Results 21 to 30 of about 17,655,159 (178)
Das Hühner CLEC-2 Homolog [PDF]
, 2012 Chicken CLEC-2 homologue: a thrombocyte receptor with activation function The chicken NKC was described to consist of only two C-type lectins, CD69 and a CD94/NKG2 hybrid, both encoded on chromosome 1. This study contributes to the characterisation of the chicken C-type lectin CD94/NKG2 by production of a specific monoclonal mab which was used to ...
Neulen, Marie-Luise
openaire +2 more sources
sCLEC-2 (Soluble C-Type Lectin-like Receptor 2) as a New Diagnostic Marker of Platelet Activation in Colorectal Cancer Patients—A Preliminary Study [PDF]
DiagnosticsBackground/Objectives: CLEC-2 (C-type lectin-like receptor 2), the newest discovered platelet receptor, is involved in platelet activation and aggregation, the inflammatory response, tumor growth, metastasis, and angiogenesis.
Violetta Dymicka-Piekarska +7 more
doaj +2 more sources
Platelet CLEC-2: Roles Beyond Hemostasis
Seminars in Thrombosis and Hemostasis, 2017 AbstractC-type lectin-like receptor 2 (CLEC-2) has been identified on the surface of platelets as a receptor for a platelet activating snake venom, rhodocytin/aggretin. CLEC-2 belongs to a C-type lectin superfamily and binds to a sialoglycoprotein, podoplanin, in vivo.
Katsue, Suzuki-Inoue +5 more
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PDGF upregulates CLEC-2 to induce T regulatory cells. [PDF]
Oncotarget, 2015 The effect of platelet derived growth factor (PDGF) on immune cells is not elucidated. Here, we demonstrate PDGF inhibited the maturation of human DCs and induced IL-10 secretion. Culture of PDGF-DCs with T cells induced the polarization of T cells towards FoxP3 expressing T regulatory cells that secreted IL-10.
Agrawal S +4 more
europepmc +8 more sources
The Platelet Receptor CLEC-2 Is Active as a Dimer
Biochemistry, 2009 The platelet receptor CLEC-2 binds to the snake venom toxin rhodocytin and the tumor cell surface protein podoplanin. Binding of either of these ligands promotes phosphorylation of a single tyrosine residue in the YXXL motif in the intracellular domain of CLEC-2.
Watson, A. +9 more
openaire +4 more sources
Gut-derived Faecalibaculum rodentium exerts anti-cancer effects on colorectal cancer by modulating PDPN-CLEC-2 signaling pathway [PDF]
mSystemsDynamic changes in microbial composition are related to the progression of colorectal cancer (CRC); however, specific microbes with anti-CRC properties have not been identified.
Xiaojuan Yang +7 more
doaj +2 more sources
CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION [PDF]
, 2015 Platelets are involved in many processes ranging from fighting microbial infections and triggering inflammation to promoting tumor angiogenesis and metastasis. Nevertheless, the primary physiological function of platelets is to act as essential mediators in maintaining homeostasis of the circulatory system by forming hemostatic thrombi that prevent ...
Manne, Bhanu Kanth
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Clinical Interpretation of Platelet Activation Marker sCLEC-2 in Antiphospholipid Syndrome. [PDF]
J Clin Lab AnalSoluble C‐type lectin‐like receptor 2 (sCLEC‐2), a marker of platelet activation, was evaluated in patients with antiphospholipid syndrome (APS). Plasma sCLEC‐2 levels and the sCLEC‐2/D‐dimer ratio were significantly elevated in APS compared with other collagen diseases and healthy controls.
Kaneshige R +3 more
europepmc +2 more sources
, 2013 The glycoprotein VI (GPVI)-FcR gamma-chain complex initiates powerful activation of platelets by the subendothelial matrix proteins collagen and laminin, which are exposed following vessel damage.
Alice Y. Pollitt +2 more
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, 2019 Glycoprotein (GP) VI and C-type lectin-like receptor 2 (CLEC-2) are important surface receptors expressed on platelets that share a common signaling pathway downstream of a hemi-immunoreceptor tyrosine-based activation motif (hemITAM).
Elizabeth J. Haining +6 more
openaire +2 more sources