Results 21 to 30 of about 24,575,655 (169)

Platelet CLEC-2: Roles Beyond Hemostasis

Seminars in Thrombosis and Hemostasis, 2017
AbstractC-type lectin-like receptor 2 (CLEC-2) has been identified on the surface of platelets as a receptor for a platelet activating snake venom, rhodocytin/aggretin. CLEC-2 belongs to a C-type lectin superfamily and binds to a sialoglycoprotein, podoplanin, in vivo.
Katsue, Suzuki-Inoue, Nagaharu, Tsukiji, Toshiaki, Shirai, Makoto, Osada, Osamu, Inoue, Yukio, Ozaki   +5 more
openaire   +3 more sources

CLEC-2 activates Syk through dimerization [PDF]

Blood, 2010
AbstractThe C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including phospholipase-C γ2. Signaling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequence in the CLEC-2 cytosolic tail ...
Hughes, C. E., Pollitt, A. Y., Mori, J., Eble, J. A., Tomlinson, Michael G., Hartwig, J. H., O'Callaghan, C. A., Futterer, K., Watson, Steve P   +8 more
openaire   +6 more sources

sCLEC-2 (Soluble C-Type Lectin-like Receptor 2) as a New Diagnostic Marker of Platelet Activation in Colorectal Cancer Patients—A Preliminary Study [PDF]

Diagnostics
Background/Objectives: CLEC-2 (C-type lectin-like receptor 2), the newest discovered platelet receptor, is involved in platelet activation and aggregation, the inflammatory response, tumor growth, metastasis, and angiogenesis.
Violetta Dymicka-Piekarska, Mariusz Gryko, Anna Justyna Milewska, Blanka Wolszczak-Biedrzycka, Maja Aleksandra Oksentowicz, Elżbieta Motybel-Iwańczuk, Paweł Pawlak, Justyna Dorf   +7 more
doaj   +2 more sources

Gut-derived Faecalibaculum rodentium exerts anti-cancer effects on colorectal cancer by modulating PDPN-CLEC-2 signaling pathway [PDF]

mSystems
Dynamic changes in microbial composition are related to the progression of colorectal cancer (CRC); however, specific microbes with anti-CRC properties have not been identified.
Xiaojuan Yang, Miao Liu, Ting Wang, Xinjuan Ma, Zhirong Guan, Bin Ma, Xiangguo Duan, Chunxia Su   +7 more
doaj   +2 more sources

Covalent Insertion of a Mn(Salen) Type Complex in Cross-Linked Protein Crystals: Design of an Enantioselective Artificial Epoxidase. [PDF]

Chemistry
An Artificial metalloenzyme was designed by a Michael addition between a MnSalen complex and a cysteine residue within NikA crystals. The heterogeneous catalyst was found capable of an enantioselective and stereospecific epoxidation of cis‐β‐methylstyrene in cristallo.
Boukhallat M, Benhamed I, Arnone J, Van Baaren S, Rinaldi C, Catty P, Marchi-Delapierre C, Cavazza C, Ménage S.   +8 more
europepmc   +2 more sources

CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION [PDF]

, 2015
Platelets are involved in many processes ranging from fighting microbial infections and triggering inflammation to promoting tumor angiogenesis and metastasis. Nevertheless, the primary physiological function of platelets is to act as essential mediators in maintaining homeostasis of the circulatory system by forming hemostatic thrombi that prevent ...
Manne, Bhanu Kanth
openaire   +2 more sources

GPVI and CLEC-2

, 2019
Glycoprotein (GP) VI and C-type lectin-like receptor 2 (CLEC-2) are important surface receptors expressed on platelets that share a common signaling pathway downstream of a hemi-immunoreceptor tyrosine-based activation motif (hemITAM).
Elizabeth J. Haining, Phillip L.R. Nicolson, Marie-Blanche Onselaer, Natalie S. Poulter, Julie Rayes, Mark R. Thomas, Steve P. Watson   +6 more
openaire   +2 more sources

PDGF upregulates CLEC-2 to induce T regulatory cells. [PDF]

Oncotarget, 2015
The effect of platelet derived growth factor (PDGF) on immune cells is not elucidated. Here, we demonstrate PDGF inhibited the maturation of human DCs and induced IL-10 secretion. Culture of PDGF-DCs with T cells induced the polarization of T cells towards FoxP3 expressing T regulatory cells that secreted IL-10.
Agrawal S, Ganguly S, Hajian P, Cao JN, Agrawal A.   +4 more
europepmc   +8 more sources

The Role of CLEC-2 in and Beyond the Vasculature

, 2017
C-type lectin-like receptor 2 (CLEC-2) is a glycoprotein expressed on the surface of platelets that induces platelet activation including aggregation. Binding of the endogenous ligand podoplanin or the exogenous ligand rhodocytin to CLEC-2 induces tyrosine phosphorylation of the hemITAM motif expressed in its cytoplasmic tail.
Julie Rayes, Alexander T. Hardy, Stephanie E. Lombard, Samantha J. Montague, Steve P. Watson, Kate L. Lowe   +5 more
openaire   +2 more sources

Renal cells activate the platelet receptor CLEC-2 through podoplanin.

, 2008
We have recently shown that the C-type lectin-like receptor, CLEC-2, is expressed on platelets and that it mediates powerful platelet aggregation by the snake venom toxin rhodocytin.
Christou, Charita M, Watson, Steve P, Mistry, Anita R, O'Callaghan, Chris A, Watson, Aleksandra A, Jackson, David G, Johnson, Louise A, Pearce, Andrew C, Pollitt, Alice Y, Fenton-May, Angharad E   +9 more
core   +11 more sources