CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]
Blood, 2011 The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Brenda Finney +15 more
core +8 more sources
CLEC-2 and podoplanin, partners again [PDF]
Blood, 2016 In this issue of Blood, Tamura et al reveal a novel function for podoplanin on periarteriolar stromal cells in the bone marrow: promoting megakaryocyte growth and proplatelet formation by interaction with C-type lectin-like receptor 2 (CLEC-2).
Jianxin Fu, Lijun Xia
europepmc +5 more sources
Gut-derived Faecalibaculum rodentium exerts anti-cancer effects on colorectal cancer by modulating PDPN-CLEC-2 signaling pathway [PDF]
mSystemsDynamic changes in microbial composition are related to the progression of colorectal cancer (CRC); however, specific microbes with anti-CRC properties have not been identified.
Xiaojuan Yang +7 more
doaj +3 more sources
Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2 [PDF]
Platelets, 2021 GPVI and CLEC-2 have emerged as promising targets for long-term prevention of both arterial thrombosis and thrombo-inflammation with a decreased bleeding risk relative to current drugs.
Foteini-Nafsika Damaskinaki +4 more
doaj +6 more sources
The podoplanin-CLEC-2 axis inhibits inflammation in sepsis [PDF]
Nature Communications, 2017 Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting ...
Julie Rayes +9 more
doaj +6 more sources
CLEC-2/podoplanin and thromboinflammation [PDF]
Blood, 2017 In this issue of Blood, Payne et al revealed a novel function of the platelet C–type lectin-like receptor 2 (CLEC-2)/podoplanin interaction in thromboinflammation: podoplanin expression is upregulated in the vessel wall during venous thrombosis. Venous thrombosis is prevented in the absence of CLEC-2.1 The role of platelet CLEC-2 in thromboinflammation
Katsue Suzuki‐Inoue
openalex +3 more sources
Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC‐2 [PDF]
, 2008 Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Craig E. Hughes +5 more
openalex +5 more sources
Podoplanin and CLEC-2 levels in patients with COVID-19. [PDF]
Res Pract Thromb Haemost, 2023 Podoplanin (PDPN gene) and CLEC-2 are involved in inflammatory hemostasis and have also been related with the pathogenesis of thrombosis. Emerging evidence also suggest that podoplanin can exert protective effects in sepsis and in acute lung injury.
Borba-Junior IT +12 more
europepmc +3 more sources
CLEC-2 Prevents Accumulation and Retention of Inflammatory Macrophages During Murine Peritonitis [PDF]
Frontiers in Immunology, 2021 Platelets play a key role in the development, progression and resolution of the inflammatory response during sterile inflammation and infection, although the mechanism is not well understood.
Joshua H. Bourne +19 more
doaj +2 more sources
Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2 [PDF]
Journal of Biological Chemistry, 2010 CLEC-2 has been described recently as playing crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis. The snake venom rhodocytin is known as a strong platelet activator, and we have shown that this effect is mediated by CLEC-2 (Suzuki-Inoue, K., Fuller, G. L., García, A., Eble, J. A., Pöhlmann, S., Inoue, O., Gartner, T.
Katsue Suzuki‐Inoue +12 more
openalex +5 more sources