Results 101 to 110 of about 4,680 (201)

Antitumor Activities by a Humanized Cancer‐Specific Anti‐Podoplanin Monoclonal Antibody humPMab‐117 Against Human Tumors

Cancer Science, Volume 116, Issue 8, Page 2232-2242, August 2025.
A humanized cancer‐specific anti‐podoplanin monoclonal antibody humPMab‐117 exerts antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against human tumor cells. In the xenograft tumor models, humPMab‐117 demonstrated strong antitumor efficacy.
Tomohiro Tanaka, Hiroyuki Suzuki, Tomokazu Ohishi, Manabu Kawada, Mika K. Kaneko, Yukinari Kato   +5 more
wiley   +1 more source

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

Platelets, 2018
The podoplanin-CLEC-2 axis is critical in mice for prevention of hemorrhage in the cerebral vasculature during mid-gestation. This raises the question as to how platelets are captured by podoplanin on neuroepithelial cells in a high shear environment. In
Stephanie E. Lombard, Alice Y. Pollitt, Craig E. Hughes, Ying Di, Tom Mckinnon, Chris A. O’callaghan, Steve P. Watson   +6 more
doaj   +1 more source

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy [PDF]

, 2013
Peer ...
Adams, Ralf H., Alitalo, Kari, Andreas, Martin, Andresen, Volker, Haegerling, Rene, Kiefer, Friedemann, Nurmi, Harri, Pollmann, Cathrin, Schmidt, Christian, Schulte-Merker, Stefan   +9 more
core   +3 more sources

A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation

Blood, 2012
Abstract C-type lectin-like receptor 2 (CLEC-2) is an essential platelet-activating receptor in hemostasis and thrombosis that is activated by the snake venom rhodocytin. We present here a differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation ...
Andrés F, Parguiña, Jana, Alonso, Isaac, Rosa, Paula, Vélez, María J, González-López, Esteban, Guitián, Johannes A, Eble, Johannes A, Ebble, María I, Loza, Ángel, García   +9 more
openaire   +4 more sources

High sensitivity to ocean acidification in wild out‐migrating juvenile Pacific salmon is not impacted by feeding success

Ecological Applications, Volume 35, Issue 5, July 2025.
Abstract Salmon populations are declining worldwide, with high mortality rates during juvenile marine migration presenting a bottleneck to recruitment. The ocean conditions along the main migratory route of juvenile salmon in British Columbia are characterized by high variability in CO2, with the amplitude, duration, and frequency of ocean ...
Andrea Y. Frommel, Arash Akbarzadeh, Virginie Chalifoux, Tobi J. Ming, Brenna Collicutt, Kate Rolheiser, Rumer Opie, Kristina M. Miller, Colin J. Brauner, Brian P. V. Hunt   +9 more
wiley   +1 more source

Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry

Platelets, 2022
Src tyrosine kinases and spleen tyrosine kinase (Syk) have recently been shown to contribute to sustained platelet aggregation on collagen under arterial shear.
Hilaire Yam Fung Cheung, Luis A. Moran, Albert Sickmann, Johan W.M. Heemskerk, Ángel Garcia, Steve P. Watson   +5 more
doaj   +1 more source

CLEC receptors, endocytosis and calcium signaling

AIMS Allergy and Immunology, 2017
Proper immune system function is dependent on precisely evolved sensing and signal transduction events that occur at cellular and subcellular compartment boundaries.
Robert Cote, Laura Lynn Eggink, J. Kenneth Hoober   +2 more
doaj   +1 more source

Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and
Xin Wang, Jie Chen, Hubing Shi
wiley   +1 more source

The Snake Venom Rhodocytin from Calloselasma rhodostoma— A Clinically Important Toxin and a Useful Experimental Tool for Studies of C-Type Lectin-like Receptor 2 (CLEC-2)

Toxins, 2013
The snake venom, rhodocytin, from the Malayan viper, Calloselasma rhodostoma, and the endogenous podoplanin are identified as ligands for the C-type lectin-like receptor 2 (CLEC-2).
Øyvind Bruserud
doaj   +1 more source

Novel platelet activation receptor CLEC‐2: from discovery to prospects [PDF]

Journal of Thrombosis and Haemostasis, 2011
C-type lectin-like receptor 2 (CLEC-2) has been identified as a receptor for the platelet activating snake venom rhodocytin. CLEC-2 elicits powerful platelet activation signals in conjunction with Src, Syk kinases, and phospholipase Cγ2, similar to the collagen receptor glycoprotein (GP) VI/FcRγ-chain complex.
Katsue Suzuki-Inoue, Yukio Ozaki, Osamu Inoue   +2 more
openaire   +2 more sources