Quantitative single molecule analysis of podoplanin clustering in fibroblastic reticular cells uncovers CD44 function [PDF]
Open Biology, 2023 Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2).
Shu En Lim +4 more
doaj +3 more sources
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]
, 2011 The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Brenda Finney +15 more
openalex +4 more sources
Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice [PDF]
Haematologica, 2019 Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induces ...
Surasak Wichaiyo +9 more
doaj +5 more sources
CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice. [PDF]
Theranostics, 2021 Tang C +10 more
europepmc +2 more sources
Das Hühner CLEC-2 Homolog [PDF]
, 2012 Das Hühner CLEC-2 Homolog: Ein Thrombozytenrezeptor mit aktivierender Funktion Der Natürliche Killer Gen Komplex (NKC) des Huhnes ist auf dem Chromosom 1 lokalisiert und weist zwei C-typ Lektine auf, von denen das eine als Homolog zu CD69 und das andere
Neulen, Marie-Luise
core +2 more sources
A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction. [PDF]
PLoS ONE, 2019 Podoplanin, a transmembrane glycoprotein, is overexpressed in certain types of tumors and induces platelet aggregation by binding to C-type lectin-like receptor 2 (CLEC-2) on the platelet membrane. Activated platelets release granule components, which in
Nobuo Watanabe +10 more
doaj +2 more sources
Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases
Platelets, 2021 Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi +4 more
doaj +3 more sources
Curcumin-Based Inhibitors of Thrombosis and Cancer Metastasis Promoting Factor CLEC 2 from Traditional Medicinal Species Curcuma longa. [PDF]
Evid Based Complement Alternat Med, 2022 Chandra Manivannan A +16 more
europepmc +3 more sources
The prognostic significance of CLEC-2-related gene signal in lung adenocarcinoma: A multicenter development and validation cohort. [PDF]
Clin Transl Med, 2020 Zhou C, Lei L, Ji MH, Yang JJ, Xia H.
europepmc +2 more sources
CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION [PDF]
, 2015 Platelets are involved in many processes ranging from fighting microbial infections and triggering inflammation to promoting tumor angiogenesis and metastasis. Nevertheless, the primary physiological function of platelets is to act as essential mediators
Manne, Bhanu Kanth
core +2 more sources