Results 41 to 50 of about 24,575,655 (169)

CLEC-2: the inside story. [PDF]

Blood, 2015
Excessive platelet aggregation at sites of atherosclerotic plaque rupture can result in formation of pathological thrombi that reduce or obstruct blood flow to downstream tissues and cause tissue ischemia or infarction.2 Consequently, antiplatelet drugs have been developed for treatment of acute thrombotic events. Platelet activation and aggregation at
Newman DK.
europepmc   +3 more sources

GPVI and CLEC‐2 in hemostasis and vascular integrity [PDF]

Journal of Thrombosis and Haemostasis, 2010
The glycoprotein VI (GPVI)-FcR gamma-chain complex initiates powerful activation of platelets by the subendothelial matrix proteins collagen and laminin through an immunoreceptor tyrosine-based activation motif (ITAM)-regulated signaling pathway. ITAMs are characterized by two YxxL sequences separated by 6-12 amino acids and are found associated with ...
S P, Watson, J M J, Herbert, A Y, Pollitt   +2 more
openaire   +2 more sources

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Pearce, AC, Watson, Steve P, Watson, Steve P., Eble, JA, Pearce, Andrew C., Pearce, A C, Hughes, C E, McGlade, Jane, Eble, Johannes A., Auger, Jocelyn; id_orcid, McGlade, J, Auger, Jocelyn M., Watson, Steve; id_orcid, Eble, J A, Pearce, Andrew C, Auger, J M, Watson, S P, Hughes, Craig, Hughes, C.E, Hughes, Craig E.   +19 more
core   +2 more sources

CLEC-2/podoplanin and thromboinflammation [PDF]

Blood, 2017
In this issue of Blood, Payne et al revealed a novel function of the platelet C–type lectin-like receptor 2 (CLEC-2)/podoplanin interaction in thromboinflammation: podoplanin expression is upregulated in the vessel wall during venous thrombosis. Venous thrombosis is prevented in the absence of CLEC-2.1 The role of platelet CLEC-2 in thromboinflammation
openaire   +2 more sources

CLEC-2 and podoplanin, partners again. [PDF]

Blood, 2016
In this issue of Blood, Tamura et al reveal a novel function for podoplanin on periarteriolar stromal cells in the bone marrow: promoting megakaryocyte growth and proplatelet formation by interaction with C-type lectin-like receptor 2 (CLEC-2).
Fu J, Xia L.
europepmc   +3 more sources

Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.

PLoS ONE, 2015
The platelet receptor CLEC-2 is involved in thrombosis/hemostasis, but its ligand, podoplanin, is expressed only in advanced atherosclerotic lesions. We investigated CLEC-2 ligands in vessel walls.
Osamu Inoue, Kazuya Hokamura, Toshiaki Shirai, Makoto Osada, Nagaharu Tsukiji, Kinta Hatakeyama, Kazuo Umemura, Yujiro Asada, Katsue Suzuki-Inoue, Yukio Ozaki   +9 more
doaj   +1 more source

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +1 more source

C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice

Platelets, 2023
Kappa-carrageenan (KCG), which is used to induce thrombosis in laboratory animals for antithrombotic drug screening, can trigger platelet aggregation. However, the cell-surface receptor and related signaling pathways remain unclear.
Ryohei Yokomori, Toshiaki Shirai, Nagaharu Tsukiji, Saori Oishi, Tomoyuki Sasaki, Katsuhiro Takano, Katsue Suzuki-Inoue   +6 more
doaj   +1 more source

Functional significance of the platelet immune receptors GPVI and CLEC-2. [PDF]

J Clin Invest, 2019
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM ...
Rayes J, Watson SP, Nieswandt B.
europepmc   +4 more sources

Leishmania donovani Attenuates Dendritic Cell Trafficking to Lymph Nodes by Inhibiting C-Type Lectin Receptor 2 Expression via Transforming Growth Factor-β

Microbiology Spectrum, 2023
To initiate an antileishmanial adaptive immune response, dendritic cells (DCs) must carry Leishmania antigens from peripheral tissues to local draining lymph nodes.
Manisha Yadav, Md. Naushad Akhtar, Manish Mishra, Sandeep Kumar, Raj Kumar, Shubham, Anil Nandal, Pradip Sen   +7 more
doaj   +1 more source