Results 101 to 110 of about 4,811 (202)
Blood, 2012 Abstract C-type lectin-like receptor 2 (CLEC-2) is an essential platelet-activating receptor in hemostasis and thrombosis that is activated by the snake venom rhodocytin. We present here a differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation ...
Andrés F, Parguiña +9 more
openaire +4 more sources
High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-19
Platelets, 2023 Predicting the clinical course and allocating limited medical resources appropriately is crucial during the COVID-19 pandemic. Platelets are involved in microthrombosis, a critical pathogenesis of COVID-19; however, the role of soluble CLEC-2 (sCLEC-2 ...
Saori Oishi +9 more
doaj +1 more source
How to perform aggregometry and lumi-aggregometry in mouse platelets [PDF]
, 2018 Light transmission aggregometry (LTA) and lumi-aggregometry are the gold standard platelet assays both clinically and for basic research. The availability of different strains of genetically modified mice, and mouse models of human disease means that ...
Craig E. Hughes +4 more
core +1 more source
Regulation &Governance, Volume 20, Issue 1, Page 226-243, January 2026.ABSTRACT Adopting a broad understanding of compliance as adherence to norms, this study examines the role of the Chinese–Hungarian Bilingual School in Budapest in the propagation of institutional, educational, and civic norms, through an anthropological inquiry into the discourses and practices embraced and enacted by teachers, parents, and students ...
Fanni Beck, Pál Nyíri
wiley +1 more source
Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.We provide the first single‐cell atlas of the human decidua in advanced maternal age (AMA). A novel PRR15‐TGF‐β axis is identified, where PRR15 loss drives stromal fibrosis and decidualisation failure. This study reveals that AMA‐associated uterine fibrosis begins in the first trimester, shifting focus to maternal factors.
Hongliang Xie +13 more
wiley +1 more source
Platelets, 2018 The podoplanin-CLEC-2 axis is critical in mice for prevention of hemorrhage in the cerebral vasculature during mid-gestation. This raises the question as to how platelets are captured by podoplanin on neuroepithelial cells in a high shear environment. In
Stephanie E. Lombard +6 more
doaj +1 more source
Platelet signaling: a complex interplay between inhibitory and activatory networks [PDF]
, 2016 The role of platelets in hemostasis and thrombosis is dependent on a complex balance of activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy vasculature suppress platelet activation in the absence of platelet ...
Bye, Alex P. +2 more
core +1 more source
Evaluation of Antidepressant Effects of Zhuyeqing Liquor Using C. elegans as a Model
Food Science &Nutrition, Volume 13, Issue 12, December 2025.C. elegans model was used to investigate the antidepressant effects and mechanism of ZYQL. Ten biomarkers related to depression were screened and validated in fluoxetine‐treated groups. This research is useful for formulating antidepressant beverages from ZYQL. ABSTRACT Depression is a common psychiatric disorder in contemporary society, which severely
Xiaodong Cui +5 more
wiley +1 more source
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets [PDF]
Journal of Clinical Investigation, 2015 Thrombosis is a common, life-threatening consequence of systemic infection; however, the underlying mechanisms that drive the formation of infection-associated thrombi are poorly understood. Here, using a mouse model of systemic Salmonella Typhimurium infection, we determined that inflammation in tissues triggers thrombosis within vessels via ligation ...
Hitchcock, Jessica R. +22 more
openaire +5 more sources
CLEC receptors, endocytosis and calcium signaling
AIMS Allergy and Immunology, 2017 Proper immune system function is dependent on precisely evolved sensing and signal transduction events that occur at cellular and subcellular compartment boundaries.
Robert Cote +2 more
doaj +1 more source