Development of ligands for the platelet receptor CLEC-2
, 2022 Platelets are anucleate cells derived from megakaryocytes, which play an important role in the regulation of haemostasis and thrombosis at the injury site; however, they are also involved in other physiological processes such as inflammation, during which they interact with other immune cells including leukocytes.
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CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice
, 2017 Key Points An inactivating point mutation in the hemITAM motif of murine CLEC-2 reproduces the lymphatic defects seen in CLEC-2–deficient mice. CLEC-2 contributes to thrombus stability in vivo independently of hemITAM signaling.
Karen Wolf +8 more
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Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation. [PDF]
Nat Cardiovasc Res, 2022 Stegner D +17 more
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Curcumin-Based Inhibitors of Thrombosis and Cancer Metastasis Promoting Factor CLEC 2 from Traditional Medicinal Species Curcuma longa. [PDF]
Evid Based Complement Alternat Med, 2022 Chandra Manivannan A +16 more
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Syk-dependent Phosphorylation of CLEC-2 [PDF]
Journal of Biological Chemistry, 2011 Sonia Séverin +7 more
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High-throughput screen identifies MAS9 as a novel inhibitor of the C-type lectin receptor-2 (CLEC-2)–podoplanin interaction [PDF]
Background and Purpose The C-type lectin-like receptor-2 (CLEC-2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to a number of (patho)physiological processes, such as lymphangiogenesis, preservation of blood
Eble, Johannes +8 more
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Recombinant CLEC-2 bound to early and advanced atherosclerotic lesions.
, 2015 A) Advanced lesions (fibrofatty plaques) of the human abdominal aorta were stained by (i) human CLEC-2-rabbit Fc2, (ii) rabbit Fc2, (iii) anti-CD68 (clone PGM-1), and iv) anti-smooth muscle actin. Magnified Fig 1A(i) was inserted into (ii).
Toshiaki Shirai (801311) +9 more
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Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ. [PDF]
Blood Adv, 2021 Oishi S +11 more
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Cancellation of the Calcification in Cultured Osteoblasts by CLEC-2
Journal of Hard Tissue Biology, 2021 Kanai, Takenori +2 more
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Role of platelet CLEC‐2 and podoplanin in inflammation and vascular integrity
, 2017 Introduction: The platelet receptor CLEC‐2 is believed to play a key role in many of the newly emerging roles of platelets, such as development and inflammation. The aim of this thesis was to look further into the interaction of CLEC‐2 and podoplanin and
Lombard, Stephanie Eileen
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