Results 151 to 160 of about 209,174 (306)

Click Chemistry-Enabled Parallel Synthesis of N-Acyl Sulfonamides and Their Evaluation as Carbonic Anhydrase Inhibitors. [PDF]

Molecules
Gavrylenko OV, Vashchenko BV, Naumchyk V, Sosunovych BS, Chuk O, Hrabovskyi O, Kuchuk O, Pogribna A, Nikitin SO, Konovets AI, Brovarets VS, Zozulya SA, Radchenko DS, Grygorenko OO, Moroz YS.   +14 more
europepmc   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

An Amino-Yne Click Chemistry Approach for Multi-Responsive Liquid Crystal Elastomer Actuators. [PDF]

Small
Bescós-Ramo S, Turriani M, Parmeggiani C, Piñol M, Oriol L, Martella D.   +5 more
europepmc   +1 more source

A Dual‐Purpose Non‐Canonical Amino Acid for the Expanded Genetic Code: Combining Metal‐Binding and Click Chemistry

Graham J. Day, Andrey V. Zaytsev, Richard C. Brewster, Valery N. Kozhevnikov, Amanda G. Jarvis   +4 more
openalex   +1 more source

Click Chemistry on a Ruthenium Polypyridine Complex. An Efficient and Versatile Synthetic Route for the Synthesis of Photoactive Modular Assemblies

, 2012
Aurélie Baron, Christian Herrero, Annamaria Quaranta, Marie‐France Charlot, Winfried Leibl, Boris Vauzeilles, Ally Aukauloo   +6 more
openalex   +2 more sources

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Azide-Engineered Nanocrystals Enable Direct Grafting of Conjugated Polymers via Click Chemistry. [PDF]

ACS Omega
Jin W, Jung J.
europepmc   +1 more source

Redox-responsive core cross-linked prodrug micelles prepared by click chemistry for pH-triggered doxorubicin delivery

, 2017
Xuan Thang Cao, Cuong Minh Quoc Le, Hai Ha Pham Thi, G-D. Kim, Y-S. Gal, Kwon Taek Lim   +5 more
openalex   +1 more source

Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin

, 2022
Samer S. Daher, Miseon Lee, Xiao Jin, Christiana N. Teijaro, Pamela R. Barnett, Joel S. Freundlich, Rodrigo Andrade   +6 more
openalex   +2 more sources

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source