Results 91 to 100 of about 24,575,655 (169)
Proteolytic remodelling of the extracellular matrix by pericytes
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
The snake venom, rhodocytin, from the Malayan viper, Calloselasma rhodostoma, and the endogenous podoplanin are identified as ligands for the C-type lectin-like receptor 2 (CLEC-2).
Øyvind Bruserud
doaj +1 more source
No Simple Fluke: Schistosomiasis as an Emerging Regulator of Haematopoiesis
ABSTRACT Schistosomiasis, or bilharzia, is a highly prevalent water‐borne helminth infection that accounts for an estimated 1.5–1.7 billion disability‐adjusted life years lost annually. Pathology driven by adult worms and eggs is accompanied by robust immunomodulation in the human host. Protective responses may promote worm elimination, limit bystander
Shinjini Chakraborty
wiley +1 more source
WH‐peptide‐functionalised liposomes encapsulating STING or RIG‐I agonists target intra‐tumoral Clec9A+ cDC1 and pDC, triggering release of type 1 IFN, presentation of CD4 and CD8 endogenous tumor epitopes, expansion of CTL with help from CD4 T cells in spleen, and tumor cell killing.
Bijun Zeng +11 more
wiley +1 more source
Crystallization and X-ray diffraction analysis of human CLEC-2 [PDF]
The human C-type lectin-like protein CLEC-2 has recently been shown to be expressed on the surface of platelets and to function as a receptor for the snake-venom protein rhodocytin. The C-type lectin-like domain (CTLD) of CLEC-2 was expressed in Escherichia coli, refolded and purified.
Watson, A, O'Callaghan, C
openaire +2 more sources
Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver
Autofluorescence in liver tissue is heterogeneous and dynamically altered during metabolic liver disease, complicating spectral flow cytometry analysis. We provide a structured framework for identifying and handling condition‐dependent autofluorescence, demonstrating that inadequate autofluorescence correction biases macrophage quantification and ...
Sabine Daemen +5 more
wiley +1 more source
Nanobiocatalysts: Potential Applications in Biofuel Production and Biotransformation
The application of nanobiocatalysts in the field of biofuel production and the biotransformation of substrate were reviewed. Further, the possible research gaps in the field of biofuel and value‐added compound production and a possible way to enhance the application of nanobiocatalyst in future development are highlighted.
Preethi Muthu +4 more
wiley +1 more source
Lactiplantibacillus plantarum CQPC03 could reduce carrageenan‐induced thrombosis in mice. ABSTRACT This investigation reports the effects of Lactiplantibacillus plantarum CQPC03 (LP‐CQPC03) on preventing thrombus formation and reducing intestinal oxidative stress and inflammation in a carrageenan‐induced mouse thrombosis model. High‐throughput 16S rRNA
Xin Zhao +6 more
wiley +1 more source
Comparison of the GPVI inhibitors losartan and honokiol
Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Marie-Blanche Onselaer +9 more
doaj +1 more source

