Results 11 to 20 of about 17,655,159 (178)

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis [PDF]

Nature Communications, 2017
Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting ...
Julie Rayes, Siân Lax, Surasak Wichaiyo, Stephanie K. Watson, Ying Di, Stephanie Lombard, Beata Grygielska, Stuart W. Smith, Kassiani Skordilis, Steve P. Watson   +9 more
doaj   +7 more sources

A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction. [PDF]

PLoS ONE, 2019
Podoplanin, a transmembrane glycoprotein, is overexpressed in certain types of tumors and induces platelet aggregation by binding to C-type lectin-like receptor 2 (CLEC-2) on the platelet membrane. Activated platelets release granule components, which in
Nobuo Watanabe, Masako Kidokoro, Yusuke Suzuki, Makiko Tanaka, Shigeaki Inoue, Hideo Tsukamoto, Noriaki Hirayama, Pei-Wen Hsieh, Ching-Ping Tseng, Yoshihide Nakagawa, Sadaki Inokuchi   +10 more
doaj   +3 more sources

The structure of CLEC-2: mechanisms of dimerization and higher-order clustering

Platelets, 2021
The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on hemostasis identifying it as a target for a new class of antiplatelet agent.
Eleyna M Martin, Malou Zuidscherwoude, Luis A Moran   +2 more
exaly   +5 more sources

Roles of the CLEC-2–podoplanin interaction in tumor progression

Platelets, 2018
Podoplanin is a type-I transmembrane sialomucin-like glycoprotein expressed on the surface of several kinds of tumor cells. The podoplanin receptor is a platelet activation receptor known as C-type lectin-like receptor 2 (CLEC-2), which has been ...
Katsue Suzuki-Inoue
doaj   +4 more sources

Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist. [PDF]

Thromb Haemost, 2022
AbstractBackground CLEC-2 is a platelet receptor with an important role in thromboinflammation but a minor role in hemostasis. Two endogenous ligands of CLEC-2 have been identified, the transmembrane protein podoplanin and iron-containing porphyrin hemin, which is formed following hemolysis from red blood cells.
Morán LA, Di Y, Sowa MA, Hermida-Nogueira L, Barrachina MN, Martin E, Clark JC, Mize TH, Eble JA, Moreira D, Pollitt AY, Loza MI, Domínguez E, Watson SP, García Á.   +14 more
europepmc   +5 more sources

Thrombomodulation via CLEC-2 targeting

Current Opinion in Pharmacology, 2009
CLEC-2 is a C-type lectin-like molecule that has recently been identified as a receptor on the surface of platelets. Ligand binding by CLEC-2 promotes phosphorylation of a tyrosine in the cytoplasmic domain YXXL motif of CLEC-2 by Src kinases and further downstream signalling events trigger platelet activation and aggregation.
O'Callaghan, CA, O'Callaghan, Christopher   +1 more
openaire   +4 more sources

Low-dose Btk inhibitors selectively block platelet activation by CLEC-2 [PDF]

Haematologica, 2020
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2 in ...
Phillip L.R. Nicolson, Sophie H. Nock, Joshua Hinds, Lourdes Garcia-Quintanilla, Christopher W. Smith, Joana Campos, Alexander Brill, Jeremy A. Pike, Abdullah O. Khan, Natalie S. Poulter, Diedre M. Kavanagh, Stephanie Watson, Callum N. Watson, Hayley Clifford, Aarnoud P. Huissoon, Alice Y. Pollitt, Johannes A. Eble, Guy Pratt, Steve P. Watson, Craig E. Hughes   +19 more
doaj   +2 more sources

CLEC-2 activates Syk through dimerization [PDF]

Blood, 2010
AbstractThe C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including phospholipase-C γ2. Signaling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequence in the CLEC-2 cytosolic tail ...
Hughes, C. E., Pollitt, A. Y., Mori, J., Eble, J. A., Tomlinson, Michael G., Hartwig, J. H., O'Callaghan, C. A., Futterer, K., Watson, Steve P   +8 more
openaire   +5 more sources

Evaluation of the podoplanin/C-type lectin-like receptor-2 (CLEC-2) pathway as a mediator of platelet and coagulation activation in sickle cell disease [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Sickle cell disease (SCD) is a condition characterized by a prothrombotic state attributed to the simultaneous activation of hemostasis and innate immunity, referred to as thromboinflammation.
Ivanio Teixeira Borba-Junior, Mayck da Silva Barbosa, Carla Roberta Peachazepi Moraes, Letícia Queiroz Silva, Irene Santos, Bruno Benites, Joyce M. Annichino-Bizzacchi, Fernando Ferreira Costa, Erich Vinicius De Paula   +8 more
doaj   +2 more sources

Molecular Analysis of the Interaction of the Snake Venom Rhodocytin with the Platelet Receptor CLEC-2

Toxins, 2011
The Malayan pit viper, Calloselasma rhodostoma, produces a potent venom toxin, rhodocytin (aggretin) which causes platelet aggregation. Rhodocytin is a ligand for the receptor CLEC-2 on the surface of platelets.
Aleksandra A Watson, Christopher A O'Callaghan, Christopher A O’Callaghan   +2 more
exaly   +3 more sources