Results 71 to 80 of about 17,655,159 (178)

Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice

Haematologica, 2019
Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induces ...
Surasak Wichaiyo, Sian Lax, Samantha J. Montague, Zhi Li, Beata Grygielska, Jeremy A. Pike, Elizabeth J. Haining, Alexander Brill, Steve P. Watson, Julie Rayes   +9 more
doaj   +1 more source

Individual Differences in the Effects of Life Events on Personality Trait Change

Journal of Personality, EarlyView.
ABSTRACT Objective To date, effects of life events on personality trait change have been unsystematic, tenuous, and difficult to replicate. We focus on individual differences in change processes following life events, which have been neglected in previous studies.
Lara Oeltjen, Christian Kandler
wiley   +1 more source

Characterization and visualization of murine coagulation factor VIII-producing cells in vivo

Scientific Reports, 2021
Coagulation factors are produced from hepatocytes, whereas production of coagulation factor VIII (FVIII) from primary tissues and cell species is still controversial.
Morisada Hayakawa, Asuka Sakata, Hiroko Hayakawa, Hikari Matsumoto, Takafumi Hiramoto, Yuji Kashiwakura, Nemekhbayar Baatartsogt, Noriyoshi Fukushima, Yoichi Sakata, Katsue Suzuki-Inoue, Tsukasa Ohmori   +10 more
doaj   +1 more source

Control of poorly immunogenic tumors with systemic STING agonist‐loaded liposomes targeting cross‐presenting dendritic cells

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
WH‐peptide‐functionalised liposomes encapsulating STING or RIG‐I agonists target intra‐tumoral Clec9A+ cDC1 and pDC, triggering release of type 1 IFN, presentation of CD4 and CD8 endogenous tumor epitopes, expansion of CTL with help from CD4 T cells in spleen, and tumor cell killing.
Bijun Zeng, Meghna Talekar, Thais Aragao‐Horoiwa, Amy Cameron, Guangzu Zhao, Yulia Zybina, Wendy Blumenschein, Karyn van de Mark, Wittaya Suwakulsiri, Gretchen A Baltus, Riccardo Dolcetti, Ranjeny Thomas   +11 more
wiley   +1 more source

C-type lectin-like receptor 2 in platelets amplifies inflammation in rheumatoid arthritis

Research and Practice in Thrombosis and Haemostasis
Background: Platelets play a crucial role not only in thrombosis and hemostasis but also in inflammation, including rheumatoid arthritis. Although synovial cells in the joints express the membrane protein podoplanin, and platelets express the podoplanin ...
Tomoyuki Sasaki, Ewelina Golebiewska, Toshiaki Shirai, Nagaharu Tsukiji, Kensuke Koyama, Shogo Tamura, Shimon Otake, Makoto Osada, Hirotaka Haro, Yukio Ozaki, Katsue Suzuki–Inoue   +10 more
doaj   +1 more source

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

eJHaem, 2021
All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK‐1026.
Bibian M.E. Tullemans, Mieke F.A. Karel, Valentine Léopold, Marieke S. ten Brink, Constance C.F.M.J. Baaten, Sanne L. Maas, Alex F. deVos, Johannes A. Eble, Marten R. Nijziel, Emiel P.C. van derVorst, Judith M.E.M. Cosemans, Johan W.M. Heemskerk, Theodora A.M. Claushuis, Marijke J.E. Kuijpers   +13 more
doaj   +1 more source

Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Autofluorescence in liver tissue is heterogeneous and dynamically altered during metabolic liver disease, complicating spectral flow cytometry analysis. We provide a structured framework for identifying and handling condition‐dependent autofluorescence, demonstrating that inadequate autofluorescence correction biases macrophage quantification and ...
Sabine Daemen, Tuneille I. Adelaar, Panos Barlampas, Xiaodi Zhang, Casper G. Schalkwijk, Kristiaan Wouters   +5 more
wiley   +1 more source

C-type lectin-like receptor 2: roles and drug target

Thrombosis Journal
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocytin, respectively.
Lan Sun, Zhe Wang, Zhiyan Liu, Guangyan Mu, Yimin Cui, Qian Xiang   +5 more
doaj   +1 more source

Investigating the Prospect of C-Type Lectin-like Receptors-2 for Predicting Prognosis of Ischemic Stroke: Rapid Review of Molecular Mechanisms to Clinical Study

Majalah Biomorfologi
Highlights • The potential of CLEC-2 as a prognostic biomarker for ischemic stroke is supported by in vivo and clinical studies demonstrating its role in thrombo-inflammatory mechanisms and clinical outcome prediction.
Rayhan Farandy, Muhammad Ilham Dhiya Rakasiwi, Muhammad Zaki Bariz Amaanullah, Nurul Gusti Khatimah   +3 more
doaj   +1 more source

Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

Platelets, 2021
GPVI and CLEC-2 have emerged as promising targets for long-term prevention of both arterial thrombosis and thrombo-inflammation with a decreased bleeding risk relative to current drugs.
Foteini-Nafsika Damaskinaki, Luis A. Moran, Angel Garcia, Barrie Kellam, Steve P. Watson   +4 more
doaj   +1 more source