Results 191 to 200 of about 209,174 (306)

Triazolinediones applications and recent advances in click chemistry

, 2019
Dhanya Syamala, Anaha Viswarajan Indirabai, Sasidharan Maheswari Sandhya, Lakshmi Gopal, Prasanth B. Nair   +4 more
openalex   +2 more sources

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Click Chemistry-Based Bioconjugation of Iron Oxide Nanoparticles. [PDF]

Small
Asad S, Ahl D, Suárez-López YDC, Erdélyi M, Phillipson M, Teleki A.   +5 more
europepmc   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Tuning of dynamic solvation structures via click chemistry for PEO-based solid polymer electrolytes. [PDF]

Sci Rep
Li R, Yang X, Chen Q, Huang B, Zhao S, Zhang P, Lin J, Zhao J.   +7 more
europepmc   +1 more source

Click chemistry enables comprehensive preclinical evaluation of targeted epigenetic therapies

, 2019
Dean Tyler
openalex   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Signature of click chemistry in advanced techniques for cancer therapeutics. [PDF]

RSC Adv
Ragab SS.
europepmc   +1 more source

Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry

, 2012
Montserrat Shelbourne, Tom Brown, Afaf H. El‐Sagheer, Tom Brown, Tom Brown, Tom Brown   +5 more
openalex   +2 more sources

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source