Results 51 to 60 of about 17,655,159 (178)

Functional significance of the platelet immune receptors GPVI and CLEC-2. [PDF]

J Clin Invest, 2019
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM ...
Rayes J, Watson SP, Nieswandt B.
europepmc   +4 more sources

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +1 more source

C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice

Platelets, 2023
Kappa-carrageenan (KCG), which is used to induce thrombosis in laboratory animals for antithrombotic drug screening, can trigger platelet aggregation. However, the cell-surface receptor and related signaling pathways remain unclear.
Ryohei Yokomori, Toshiaki Shirai, Nagaharu Tsukiji, Saori Oishi, Tomoyuki Sasaki, Katsuhiro Takano, Katsue Suzuki-Inoue   +6 more
doaj   +1 more source

Leishmania donovani Attenuates Dendritic Cell Trafficking to Lymph Nodes by Inhibiting C-Type Lectin Receptor 2 Expression via Transforming Growth Factor-β

Microbiology Spectrum, 2023
To initiate an antileishmanial adaptive immune response, dendritic cells (DCs) must carry Leishmania antigens from peripheral tissues to local draining lymph nodes.
Manisha Yadav, Md. Naushad Akhtar, Manish Mishra, Sandeep Kumar, Raj Kumar, Shubham, Anil Nandal, Pradip Sen   +7 more
doaj   +1 more source

CLEC-2 is required for development and maintenance of lymph nodes [PDF]

Blood, 2014
Key Points CLEC-2 is necessary for lymphatic cell proliferation and lymph node anlage persistence after birth. Lack of CLEC-2 expression on megakaryocytes and platelets compromises lymph node integrity in adult life.
Cécile, Bénézech, Saba, Nayar, Brenda A, Finney, David R, Withers, Kate, Lowe, Guillaume E, Desanti, Clare L, Marriott, Steve P, Watson, Jorge H, Caamaño, Christopher D, Buckley, Francesca, Barone   +10 more
openaire   +2 more sources

The novel platelet activation receptor CLEC-2

Platelets, 2011
The c-type lectin-like receptor 2 (CLEC-2) was first identified from a bio-informatic screen for c-type lectin-like receptors. However, neither its function nor its ligand(s) had been elucidated for several years. In 2006, we reported that the receptor is expressed on the surface of platelets and serves as a receptor for the snake venom rhodocytin ...
Katsue, Suzuki-Inoue, Osamu, Inoue, Yukio, Ozaki   +2 more
openaire   +2 more sources

Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2

Retrovirology, 2010
Background Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream.
Münch Jan, Schmökel Jan, Kato Yukinari, Glowacka Ilona, Bertram Stephanie, Tsegaye Theodros, Steffen Imke, Chaipan Chawaree, Simmons Graham, Gerardy-Schahn Rita, Pöhlmann Stefan   +10 more
doaj   +1 more source

Slot blot analysis of the effects of hematoporphyrin and 2CP on the binding of Fc-CLEC-2 to podoplanin.

, 2019
(A) Slot blot analysis of the levels of podoplanin and CLEC-2 in the elution fraction from complexes formed in the presence or absence of the indicated concentrations of hematoporphyrin (HPy) or 2CP.
Yusuke Suzuki (525707), Ching-Ping Tseng (14223), Yoshihide Nakagawa (7430009), Masako Kidokoro (7430006), Makiko Tanaka (122843), Sadaki Inokuchi (845922), Nobuo Watanabe (845921), Shigeaki Inoue (741628), Hideo Tsukamoto (620399), Noriaki Hirayama (518010), Pei-Wen Hsieh (536545)   +10 more
core   +1 more source

Binding of Fc-CLEC-2 to podoplanin in pod-HeLa cell lysates.

, 2019
(A) Effect of prior reduction of Fc-CLEC-2 disulfide bonds with DTT on its binding to podoplanin. Purified Fc-CLEC-2 in PBS was untreated or treated with 10 mM DTT for 5 h at room temperature.
Yusuke Suzuki (525707), Ching-Ping Tseng (14223), Yoshihide Nakagawa (7430009), Masako Kidokoro (7430006), Makiko Tanaka (122843), Sadaki Inokuchi (845922), Nobuo Watanabe (845921), Shigeaki Inoue (741628), Hideo Tsukamoto (620399), Noriaki Hirayama (518010), Pei-Wen Hsieh (536545)   +10 more
core   +1 more source

Lymphatic blood filling in CLEC-2-deficient mouse models

, 2020
C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventing ...
Babak J Mehrara (8530731), Kate L Lowe (8530719), Raghu P Kataru (8530725), Yotis A Senis (8530734), Benoît Ho-Tin-Noé (613740), Sian Lax (74987), Julie Rayes (322780), Elizabeth J Haining (8530716), Zoltan Nagy (294624), Bernhard Nieswandt (93831), Dean Pj Kavanagh (8530728), Ying Di (357922), Steve P Watson (6440417), Surasak Wichaiyo (8530722)   +13 more
core   +1 more source