Results 101 to 110 of about 24,575,655 (169)

Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

PLoS ONE, 2013
The platelet aggregation-inducing factor Aggrus, also known as podoplanin, is frequently upregulated in several types of tumors and enhances hematogenous metastasis by interacting with and activating the platelet receptor CLEC-2.
Satoshi Takagi, Shigeo Sato, Tomoko Oh-hara, Miho Takami, Sumie Koike, Yuji Mishima, Kiyohiko Hatake, Naoya Fujita   +7 more
doaj   +1 more source

Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion

Cell Reports, 2019
Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs).
Victor G. Martinez, Valeriya Pankova, Lukas Krasny, Tanya Singh, Spyridon Makris, Ian J. White, Agnesska C. Benjamin, Simone Dertschnig, Harry L. Horsnell, Janos Kriston-Vizi, Jemima J. Burden, Paul H. Huang, Christopher J. Tape, Sophie E. Acton   +13 more
doaj   +1 more source

Untersuchungen zur Rolle des Thrombozytenrezeptors CLEC-2 (C- type lectin-like receptor 2) in Thrombosemodellen

, 2023
Platelets have a key physiological role in haemostasis however, inappropriate thrombus formation can lead to cardiovascular diseases such as myocardial infarction or stroke.
Brown, Helena Charlotte
core   +1 more source

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin

Platelets, 2018
Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a
Stacey A. Langan, Leyre Navarro-Núñez, Steve P. Watson, Gerard B. Nash   +3 more
doaj   +1 more source

Ocular Surface Reconstruction with Cultivated Limbal Epithelial Cells in Limbal Stem Cell Deficiency: One-year Follow-up Results

Türk Oftalmoloji Dergisi, 2012
Pur po se: To evaluate the 1-year follow-up results of cultivated limbal epithelial cell (CLEC) transplantation in unilateral limbal stem cell deficiency (LSCD).
İsmet Durak, Özlem Barut Selver, Esra Erdal, İmge Kunter, Zeynep Özbek Söylemezoğlu, Jose Mario Wolosin   +5 more
doaj   +1 more source

Elevation of plasma podoplanin in Kawasaki disease

Journal of Laboratory Medicine
Kawasaki disease (KD) is a systemic vasculitis that results in abnormalities in the coronary arteries. Podoplanin (PDPN) and its receptor C-type lectin-like receptor 2 (CLEC-2) are involved in inflammatory hemostasis and have also been proved to be ...
Xu Ling, Li Wei, Geng Zhimin, Peng Zhaoyang, Sun Anna, Qin Wenjun, Xie Chunhong, Gong Fangqi, Shen Hongqiang   +8 more
doaj   +1 more source

C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37 [PDF]

, 2018
Cell migration is central to evoking a potent immune response. Dendritic cell (DC) migration to lymph nodes is dependent on the interaction of C-type lectin-like receptor 2 (CLEC-2; encoded by the gene Clec1b), expressed by DCs, with podoplanin ...
De Winde, C, Acton, SE
core   +1 more source

C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37

, 2017
Cell migration is central to evoke a potent immune response. Dendritic cell (DC) migration to lymph nodes is dependent on the interaction of C-type lectin-like receptor 2 (CLEC-2) expressed by DCs, with podoplanin expressed by lymph node stromal cells ...
Carl G Figdor, Michael G Tomlinson, Bernhard Nieswandt, Sophie E Acton, Alie van der Schaaf, Alexandra L Matthews, Helen M McGettrick, Erik Jansen, Annemiek B van Spriel, Charlotte M de Winde, Neil D Tomlinson, Johannes A Eble, Sjoerd van Deventer   +12 more
core   +1 more source

Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model. [PDF]

Blood Adv, 2023
Brown HC, Beck S, Navarro S, Di Y, Soriano Jerez EM, Kaczmarzyk J, Thomas SG, Mirakaj V, Watson SP, Nieswandt B, Stegner D.   +10 more
europepmc   +1 more source

Forming Robust and Highly Li‐Ion Conductive Interfaces in High‐Performance Lithium Metal Batteries Using Chloroethylene Carbonate Additive

Advanced Energy & Sustainability Research
Developing high‐rate Li metal batteries (LMBs) is challenging because of dendrite growth and irreversible parasitic reactions of the Li metal. Herein, a robust and highly ion‐conductive solid electrolyte interphase (SEI) layer is designed on a Li metal ...
Hun Kim, Su-Hyun Lee, Nam-Yung Park, Jae-Min Kim, Jang-Yeon Hwang, Yang-Kook Sun   +5 more
doaj   +1 more source