Results 71 to 80 of about 24,575,655 (169)

Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey, Annkathrin Ratter, Finn Brigger, Louie Cielen, Pascal Kunz, Ea Tulin, Kinga Mikos, Lothar Dieterich, Marco D'Addio, Cornelia Halin, Richard D. Cummings, Vivianne I. Otto   +11 more
wiley   +1 more source

C-type lectin-like receptor 2: roles and drug target

Thrombosis Journal
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocytin, respectively.
Lan Sun, Zhe Wang, Zhiyan Liu, Guangyan Mu, Yimin Cui, Qian Xiang   +5 more
doaj   +1 more source

C-type lectin-like receptor 2 in platelets amplifies inflammation in rheumatoid arthritis

Research and Practice in Thrombosis and Haemostasis
Background: Platelets play a crucial role not only in thrombosis and hemostasis but also in inflammation, including rheumatoid arthritis. Although synovial cells in the joints express the membrane protein podoplanin, and platelets express the podoplanin ...
Tomoyuki Sasaki, Ewelina Golebiewska, Toshiaki Shirai, Nagaharu Tsukiji, Kensuke Koyama, Shogo Tamura, Shimon Otake, Makoto Osada, Hirotaka Haro, Yukio Ozaki, Katsue Suzuki–Inoue   +10 more
doaj   +1 more source

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

eJHaem, 2021
All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK‐1026.
Bibian M.E. Tullemans, Mieke F.A. Karel, Valentine Léopold, Marieke S. ten Brink, Constance C.F.M.J. Baaten, Sanne L. Maas, Alex F. deVos, Johannes A. Eble, Marten R. Nijziel, Emiel P.C. van derVorst, Judith M.E.M. Cosemans, Johan W.M. Heemskerk, Theodora A.M. Claushuis, Marijke J.E. Kuijpers   +13 more
doaj   +1 more source

Investigating the Prospect of C-Type Lectin-like Receptors-2 for Predicting Prognosis of Ischemic Stroke: Rapid Review of Molecular Mechanisms to Clinical Study

Majalah Biomorfologi
Highlights • The potential of CLEC-2 as a prognostic biomarker for ischemic stroke is supported by in vivo and clinical studies demonstrating its role in thrombo-inflammatory mechanisms and clinical outcome prediction.
Rayhan Farandy, Muhammad Ilham Dhiya Rakasiwi, Muhammad Zaki Bariz Amaanullah, Nurul Gusti Khatimah   +3 more
doaj   +1 more source

Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

Platelets, 2021
GPVI and CLEC-2 have emerged as promising targets for long-term prevention of both arterial thrombosis and thrombo-inflammation with a decreased bleeding risk relative to current drugs.
Foteini-Nafsika Damaskinaki, Luis A. Moran, Angel Garcia, Barrie Kellam, Steve P. Watson   +4 more
doaj   +1 more source

Molecular Mechanisms of Age‐Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics

Aging Cell, Volume 25, Issue 9, September 2026.
Multi‐omics profiling reveals that aging impairs stem/progenitor cell differentiation and taste bud regeneration in the posterior tongue. Age‐related macrophage polarization remodeling, marked by the accumulation of pro‐inflammatory M1 macrophages, contributes to a Thbs1‐enriched inhibitory niche that limits taste cell growth and differentiation ...
Wandong Zhao, Xudong Cha, Yingqi Xie, Enhao Wang, Wenlu Xing, Zengyi Xu, Langchao Liang, Changhai Xiong, Morong Zhou, Penghui Fu, Zhe Wang, Xin Liu, Yiqun Yu, Huanhai Liu, Hanbo Li, Wenwen Ren   +15 more
wiley   +1 more source

Level of podoplanin expression in HeLa cells and the purity of the Fc-CLEC-2 fusion protein.

, 2019
(A) Western blot analysis of podoplanin expression levels in pod-HeLa cells, parental HeLa cells, and TE11 cells. Triton X-100-soluble fractions from the indicated cells (4 μg or 20 μg) were analyzed by western blot for podoplanin expression levels.
Yusuke Suzuki (525707), Ching-Ping Tseng (14223), Yoshihide Nakagawa (7430009), Masako Kidokoro (7430006), Makiko Tanaka (122843), Sadaki Inokuchi (845922), Nobuo Watanabe (845921), Shigeaki Inoue (741628), Hideo Tsukamoto (620399), Noriaki Hirayama (518010), Pei-Wen Hsieh (536545)   +10 more
core   +1 more source

Existential Constructions and Syntactic Complexity in Chinese EFL Writing: A Corpus‐Based Comparative Study With ChatGPT‐Enhanced Analysis

European Journal of Education, Volume 61, Issue 3, September 2026.
ABSTRACT Existential constructions (ECs) play an important role in academic writing by introducing new information, expressing epistemic stance and facilitating information flow. Examining how EFL learners use different EC types can offer valuable insights into their syntactic development and writing proficiency. Previous research, however, has focused
Bingwei li, Lehua Zhang, Yutong Ao, Xiaoyu Xiao   +3 more
wiley   +1 more source

Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry

Platelets, 2022
Src tyrosine kinases and spleen tyrosine kinase (Syk) have recently been shown to contribute to sustained platelet aggregation on collagen under arterial shear.
Hilaire Yam Fung Cheung, Luis A. Moran, Albert Sickmann, Johan W.M. Heemskerk, Ángel Garcia, Steve P. Watson   +5 more
doaj   +1 more source