Results 31 to 40 of about 17,655,159 (178)

CLEC‐2 is not required for platelet aggregation at arteriolar shear [PDF]

Journal of Thrombosis and Haemostasis, 2010
The C-type lectin receptor CLEC-2 is expressed primarily on the surface of platelets, where it is present as a dimer, and is found at low level on a subpopulation of other hematopoietic cells, including mouse neutrophils [1–4] Clustering of CLEC-2 by the snake venom toxin rhodocytin, specific antibodies or its endogenous ligand, podoplanin, elicits ...
Craig E, Hughes, Leyre, Navarro-Núñez, Brenda A, Finney, Diego, Mourão-Sá, Alice Y, Pollitt, Steve P, Watson   +5 more
openaire   +3 more sources

The Role of CLEC-2 in and Beyond the Vasculature

, 2017
C-type lectin-like receptor 2 (CLEC-2) is a glycoprotein expressed on the surface of platelets that induces platelet activation including aggregation. Binding of the endogenous ligand podoplanin or the exogenous ligand rhodocytin to CLEC-2 induces tyrosine phosphorylation of the hemITAM motif expressed in its cytoplasmic tail.
Julie Rayes, Alexander T. Hardy, Stephanie E. Lombard, Samantha J. Montague, Steve P. Watson, Kate L. Lowe   +5 more
openaire   +2 more sources

A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation

Blood, 2012
Abstract C-type lectin-like receptor 2 (CLEC-2) is an essential platelet-activating receptor in hemostasis and thrombosis that is activated by the snake venom rhodocytin. We present here a differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation ...
Andrés F, Parguiña, Jana, Alonso, Isaac, Rosa, Paula, Vélez, María J, González-López, Esteban, Guitián, Johannes A, Eble, Johannes A, Ebble, María I, Loza, Ángel, García   +9 more
openaire   +6 more sources

CLEC-2 expression is maintained on activated platelets and on platelet microparticles [PDF]

Blood, 2014
Key PointsCLEC-2 activation induces proteolytic cleavage of GPVI and FcγRIIa but not itself. CLEC-2 but not GPVI is detected on platelet-derived microparticles.
Eelo, Gitz, Alice Y, Pollitt, Jerney J, Gitz-Francois, Osama, Alshehri, Jun, Mori, Samantha, Montague, Gerard B, Nash, Michael R, Douglas, Elizabeth E, Gardiner, Robert K, Andrews, Christopher D, Buckley, Paul, Harrison, Steve P, Watson   +12 more
openaire   +3 more sources

Podoplanin and CLEC-2 levels in patients with COVID-19. [PDF]

Res Pract Thromb Haemost, 2023
Podoplanin (PDPN gene) and CLEC-2 are involved in inflammatory hemostasis and have also been related with the pathogenesis of thrombosis. Emerging evidence also suggest that podoplanin can exert protective effects in sepsis and in acute lung injury.
Borba-Junior IT, Lima F, Vitoria Rodrigues Oliveira DS, Peachazepi Moraes CR, Annichino-Bizzacchi JM, Bombassaro B, Palma AC, Maranhao Costa FT, Moretti ML, Mansour E, Velloso LA, Orsi FA, De Paula EV.   +12 more
europepmc   +3 more sources

CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear. [PDF]

Thromb Haemost, 2022
C-type lectin-like receptor 2 (CLEC-2) is highly expressed on platelets and a subpopulation of myeloid cells, and is critical in lymphatic development.
Bourne JH, Smith CW, Jooss NJ, Di Y, Brown HC, Montague SJ, Thomas MR, Poulter NS, Rayes J, Watson SP.   +9 more
europepmc   +2 more sources

Platelet CLEC-2: a molecule with 2 faces. [PDF]

Blood, 2017
In this issue of Blood , Haining et al reveal an unexpected role for platelet C-type lectin-like receptor-2 (CLEC-2) in thrombosis, which is independent of its hemi-immunoreceptor tyrosine-based activation motif (hemITAM) signaling ...
Xia L.
europepmc   +4 more sources

CLEC-2 and CD177 have a profound effect on the CAF phosphoproteome.

, 2021
(A) Density plots depicting the changes observed in phosphorylated residues (x-axis) versus total protein abundance changes (y-axis), for the 70% protein overlapping proteins between both assays, in all four conditions.
Victoria C. Pham (7388111), Lino C. Gonzalez (11812916), Jillian L. Astarita (11812907), Shilpa Keerthivasan (11812910), Erik Verschueren (753511), Jennie R. Lill (212568), Andrew A. Pierce (4413523), Shannon J. Turley (11812922), Sean M. Peterson (11812913), Nadia Martinez-Martin (11812919), Yasin Şenbabaoğlu (2543956), Bushra Husain (1430635), Sarah Gierke (6560351), Cecile Chalouni (1593517)   +13 more
core   +2 more sources

The Association Between Plasma C-Type Lectin Like Receptors 2 (CLEC-2) and STEMI and its Correlation With Clinicolaboratory Data

Egyptian Journal of Critical Care Medicine, 2023
Objectives To assess the association between plasma C-type lectin-like receptor 2 (CLEC-2) and ST elevation myocardial infarction (STEMI) and its correlation with clinicolaboratory data.
Salwa Hassan Ahmed, Ahmed Abd ElMoez ElSayed, Fatma Abdel Wahab Abdel Maksoud, Lamees Mohamed Fathi, Soliman Belal Soliman   +4 more
doaj   +1 more source

AVALIAÇÃO DA EXPRESSÃO DE PODOPLANINA E CLEC-2 NA DOENÇA FALCIFORME

Hematology, Transfusion and Cell Therapy, 2023
A hipercoagulabilidade é uma característica importante da doença falciforme (DF), e sua fisiopatologia está relacionada à ativação concomitante da hemostasia e da imunidade inata, em um processo conhecido como imunotrombose.
IT Borb-Junior, MS Barbosa, I Santos, BD Benites, FF Costa, EV Paula   +5 more
doaj   +1 more source