Results 131 to 140 of about 17,655,159 (178)

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP.

Blood, 2022
Shao B, Hoover C, Shi H, Kondo Y, Lee RH, Chen J, Shan X, Song J, McDaniel JM, Zhou M, McGee S, Vanhoorelbeke K, Bergmeier W, López JA, George JN, Xia L.   +15 more
europepmc   +1 more source

Platelet CLEC-2 activation leads to GPIb⍺ shedding: Implications for doxorubicin chemotherapy and thrombosis. [PDF]

J Biol Chem
Rousseau Z, Ma W, Long T, Slavkovic S, Qiu X, Lao X, Wu XG, Joshi K, Zhu YA, Zhu G, Thu KL, Ni H.   +11 more
europepmc   +1 more source

Receptor homodimerization significantly prolongs the lifetime of ligand-induced cross-linking of CLEC-2 but not GPVI. [PDF]

Blood Vessel Thromb Hemost
Clark JC, Martin EM, Slater A, Calebiro D, Koszegi Z, Watson SP.   +5 more
europepmc   +1 more source

The role of GPVI and CLEC-2 in platelet activation by miscellaneous ligands

, 2016
Platelets are an essential factor in wound repair and blood clotting, where exposed sub-endothelial extracellular matrix (ECM) proteins induce activation during vascular injury.
Alshehri, Osama Mohammed D
core  

The prognostic significance of CLEC-2-related gene signal in lung adenocarcinoma: A multicenter development and validation cohort. [PDF]

Clin Transl Med, 2020
Zhou C, Lei L, Ji MH, Yang JJ, Xia H.
europepmc   +1 more source

Decreased plasma level of C-type lectin-like receptor 2 (CLEC-2) in patients with breast cancer. [PDF]

Int J Med Sci
Chen CC, Hsuan CF, Yu TH, Hsu CC, Wu CC, Tang WH, Hung WC, Lu YC, Chung FM, Lee YJ, Wei CT.   +10 more
europepmc   +1 more source

The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure. [PDF]

Nat Commun, 2020
Chauhan A, Sheriff L, Hussain MT, Webb GJ, Patten DA, Shepherd EL, Shaw R, Weston CJ, Haldar D, Bourke S, Bhandari R, Watson S, Adams DH, Watson SP, Lalor PF.   +14 more
europepmc   +1 more source

Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice. [PDF]

Blood Adv
Smith CW, Campos J, Brown HC, Jooss NJ, Ivanova VS, Harbi M, Garcia-Quintanilla L, Jossi S, Perez-Toledo M, Rookes K, Brill A, Theodore LN, Owens T, LaStant J, Foulke MC, Mukai S, Francesco M, Storek M, Hicks A, Langrish C, Nunn PA, Cunningham AF, Chauhan A, Thomas MR, Watson SP, Nicolson PLR.   +25 more
europepmc   +1 more source

Novel platelet activation receptor CLEC-2

Japanese Journal of Thrombosis and Hemostasis, 2011
Katsue SUZUKI-INOUE, Osamu INOUE, Yukio OZAKI   +2 more
openaire   +2 more sources

Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin. [PDF]

Hematology Am Soc Hematol Educ Program, 2019
Suzuki-Inoue K.
europepmc   +1 more source