Results 121 to 130 of about 4,811 (202)

The Platelet Receptor CLEC-2 Is Active as a Dimer

Biochemistry, 2009
The platelet receptor CLEC-2 binds to the snake venom toxin rhodocytin and the tumor cell surface protein podoplanin. Binding of either of these ligands promotes phosphorylation of a single tyrosine residue in the YXXL motif in the intracellular domain of CLEC-2.
Watson, A., Christou, C., James, J., Fenton-May, A., Moncayo, G., Mistry, A., Davis, S., Gilbert, R., Chakera, Aron, O'Callaghan, C.   +9 more
openaire   +3 more sources

Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

PLoS ONE, 2013
The platelet aggregation-inducing factor Aggrus, also known as podoplanin, is frequently upregulated in several types of tumors and enhances hematogenous metastasis by interacting with and activating the platelet receptor CLEC-2.
Satoshi Takagi, Shigeo Sato, Tomoko Oh-hara, Miho Takami, Sumie Koike, Yuji Mishima, Kiyohiko Hatake, Naoya Fujita   +7 more
doaj   +1 more source

Análisis proteómico de la vía de señalización de CLEC-2 en plaquetas humanas mediante 2-D-DIGE y 2-DE combinado con tinción con SyproRubi: comparación de ambas aproximaciones experimentales [PDF]

, 2012
Comunicaciones a ...
García, Ángel, López, María G., Parguiña, Andrés F., Rosa, Isaac   +3 more
core  

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed, Bee K. Tan, Botto, Bouyain, Caparros, Carlow, Ceriello, Chaipan, Daniel A. Mitchell, Daniel Zehnder, Devaraj, Elizabeth J. Soilleux, Feinberg, Fernandez-Real, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghanim, Gringhuis, Guo, Harpal S. Randeva, Held, Hendrik Lehnert, Holman, Ip, Krutzik, Lee, Lillegard, Mitchell, Moller-Kristensen, Nauta, Paidassi, Paul Townsend, Permana, Pohlmann, Reading, Rebecca Ilyas, Robert B. Sim, Russell Wallis, Savill, Schilder, Seelen, Soilleux, Strong, Stuart, Turner, Turner, UKPDS, Wallis, Walport, Walport, Weis, Weis, Worthley, Zeyda   +54 more
core   +1 more source

Integrating Single‐Cell Transcriptomics and Machine Learning to Define an ac4C Gene Signature in Lung Adenocarcinoma

Thoracic Cancer, Volume 16, Issue 15, August 2025.
This study combines single‐cell RNA sequencing and bulk transcriptomics to investigate the role of ac4C RNA modification in lung adenocarcinoma. Using 10 machine learning algorithms, an ac4C‐related gene signature (ARGSig) was constructed and validated for prognosis prediction.
Yuan Wang, Wei Su, Guangyao Zhou, Yijie Wang, Chunnuan Wu, Pengpeng Zhang, Lianmin Zhang   +6 more
wiley   +1 more source

Comparison of the GPVI inhibitors losartan and honokiol

Platelets, 2020
Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Marie-Blanche Onselaer, Magdolna Nagy, Chiara Pallini, Jeremy A Pike, Gina Perrella, Lourdes Garcia Quintanilla, Johannes A Eble, Natalie S. Poulter, Johan W.M. Heemskerk, Steve P Watson   +9 more
doaj   +1 more source

Lymphatic endothelium in health and disease [PDF]

, 2018
The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal ...
Detmar, Michael, Jurisic, Giorgia
core  

Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation [PDF]

, 2016
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and stromal cells that provide ectopic hubs for acquired immune responses.
Christopher D. Buckley, David H. Gardner, Francesca Barone, Nathalie Steinthal, Saba Nayar, Sanjiv A. Luther   +5 more
core   +3 more sources

Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion

Cell Reports, 2019
Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs).
Victor G. Martinez, Valeriya Pankova, Lukas Krasny, Tanya Singh, Spyridon Makris, Ian J. White, Agnesska C. Benjamin, Simone Dertschnig, Harry L. Horsnell, Janos Kriston-Vizi, Jemima J. Burden, Paul H. Huang, Christopher J. Tape, Sophie E. Acton   +13 more
doaj   +1 more source

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin

Platelets, 2018
Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a
Stacey A. Langan, Leyre Navarro-Núñez, Steve P. Watson, Gerard B. Nash   +3 more
doaj   +1 more source