TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists [PDF]
TH Open, 2018 Platelet activation is essential for hemostasis. Central to platelet activation are the signals transmitted through surface receptors such as glycoprotein VI, the protease-activated receptors, and C-type lectin-like receptor 2 (CLEC-2).
John C. Kostyak +8 more
doaj +5 more sources
The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis [PDF]
BMC CancerBackground Podoplanin (PDPN) expressed on tumour cells interacts with platelet C-type lectin-like receptor 2 (CLEC-2). This study aimed to investigate the role of the PDPN-platelet CLEC-2 interaction in melanoma pulmonary metastasis.
Minjia Sheng +3 more
doaj +4 more sources
CLEC-2 and podoplanin, partners again. [PDF]
Blood, 2016 In this issue of Blood, Tamura et al reveal a novel function for podoplanin on periarteriolar stromal cells in the bone marrow: promoting megakaryocyte growth and proplatelet formation by interaction with C-type lectin-like receptor 2 (CLEC-2).
Fu J, Xia L.
europepmc +4 more sources
The podoplanin-CLEC-2 axis inhibits inflammation in sepsis [PDF]
Nature Communications, 2017 Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting ...
Julie Rayes +9 more
doaj +5 more sources
PDGF upregulates CLEC-2 to induce T regulatory cells. [PDF]
Oncotarget, 2015 The effect of platelet derived growth factor (PDGF) on immune cells is not elucidated. Here, we demonstrate PDGF inhibited the maturation of human DCs and induced IL-10 secretion. Culture of PDGF-DCs with T cells induced the polarization of T cells towards FoxP3 expressing T regulatory cells that secreted IL-10.
Agrawal S +4 more
europepmc +7 more sources
Molecular Analysis of the Interaction of the Snake Venom Rhodocytin with the Platelet Receptor CLEC-2 [PDF]
Toxins, 2011 The Malayan pit viper, Calloselasma rhodostoma, produces a potent venom toxin, rhodocytin (aggretin) which causes platelet aggregation. Rhodocytin is a ligand for the receptor CLEC-2 on the surface of platelets.
Christopher A. O’Callaghan +1 more
doaj +2 more sources
Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling [PDF]
Journal of Biological Chemistry, 2010 The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM).
Eble, J. A. +7 more
core +4 more sources
Platelets, 2023 Kappa-carrageenan (KCG), which is used to induce thrombosis in laboratory animals for antithrombotic drug screening, can trigger platelet aggregation. However, the cell-surface receptor and related signaling pathways remain unclear.
Ryohei Yokomori +6 more
doaj +2 more sources
Evaluation of the podoplanin/C-type lectin-like receptor-2 (CLEC-2) pathway as a mediator of platelet and coagulation activation in sickle cell disease [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Sickle cell disease (SCD) is a condition characterized by a prothrombotic state attributed to the simultaneous activation of hemostasis and innate immunity, referred to as thromboinflammation.
Ivanio Teixeira Borba-Junior +8 more
doaj +2 more sources
AVALIAÇÃO DA EXPRESSÃO DE PODOPLANINA E CLEC-2 NA DOENÇA FALCIFORME
Hematology, Transfusion and Cell Therapy, 2023 A hipercoagulabilidade é uma característica importante da doença falciforme (DF), e sua fisiopatologia está relacionada à ativação concomitante da hemostasia e da imunidade inata, em um processo conhecido como imunotrombose.
IT Borb-Junior +5 more
doaj +2 more sources