Results 91 to 100 of about 24,575,655 (169)

Proteolytic remodelling of the extracellular matrix by pericytes

open access: yesThe FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard   +4 more
wiley   +1 more source

The Snake Venom Rhodocytin from Calloselasma rhodostoma— A Clinically Important Toxin and a Useful Experimental Tool for Studies of C-Type Lectin-like Receptor 2 (CLEC-2)

open access: yesToxins, 2013
The snake venom, rhodocytin, from the Malayan viper, Calloselasma rhodostoma, and the endogenous podoplanin are identified as ligands for the C-type lectin-like receptor 2 (CLEC-2).
Øyvind Bruserud
doaj   +1 more source

No Simple Fluke: Schistosomiasis as an Emerging Regulator of Haematopoiesis

open access: yesParasite Immunology, Volume 48, Issue 7, July 2026.
ABSTRACT Schistosomiasis, or bilharzia, is a highly prevalent water‐borne helminth infection that accounts for an estimated 1.5–1.7 billion disability‐adjusted life years lost annually. Pathology driven by adult worms and eggs is accompanied by robust immunomodulation in the human host. Protective responses may promote worm elimination, limit bystander
Shinjini Chakraborty
wiley   +1 more source

Control of poorly immunogenic tumors with systemic STING agonist‐loaded liposomes targeting cross‐presenting dendritic cells

open access: yesClinical &Translational Immunology, Volume 15, Issue 6, 2026.
WH‐peptide‐functionalised liposomes encapsulating STING or RIG‐I agonists target intra‐tumoral Clec9A+ cDC1 and pDC, triggering release of type 1 IFN, presentation of CD4 and CD8 endogenous tumor epitopes, expansion of CTL with help from CD4 T cells in spleen, and tumor cell killing.
Bijun Zeng   +11 more
wiley   +1 more source

Crystallization and X-ray diffraction analysis of human CLEC-2 [PDF]

open access: yesActa Crystallographica Section F Structural Biology and Crystallization Communications, 2005
The human C-type lectin-like protein CLEC-2 has recently been shown to be expressed on the surface of platelets and to function as a receptor for the snake-venom protein rhodocytin. The C-type lectin-like domain (CTLD) of CLEC-2 was expressed in Escherichia coli, refolded and purified.
Watson, A, O'Callaghan, C
openaire   +2 more sources

Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver

open access: yesEuropean Journal of Immunology, Volume 56, Issue 6, June 2026.
Autofluorescence in liver tissue is heterogeneous and dynamically altered during metabolic liver disease, complicating spectral flow cytometry analysis. We provide a structured framework for identifying and handling condition‐dependent autofluorescence, demonstrating that inadequate autofluorescence correction biases macrophage quantification and ...
Sabine Daemen   +5 more
wiley   +1 more source

Nanobiocatalysts: Potential Applications in Biofuel Production and Biotransformation

open access: yesCarbon Neutralization, Volume 5, Issue 3, May 2026.
The application of nanobiocatalysts in the field of biofuel production and the biotransformation of substrate were reviewed. Further, the possible research gaps in the field of biofuel and value‐added compound production and a possible way to enhance the application of nanobiocatalyst in future development are highlighted.
Preethi Muthu   +4 more
wiley   +1 more source

Pragmatic Clinical Trial of Fostamatinib as Second‐Line Therapy in Adult Patients With Immune Thrombocytopenia and Insufficient Response to Prior Therapy: The Fostamatinib FORTE Trial

open access: yes
eJHaem, Volume 7, Issue 4, August 2026.
Amber Afzal   +8 more
wiley   +1 more source

Lactiplantibacillus plantarum CQPC03 Reduces Carrageenan‐Induced Thrombosis in Mice via Controlling the Flora in the Gut

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Lactiplantibacillus plantarum CQPC03 could reduce carrageenan‐induced thrombosis in mice. ABSTRACT This investigation reports the effects of Lactiplantibacillus plantarum CQPC03 (LP‐CQPC03) on preventing thrombus formation and reducing intestinal oxidative stress and inflammation in a carrageenan‐induced mouse thrombosis model. High‐throughput 16S rRNA
Xin Zhao   +6 more
wiley   +1 more source

Comparison of the GPVI inhibitors losartan and honokiol

open access: yesPlatelets, 2020
Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Marie-Blanche Onselaer   +9 more
doaj   +1 more source

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