Results 141 to 150 of about 24,575,655 (169)

Molecular control of platelet extravasation into tumors and its impact on tumor growth. [PDF]

Blood Vessel Thromb Hemost
Lee H, Carlos Alcalde W, Gonzalez Delgado R, Ahn JY, Vasquez M, Cho MS, Wong STC, Sood AK, Afshar-Kharghan V.   +8 more
europepmc   +1 more source

MAPK/PMK-1 innate immune signaling protects the nematode Caenorhabditis elegans from increased intestinal colonization in an animal host-pathogen model in space. [PDF]

NPJ Microgravity
Alcantara AV, Indong RA, Yoon KH, Kim BS, Hashizume T, Higashibata A, Higashitani A, Szewczyk NJ, Etheridge T, Deane CS, Ellwood RA, Kim HS, Mitchell RJ, Lee JI.   +13 more
europepmc   +1 more source

De novo whole transcriptome sequencing reveals differentially expressed messenger RNA and MicroRNA in hepatopancreas of <i>Pandalus hypsinotus</i>. [PDF]

Anim Cells Syst (Seoul)
Lee DH, Kim WR, Shin HJ, Kim JM, Park EG, Lee YJ, Jeong HS, Roh HY, Choi YH, Cha IT, Kim HS.   +10 more
europepmc   +1 more source

The physiological and pathophysiological roles of platelet CLEC-2 [PDF]

Thrombosis and Haemostasis, 2013
SummaryCLEC-2 is a C-type lectin receptor which is highly expressed on platelets but also found at low levels on different immune cells. CLEC-2 elicits powerful platelet activation upon engagement by its endogenous ligand, the mucin-type glycoprotein podoplanin.
Leyre Navarro-Nuñez, Gerard B Nash, Steve P. Watson   +2 more
exaly   +4 more sources

Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2EMBRYONIC/NEONATAL LETHALITY OF CLEC-2-DEFICIENT MICE BY BLOOD/LYMPHATIC MISCONNECTIONS AND IMPAIRED THROMBUS FORMATION OF CLEC-2-DEFICIENT PLATELETS*♦

Journal of Biological Chemistry, 2010
CLEC-2 has been described recently as playing crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis. The snake venom rhodocytin is known as a strong platelet activator, and we have shown that this effect is mediated by CLEC-2 (Suzuki-Inoue, K., Fuller, G. L., García, A., Eble, J. A., Pöhlmann, S., Inoue, O., Gartner, T.
Satoshi Nishimura, Katsue Suzuki-Inoue, Yutaka Yatomi   +2 more
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

CLEC-2-Induced Signaling in Blood Platelets

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2018
Platelet activating receptor CLEC-2 has been identified on platelet surface a decade ago. The only confirmed endogenous CLEC-2 agonist is podoplanin. Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, reticular fibroblastic cells in lymph nodes, kidney podocytes and by cells of certain tumors.
A A, Martyanov, V N, Kaneva, M A, Panteleev, A N, Sveshnikova   +3 more
openaire   +2 more sources

Platelet CLEC-2 and podoplanin in cancer metastasis

Thrombosis Research, 2012
It has long been recognised that the function of platelets in health and disease span far beyond their roles in haemostasis and thrombosis. The observation that tumour cells induce platelet aggregation was followed by extensive experimental evidence linking platelets to cancer progression.
Kate L, Lowe, Leyre, Navarro-Nunez, Stephen P, Watson   +2 more
openaire   +2 more sources

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

Blood, 2009
Abstract Damage to the integrity of the vessel wall leads to exposure of the subendothelial extracellular matrix (ECM), triggering platelet activation and aggregation. This process is essential for primary hemostasis but it may also lead to arterial thrombosis. Although the mechanisms underlying platelet activation on the ECM are well
Frauke, May, Ina, Hagedorn, Irina, Pleines, Markus, Bender, Timo, Vögtle, Johannes, Eble, Margitta, Elvers, Bernhard, Nieswandt   +7 more
openaire   +2 more sources

Fucoidan Is a Novel Platelet Agonist for CLEC-2 Receptor

Blood, 2012
Abstract Abstract 94 Fucoidan, a sulphated polysaccharide from fucus vesiculosus, decreases bleeding time and clotting time in hemophilia, possibly through inhibition of tissue factor pathway inhibitor (TFPI) (Prasad et al., Blood 111:672, 2008).
Bhanukanth Manne, Todd M Getz, Craig Hughes, Carol T Dangelmaier, Steve P Watson, Satya P. Kunapuli   +5 more
openaire   +1 more source

CLEC-2

2012
Angharad E. Fenton-May, Christopher A. O’Callaghan   +1 more
openaire   +1 more source