efficacy. Data from 236 CFL learners in Beijing revealed a multifaceted pattern of associations.
Peijian Paul Sun, Jiayi Zhang, Yawen Wang, Lawrence Jun Zhang   +3 more
wiley   +1 more source

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]

Blood, 2012
AbstractThe C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation, and perinatal lethality.
Finney, Brenda A, Schweighoffer, Edina, Navarro-Núñez, Leyre, Bénézech, Cecile, Barone, Francesca, Hughes, Craig E, Langan, Stacey A, Lowe, Kate L, Pollitt, Alice Y, Mourao-Sa, Diego, Sheardown, Steve, Nash, Gerard B, Smithers, Nicholas, Reis e Sousa, Caetano, Tybulewicz, Victor L J, Watson, Steve P   +15 more
openaire   +3 more sources

Slot blot analysis of the concentration dependence of podoplanin sedimentation by Fc-CLEC-2 from pod-HeLa cell lysates.

, 2019
(A and C) Slot blot detection of podoplanin-Fc-CLEC-2 complex formation. Acid-elution fractions were obtained from complexes formed with the indicated concentrations of Fc-CLEC-2 and pod-HeLa lysates, as in Fig 3.
Yusuke Suzuki (525707), Ching-Ping Tseng (14223), Yoshihide Nakagawa (7430009), Masako Kidokoro (7430006), Makiko Tanaka (122843), Sadaki Inokuchi (845922), Nobuo Watanabe (845921), Shigeaki Inoue (741628), Hideo Tsukamoto (620399), Noriaki Hirayama (518010), Pei-Wen Hsieh (536545)   +10 more
core   +1 more source

Individual Differences in the Effects of Life Events on Personality Trait Change

Journal of Personality, EarlyView.
ABSTRACT Objective To date, effects of life events on personality trait change have been unsystematic, tenuous, and difficult to replicate. We focus on individual differences in change processes following life events, which have been neglected in previous studies.
Lara Oeltjen, Christian Kandler
wiley   +1 more source

Characterization and visualization of murine coagulation factor VIII-producing cells in vivo

Scientific Reports, 2021
Coagulation factors are produced from hepatocytes, whereas production of coagulation factor VIII (FVIII) from primary tissues and cell species is still controversial.
Morisada Hayakawa, Asuka Sakata, Hiroko Hayakawa, Hikari Matsumoto, Takafumi Hiramoto, Yuji Kashiwakura, Nemekhbayar Baatartsogt, Noriyoshi Fukushima, Yoichi Sakata, Katsue Suzuki-Inoue, Tsukasa Ohmori   +10 more
doaj   +1 more source