Results 21 to 30 of about 4,680 (201)
Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist. [PDF]
Thromb Haemost, 2022 AbstractBackground CLEC-2 is a platelet receptor with an important role in thromboinflammation but a minor role in hemostasis. Two endogenous ligands of CLEC-2 have been identified, the transmembrane protein podoplanin and iron-containing porphyrin hemin, which is formed following hemolysis from red blood cells.
Morán LA +14 more
europepmc +3 more sources
TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists [PDF]
TH Open, 2018 Platelet activation is essential for hemostasis. Central to platelet activation are the signals transmitted through surface receptors such as glycoprotein VI, the protease-activated receptors, and C-type lectin-like receptor 2 (CLEC-2).
John C. Kostyak +8 more
doaj +2 more sources
Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice [PDF]
Haematologica, 2019 Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induces ...
Surasak Wichaiyo +9 more
doaj +4 more sources
CLEC-2: the inside story. [PDF]
Blood, 2015 Excessive platelet aggregation at sites of atherosclerotic plaque rupture can result in formation of pathological thrombi that reduce or obstruct blood flow to downstream tissues and cause tissue ischemia or infarction.2 Consequently, antiplatelet drugs have been developed for treatment of acute thrombotic events. Platelet activation and aggregation at
Newman DK.
europepmc +4 more sources
High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-19 [PDF]
Platelets, 2023 Predicting the clinical course and allocating limited medical resources appropriately is crucial during the COVID-19 pandemic. Platelets are involved in microthrombosis, a critical pathogenesis of COVID-19; however, the role of soluble CLEC-2 (sCLEC-2 ...
Saori Oishi +9 more
doaj +2 more sources
CLEC-2 activates Syk through dimerization [PDF]
Blood, 2010 AbstractThe C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including phospholipase-C γ2. Signaling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequence in the CLEC-2 cytosolic tail ...
Craig E. Hughes +8 more
openalex +7 more sources
The structure of CLEC-2: mechanisms of dimerization and higher-order clustering
Platelets, 2021 The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on hemostasis identifying it as a target for a new class of antiplatelet agent.
Eleyna M Martin +5 more
doaj +5 more sources
AVALIAÇÃO DA EXPRESSÃO DE PODOPLANINA E CLEC-2 NA DOENÇA FALCIFORME
Hematology, Transfusion and Cell Therapy, 2023 A hipercoagulabilidade é uma característica importante da doença falciforme (DF), e sua fisiopatologia está relacionada à ativação concomitante da hemostasia e da imunidade inata, em um processo conhecido como imunotrombose.
IT Borb-Junior +5 more
doaj +2 more sources
Quantitative single molecule analysis of podoplanin clustering in fibroblastic reticular cells uncovers CD44 function [PDF]
Open Biology, 2023 Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2).
Shu En Lim +4 more
doaj +3 more sources
The physiological and pathophysiological roles of platelet CLEC-2 [PDF]
Thrombosis and Haemostasis, 2013 SummaryCLEC-2 is a C-type lectin receptor which is highly expressed on platelets but also found at low levels on different immune cells. CLEC-2 elicits powerful platelet activation upon engagement by its endogenous ligand, the mucin-type glycoprotein podoplanin.
Stacey A. Langan +3 more
openalex +4 more sources