Results 101 to 110 of about 17,655,159 (178)

Antibody-mediated depletion of human CLEC-2 in a novel humanised mouse model

, 2021
Platelet C-type lectin-like receptor 2 (CLEC-2) has been proposed as a potential anti-thrombotic target as genetic or antibody-mediated receptor deficiency prevents occlusive thrombus formation in mice.
Di, Ying, Navarro, Stefano, Brown, Helena C, Jerez, Eva M Soriano, Nieswandt, Bernhard, Stegner, David, Thomas, Steven G.; id_orcid, Mirakaj, Valbona, Watson, Steve P; id_orcid, Beck, Sarah, Kaczmarzyk, Jana   +10 more
core   +1 more source

Comparison of the GPVI inhibitors losartan and honokiol

Platelets, 2020
Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Marie-Blanche Onselaer, Magdolna Nagy, Chiara Pallini, Jeremy A Pike, Gina Perrella, Lourdes Garcia Quintanilla, Johannes A Eble, Natalie S. Poulter, Johan W.M. Heemskerk, Steve P Watson   +9 more
doaj   +1 more source

Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions

Aging Cell, Volume 25, Issue 2, February 2026.
Genetic variation determines whether microbial interactions extend or shorten host lifespan via redox homeostasis. This discovery highlights the critical role of host genetics in shaping microbiota‐driven aging, offering a new framework for precision microbiome interventions tailored to individual needs for promoting longevity.
Xusheng Hao, Rongwei Yuan, Yafei Guo, Guanyu Chen, Yongqing Guo, Limeng Liu, Fei Lu, Yang Bai, Ye Tian   +8 more
wiley   +1 more source

C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37 [PDF]

, 2018
Cell migration is central to evoke a potent immune response. Dendritic cell (DC) migration to lymph nodes is dependent on the interaction of C-type lectin-like receptor 2 (CLEC-2) expressed by DCs with podoplanin expressed by lymph node stromal cells ...
Figdor, Carl G., Matthews, Alexandra L., Jansen, Erik, Van Der Schaaf, Alie, Acton, Sophie E., Mcgettrick, Helen M.; id_orcid, De Winde, Charlotte M., Tomlinson, Michael G.; id_orcid, Eble, Johannes A., Tomlinson, Neil D., Nieswandt, Bernhard, Van Deventer, Sjoerd, Van Spriel, Annemiek B.   +12 more
core   +1 more source

Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

PLoS ONE, 2013
The platelet aggregation-inducing factor Aggrus, also known as podoplanin, is frequently upregulated in several types of tumors and enhances hematogenous metastasis by interacting with and activating the platelet receptor CLEC-2.
Satoshi Takagi, Shigeo Sato, Tomoko Oh-hara, Miho Takami, Sumie Koike, Yuji Mishima, Kiyohiko Hatake, Naoya Fujita   +7 more
doaj   +1 more source

Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion

Cell Reports, 2019
Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs).
Victor G. Martinez, Valeriya Pankova, Lukas Krasny, Tanya Singh, Spyridon Makris, Ian J. White, Agnesska C. Benjamin, Simone Dertschnig, Harry L. Horsnell, Janos Kriston-Vizi, Jemima J. Burden, Paul H. Huang, Christopher J. Tape, Sophie E. Acton   +13 more
doaj   +1 more source

CLEC-1 and CLEC-2

, 2009
CLEC-1 und CLEC-2 gehören zu einer Familie von C-Typ lektinähnlichen Rezeptoren mit wichtigen Funktionen im natürlichen Immunsystem wie etwa als Muster-erkennungsrezeptoren auf monozytischen oder dendritischen Zellen.
Sattler, Susanne
core  

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin

Platelets, 2018
Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a
Stacey A. Langan, Leyre Navarro-Núñez, Steve P. Watson, Gerard B. Nash   +3 more
doaj   +1 more source

Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

The Journal of biological chemistry, 2010
CLEC-2 has been described recently as playing crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis. The snake venom rhodocytin is known as a strong platelet activator, and we have shown that this effect is mediated by CLEC-2 (Suzuki-Inoue, K., Fuller, G. L., García, A., Eble, J. A., Pöhlmann, S., Inoue, O., Gartner, T.
Katsue, Suzuki-Inoue, Osamu, Inoue, Guo, Ding, Satoshi, Nishimura, Kazuya, Hokamura, Koji, Eto, Hirokazu, Kashiwagi, Yoshiaki, Tomiyama, Yutaka, Yatomi, Kazuo, Umemura, Yonchol, Shin, Masanori, Hirashima, Yukio, Ozaki   +12 more
openaire   +2 more sources

C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37

, 2017
Cell migration is central to evoke a potent immune response. Dendritic cell (DC) migration to lymph nodes is dependent on the interaction of C-type lectin-like receptor 2 (CLEC-2) expressed by DCs, with podoplanin expressed by lymph node stromal cells ...
Carl G Figdor, Michael G Tomlinson, Bernhard Nieswandt, Sophie E Acton, Alie van der Schaaf, Alexandra L Matthews, Helen M McGettrick, Erik Jansen, Annemiek B van Spriel, Charlotte M de Winde, Neil D Tomlinson, Johannes A Eble, Sjoerd van Deventer   +12 more
core   +1 more source