Extracellular Paracoccidioides brasiliensis phospholipase B involvement in alveolar macrophage interaction [PDF]
, 2010 Background: Phospholipase B (PLB) has been reported to be one of the virulence factors for human pathogenic fungi and has also been described as necessary for the early events in infection.
Andrade, Rosângela Vieira de +5 more
core +4 more sources
Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion
Cell Reports, 2019 Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs).
Victor G. Martinez +13 more
doaj +1 more source
Comparison of the GPVI inhibitors losartan and honokiol
Platelets, 2020 Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Marie-Blanche Onselaer +9 more
doaj +1 more source
Análisis proteómico de la vía de señalización de CLEC-2 en plaquetas humanas mediante 2-D-DIGE y 2-DE combinado con tinción con SyproRubi: comparación de ambas aproximaciones experimentales [PDF]
, 2012 Comunicaciones a ...
García, Ángel +3 more
core
Akt and mitogen-activated protein kinase enhance C-type lectin-like receptor 2-mediated platelet activation by inhibition of glycogen synthase kinase 3α/β [PDF]
, 2015 BACKGROUND: The C‐type lectin‐like receptor 2 (CLEC‐2) and the collagen receptor glycoprotein (GP)VI activate platelets through Src and Syk tyrosine kinases, and phospholipase Cγ2.
Moroi, A. J., Watson, S. P.
core +1 more source
High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]
, 2011 Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed +54 more
core +1 more source
Platelets, 2018 Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a
Stacey A. Langan +3 more
doaj +1 more source
Türk Oftalmoloji Dergisi, 2012 Pur po se: To evaluate the 1-year follow-up results of cultivated limbal epithelial cell (CLEC) transplantation in unilateral limbal stem cell deficiency (LSCD).
İsmet Durak +5 more
doaj +1 more source
Characterisation of platelet receptor CLEC-2 in thrombosis and inflammation [PDF]
, 2022 Platelets have an established role in thrombosis and haemostasis. C-type lectin-like receptor 2 (CLEC-2) is highly expressed on platelets and a subpopulation of myeloid cells, and is critical in lymphatic development.
Bourne, Joshua Henry
core
Crystal structure of rhodocytin, a ligand for the platelet‐activating receptor CLEC‐2 [PDF]
, 2008 Aleksandra A. Watson +2 more
openalex +1 more source